Protein: EIF3C
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 93 kDa subunit) (eIF3 p93) (Nuclear transport protein NIP1) (Translation initiation factor eIF3, p93 subunit)

Gene: EIF3C, NIP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 160
UniProt ID: P32497

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm
GO:0005852 - eukaryotic translation initiation factor 3 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738372

EIF3A
Eukaryotic translation initiation factor 3 subunit A

16

5

Small-scale

0.986

High

738355

SUI1
Eukaryotic translation initiation factor eIF-1

12

3

Small-scale

0.982

High

738375

IF5
Eukaryotic translation initiation factor 5

17

3

Small-scale

0.766

High

438401

EIF3B
Eukaryotic translation initiation factor 3 subunit B

14

5

Small-scale

0.761

High

738388

EIF3I
Eukaryotic translation initiation factor 3 subunit I

10

3

Small-scale

0.756

High

738428

EIF3G
Eukaryotic translation initiation factor 3 subunit G

7

3

Small-scale

0.746

High

738432

EIF3J
Eukaryotic translation initiation factor 3 subunit J

6

0

Small-scale

0.699

High

737690

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

4

4

High-throughput

0.694

High

738425

RLI1
Translation initiation factor RLI1

4

1

Small-scale

0.686

High

738367

GBLP
Small ribosomal subunit protein RACK1

4

2

Small-scale

0.681

High

738352

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.665

High

738386

IF2P
Eukaryotic translation initiation factor 5B

4

0

Small-scale

0.661

High

738354

RSSA1
Small ribosomal subunit protein uS2A

3

1

Small-scale

0.646

High

478599

IF2B
Eukaryotic translation initiation factor 2 subunit beta

3

3

Small-scale

0.642

High

738382

CSK2C
Casein kinase II subunit beta'

2

2

High-throughput

0.621

High

738415

BRE5
UBP3-associated protein BRE5

2

2

High-throughput

0.621

High

632067

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

Small-scale

0.618

High

444459

DED1
ATP-dependent RNA helicase DED1

2

1

High-throughput

0.611

High

738358

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.602

High

738448

IF6
Eukaryotic translation initiation factor 6

2

1

High-throughput

0.601

High

738083

MYO4
Myosin-4

2

1

High-throughput

0.588

High

738370

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

3

High-throughput

0.588

High

738363

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.586

High

149652

RS9A
Small ribosomal subunit protein uS4A

2

0

High-throughput

0.585

High

738369

OLA1
Obg-like ATPase 1

2

1

High-throughput

0.571

High

434929

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.569

High

738445

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.563

High

544184

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

721776

XPO1
Exportin-1

1

3

High-throughput

0.536

High

738397

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

738403

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.536

High

738420

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

738450

DUF1
DUB-associated factor 1

1

3

High-throughput

0.536

High

738395

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

7

High-throughput

0.533

High

738434

BRE1
E3 ubiquitin-protein ligase BRE1

2

1

Small-scale

0.533

High

526189

HSP72
Heat shock protein SSA2

2

0

High-throughput

0.528

High

670474

SIS1
Protein SIS1

1

1

High-throughput

0.515

High

678514

TAH1
TPR repeat-containing protein associated with Hsp90

1

1

High-throughput

0.515

High

738412

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.515

High

738444

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

1

High-throughput

0.515

High

738361

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.513

High

738378

PIH1
Protein interacting with Hsp90 1

1

0

High-throughput

0.493

High

738435

TMC1
AN1-type zinc finger protein TMC1

1

0

High-throughput

0.493

High

655417

RS3A2
Small ribosomal subunit protein eS1B

1

1

High-throughput

0.489

High

738368

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.489

High

738374

ARPC1
Actin-related protein 2/3 complex subunit 1

1

4

High-throughput

0.489

High

738427

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.489

High

738416

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

0

High-throughput

0.486

High

738441

HUA2
Protein HUA2

1

0

High-throughput

0.486

High

735603

SMY1
Kinesin-related protein SMY1

1

1

High-throughput

0.481

High

738383

END3
Actin cytoskeleton-regulatory complex protein END3

1

1

High-throughput

0.481

High

364414

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

436353

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

438649

SC160
Protein SCP160

1

1

High-throughput

0.479

High

453915

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.479

High

518240

IF4A
ATP-dependent RNA helicase eIF4A

1

3

Small-scale

0.479

High

579050

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

676897

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.479

High

726848

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

738359

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

738376

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

738410

CDH1
APC/C activator protein CDH1

1

4

Small-scale

0.479

High

738426

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

738399

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.460

High

435848

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441782

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

448673

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.458

High

514522

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

536093

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.458

High

558641

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

632869

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.458

High

674487

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

688980

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

709630

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

738356

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

738377

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

738389

TM108
Protein TMA108

1

0

High-throughput

0.458

High

738392

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

738401

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

738413

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

738421

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

738438

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

738442

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

738443

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

585882

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.457

High

392424

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

623802

MYO2
Myosin-2

1

1

High-throughput

0.445

High

738357

PRS7
26S proteasome regulatory subunit 7 homolog

1

3

High-throughput

0.445

High

738387

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

738362

CASP
Protein CASP

1

1

High-throughput

0.439

High

419387

H2A1
Histone H2A.1

1

1

High-throughput

0.437

High

419655

H2A2
Histone H2A.2

1

1

High-throughput

0.437

High

513838

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.437

High

679487

CDC48
Cell division control protein 48

1

2

High-throughput

0.437

High

682208

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

738360

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

738364

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

738366

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.437

High

738405

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.437

High

738414

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

738423

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.437

High

738431

HRQ1
ATP-dependent helicase HRQ1

1

2

Small-scale

0.437

High

738446

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

364981

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

403410

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.426

High

453483

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

592101

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

675819

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

738379

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

738384

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

738393

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

738365

LHS1
Heat shock protein 70 homolog LHS1

1

1

High-throughput

0.407

High

738396

ERJ5
ER-localized J domain-containing protein 5

1

1

High-throughput

0.407

High

738398

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

738404

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.407

High

738422

ADA2
SAGA complex subunit ADA2

1

1

High-throughput

0.407

High

706519

TF2B
Transcription initiation factor IIB

3

0

High-throughput

0.335

High

738419

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.324

High

383585

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.318

High

502919

RS22A
Small ribosomal subunit protein uS8A

2

0

High-throughput

0.318

High

689334

RS7A
Small ribosomal subunit protein eS7A

2

0

High-throughput

0.318

High

512888

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.305

High

738408

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

738409

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.279

Low

738440

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.279

Low

738371

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.269

Low

738390

YRB2
Ran-specific GTPase-activating protein 2

1

0

High-throughput

0.269

Low

738407

MLC1
Myosin light chain 1

1

0

High-throughput

0.269

Low

738439

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

738424

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.251

Low

381954

H4
Histone H4

1

0

High-throughput

0.249

Low

410002

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433519

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

454939

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

504103

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512324

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

661481

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

738353

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

738373

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

738380

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

738385

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

738391

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

738394

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

738400

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

738402

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

738417

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

738418

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

738429

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

738433

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

738436

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

738437

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

738447

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.249

Low

738451

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

703794

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

738381

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

738406

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.232

Low

738411

YG1A
Uncharacterized membrane protein YGR016W

1

0

High-throughput

0.232

Low

738430

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

738449

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025