Protein: LETM2
LETM1 domain-containing protein LETM2, mitochondrial (LETM1 and EF-hand domain-containing protein 2) (Leucine zipper-EF-hand-containing transmembrane protein 1-like)

Gene: LETM2
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q2VYF4

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006851 - mitochondrial calcium ion transmembrane transport
GO:0007005 - mitochondrion organization
GO:0022857 - transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

422221

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

461541

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

749924

KINH
Kinesin-1 heavy chain

1

0

High-throughput

0.458

High

318017

TOM70
Mitochondrial import receptor subunit TOM70

1

2

High-throughput

0.445

High

329275

LETM1
Mitochondrial proton/calcium exchanger protein

1

2

High-throughput

0.445

High

1090416

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.445

High

1180758

BCS1
Mitochondrial chaperone BCS1

1

2

High-throughput

0.445

High

360001

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

647442

SCP2
Sterol carrier protein 2

1

0

High-throughput

0.426

High

690496

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.426

High

751324

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.426

High

1180741

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.426

High

1180746

DDX1
ATP-dependent RNA helicase DDX1

1

0

High-throughput

0.426

High

1180748

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.426

High

1180759

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.426

High

258138

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.407

High

260038

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.407

High

283103

PSIP1
PC4 and SFRS1-interacting protein

1

1

High-throughput

0.407

High

674187

BRD2
Bromodomain-containing protein 2

1

3

High-throughput

0.407

High

717492

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.407

High

903384

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

High-throughput

0.407

High

1009841

NUCB2
Nucleobindin-2

1

1

High-throughput

0.407

High

1038976

NUCB1
Nucleobindin-1

1

1

High-throughput

0.407

High

1141148

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.407

High

1142288

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.407

High

1157517

PKN2
Serine/threonine-protein kinase N2

1

2

High-throughput

0.407

High

1164106

CP51A
Lanosterol 14-alpha demethylase

1

1

High-throughput

0.407

High

1180733

AMOT
Angiomotin

1

2

High-throughput

0.407

High

1180735

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1180736

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.407

High

1180737

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.407

High

1180738

TMTC3
Protein O-mannosyl-transferase TMTC3

1

2

High-throughput

0.407

High

1180739

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.407

High

1180742

SMRC2
SWI/SNF complex subunit SMARCC2

1

2

High-throughput

0.407

High

1180747

SMRC1
SWI/SNF complex subunit SMARCC1

1

1

High-throughput

0.407

High

1180749

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.407

High

1180750

VAT1
Synaptic vesicle membrane protein VAT-1 homolog

1

2

High-throughput

0.407

High

1180751

MPP8
M-phase phosphoprotein 8

1

1

High-throughput

0.407

High

1180752

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.407

High

1180760

WBP11
WW domain-binding protein 11

1

1

High-throughput

0.407

High

1180763

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.407

High

156279

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.279

Low

1180743

DYT2B
Dynein light chain Tctex-type protein 2B

1

0

High-throughput

0.279

Low

1180757

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

81714

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

0

High-throughput

0.232

Low

162351

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.232

Low

295824

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.232

Low

297210

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.232

Low

323729

AP2A2
AP-2 complex subunit alpha-2

1

0

High-throughput

0.232

Low

354710

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.232

Low

458694

SAP
Prosaposin

1

0

High-throughput

0.232

Low

571448

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.232

Low

596657

NCPR
NADPH--cytochrome P450 reductase

1

0

High-throughput

0.232

Low

750426

CSTF2
Cleavage stimulation factor subunit 2

1

0

High-throughput

0.232

Low

873395

LSS
Lanosterol synthase

1

0

High-throughput

0.232

Low

880566

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.232

Low

895572

SERPH
Serpin H1

1

0

High-throughput

0.232

Low

898477

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.232

Low

925722

SC24C
Protein transport protein Sec24C

1

0

High-throughput

0.232

Low

948433

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.232

Low

1058845

ZO1
Tight junction protein 1

1

0

High-throughput

0.232

Low

1068221

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.232

Low

1090342

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.232

Low

1108788

ASAH1
Acid ceramidase

1

0

High-throughput

0.232

Low

1118047

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.232

Low

1120447

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.232

Low

1132735

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.232

Low

1150727

SF01
Splicing factor 1

1

0

High-throughput

0.232

Low

1180734

FA98B
Protein FAM98B

1

0

High-throughput

0.232

Low

1180740

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.232

Low

1180744

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.232

Low

1180745

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.232

Low

1180753

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1180754

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.232

Low

1180755

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low

1180756

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.232

Low

1180761

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.232

Low

1180762

TLN1
Talin-1

1

0

High-throughput

0.232

Low

1180764

MORC2
ATPase MORC2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025