Protein: NKX25
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)

Gene: NKX25, NKX2-5
Organism: Homo sapiens
Interactions: 67
UniProt ID: P52952

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

858120

TBX5
T-box transcription factor TBX5

2

20

Small-scale

0.825

High

174013

SHOX
Short stature homeobox protein

2

18

High-throughput

0.783

High

798815

GATA4
Transcription factor GATA-4

5

14

Small-scale

0.724

High

858122

NKX24
Homeobox protein Nkx-2.4

1

18

High-throughput

0.646

High

858086

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.628

High

211813

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.618

High

858115

FBLI1
Filamin-binding LIM protein 1

2

3

Small-scale

0.606

High

858106

CIP4
Cdc42-interacting protein 4

2

1

High-throughput

0.606

High

858117

RBPMS
RNA-binding protein with multiple splicing

2

4

High-throughput

0.606

High

858094

TLE3
Transducin-like enhancer protein 3

2

20

High-throughput

0.594

High

858101

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.561

High

858116

JARD2
Protein Jumonji

1

20

Small-scale

0.561

High

858110

KRA81
Keratin-associated protein 8-1

2

2

High-throughput

0.553

High

183088

KDM6A
Lysine-specific demethylase 6A

1

5

Small-scale

0.552

High

858093

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.541

High

126449

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

401681

JUN
Transcription factor Jun

1

11

High-throughput

0.536

High

858081

FOXA1
Hepatocyte nuclear factor 3-alpha

1

20

High-throughput

0.536

High

858091

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

858096

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

858100

SMAD4
Mothers against decapentaplegic homolog 4

1

11

High-throughput

0.536

High

858114

IASPP
RelA-associated inhibitor

1

11

High-throughput

0.536

High

858113

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

451223

TPM1
Tropomyosin alpha-1 chain

1

5

High-throughput

0.500

High

524851

XRCC5
X-ray repair cross-complementing protein 5

1

10

High-throughput

0.500

High

552305

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.500

High

650748

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.500

High

720040

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.500

High

737278

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.500

High

802026

NOP2
Probable 28S rRNA

1

2

High-throughput

0.500

High

838734

EMD
Emerin

1

3

High-throughput

0.500

High

849961

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.500

High

858084

RL37
Large ribosomal subunit protein eL37

1

1

High-throughput

0.500

High

858087

TPM4
Tropomyosin alpha-4 chain

1

5

High-throughput

0.500

High

858088

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.500

High

858095

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

5

High-throughput

0.500

High

858098

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.500

High

858103

LBR
Delta(14)-sterol reductase LBR

1

1

High-throughput

0.500

High

858107

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

1

High-throughput

0.500

High

858108

DREB
Drebrin

1

6

High-throughput

0.500

High

858118

SMG1
Serine/threonine-protein kinase SMG1

1

6

High-throughput

0.500

High

858124

MAGD2
Melanoma-associated antigen D2

1

8

High-throughput

0.500

High

858125

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.500

High

858126

PDIP2
Polymerase delta-interacting protein 2

1

2

High-throughput

0.500

High

302343

CMTA2
Calmodulin-binding transcription activator 2

1

0

Small-scale

0.480

High

282050

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

1

0

High-throughput

0.479

High

858097

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.479

High

858104

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.479

High

858109

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.479

High

780952

ID1
DNA-binding protein inhibitor ID-1

1

2

Small-scale

0.479

High

858082

PAX9
Paired box protein Pax-9

1

19

High-throughput

0.479

High

858083

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

858089

EWS
RNA-binding protein EWS

1

8

High-throughput

0.479

High

858090

ID2
DNA-binding protein inhibitor ID-2

1

2

Small-scale

0.479

High

858092

ID3
DNA-binding protein inhibitor ID-3

1

2

Small-scale

0.479

High

858105

IRF4
Interferon regulatory factor 4

1

4

High-throughput

0.479

High

858112

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

858119

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

858123

ELF5
ETS-related transcription factor Elf-5

1

19

High-throughput

0.479

High

418920

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.457

High

833183

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.457

High

858099

TMED1
Transmembrane emp24 domain-containing protein 1

1

5

High-throughput

0.457

High

858121

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.457

High

858085

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.437

High

134860

IMA3
Importin subunit alpha-3

1

4

High-throughput

0.408

High

858102

FLOT2
Flotillin-2

2

0

High-throughput

0.318

High

858111

DYH10
Dynein axonemal heavy chain 10

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024