Protein: TCOF
Treacle protein (Treacher Collins syndrome protein)

Gene: TCOF, TCOF1
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q13428

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

882477

ARRB1
Beta-arrestin-1

5

3

Small-scale

0.716

High

732571

ARRB2
Beta-arrestin-2

4

3

Small-scale

0.691

High

1105058

KBTB8
Kelch repeat and BTB domain-containing protein 8

3

10

Small-scale

0.688

High

997689

CSK21
Casein kinase II subunit alpha

3

12

Small-scale

0.674

High

625357

CSK22
Casein kinase II subunit alpha'

3

12

Small-scale

0.667

High

1105092

DEN2D
DENN domain-containing protein 2D

3

1

High-throughput

0.667

High

871926

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

3

High-throughput

0.662

High

140903

NOP56
Nucleolar protein 56

3

4

Small-scale

0.640

High

1105055

CAMKV
CaM kinase-like vesicle-associated protein

4

2

High-throughput

0.636

High

1006378

SRPK2
SRSF protein kinase 2

2

14

High-throughput

0.634

High

262073

NBN
Nibrin

1

1

Small-scale

0.604

High

129052

MEN1
Menin

2

6

High-throughput

0.584

High

259902

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

285261

EED
Polycomb protein EED

2

20

High-throughput

0.584

High

371951

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

588619

RFA2
Replication protein A 32 kDa subunit

2

9

High-throughput

0.584

High

695377

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

9

High-throughput

0.584

High

768112

RFA3
Replication protein A 14 kDa subunit

2

7

High-throughput

0.584

High

979607

H4
Histone H4

2

11

High-throughput

0.584

High

1105013

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

5

High-throughput

0.584

High

1105014

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

11

Small-scale

0.584

High

1105050

SIR6
NAD-dependent protein deacylase sirtuin-6

2

7

Small-scale

0.584

High

1105068

TOPB1
DNA topoisomerase 2-binding protein 1

2

15

Small-scale

0.584

High

1105086

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

16

High-throughput

0.584

High

1105094

ECT2
Protein ECT2

2

12

High-throughput

0.584

High

961171

FGF12
Fibroblast growth factor 12

2

2

Small-scale

0.574

High

1105011

BECN1
Beclin-1

2

2

High-throughput

0.571

High

289992

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

296884

RASF9
Ras association domain-containing protein 9

1

2

High-throughput

0.536

High

542001

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.536

High

563722

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

667827

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.536

High

849161

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.536

High

854034

KI67
Proliferation marker protein Ki-67

1

14

High-throughput

0.536

High

1050984

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.536

High

1052364

RN5A
2-5A-dependent ribonuclease

1

15

High-throughput

0.536

High

1065079

ITK
Tyrosine-protein kinase ITK/TSK

1

15

High-throughput

0.536

High

1105018

RASA2
Ras GTPase-activating protein 2

1

9

High-throughput

0.536

High

1105040

PXK
PX domain-containing protein kinase-like protein

1

6

High-throughput

0.536

High

1105045

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

1105061

WDR48
WD repeat-containing protein 48

1

20

High-throughput

0.536

High

1105080

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

6

High-throughput

0.536

High

1105089

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

5

High-throughput

0.536

High

431117

LA
Lupus La protein

1

6

High-throughput

0.515

High

521338

ARAF
Serine/threonine-protein kinase A-Raf

1

11

High-throughput

0.515

High

830684

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

1056703

FMR1
Fragile X messenger ribonucleoprotein 1

1

14

High-throughput

0.515

High

1105020

SF3A1
Splicing factor 3A subunit 1

1

9

High-throughput

0.515

High

1105024

RHG44
Rho GTPase-activating protein 44

1

8

High-throughput

0.515

High

1105033

OBSCN
Obscurin

1

16

High-throughput

0.515

High

1105057

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.515

High

1105066

NOC3L
Nucleolar complex protein 3 homolog

1

2

High-throughput

0.515

High

1105074

ZN462
Zinc finger protein 462

1

1

High-throughput

0.515

High

1105102

DJC17
DnaJ homolog subfamily C member 17

1

10

High-throughput

0.515

High

474653

VIME
Vimentin

1

20

High-throughput

0.515

High

593749

PECA1
Platelet endothelial cell adhesion molecule

1

16

High-throughput

0.515

High

1105064

NEK7
Serine/threonine-protein kinase Nek7

1

12

High-throughput

0.515

High

1105041

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1105078

SORT
Sortilin

1

0

High-throughput

0.513

High

507927

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.501

High

855611

CRK
Adapter molecule crk

1

20

High-throughput

0.501

High

396049

ESR1
Estrogen receptor

1

20

High-throughput

0.500

High

788914

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

1105048

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

6

High-throughput

0.489

High

1105088

NUAK2
NUAK family SNF1-like kinase 2

1

1

High-throughput

0.489

High

227543

SPOP
Speckle-type POZ protein

1

7

Small-scale

0.481

High

81702

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

3

High-throughput

0.479

High

123379

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

132012

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

14

High-throughput

0.479

High

157327

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

172779

XPO1
Exportin-1

1

7

High-throughput

0.479

High

190897

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

12

High-throughput

0.479

High

194174

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

241595

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

247309

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

9

High-throughput

0.479

High

272141

OBSL1
Obscurin-like protein 1

1

16

High-throughput

0.479

High

286973

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

17

High-throughput

0.479

High

302508

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

Small-scale

0.479

High

315555

RECQ4
ATP-dependent DNA helicase Q4

1

12

High-throughput

0.479

High

324839

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

339975

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

3

Small-scale

0.479

High

346634

TTC4
Tetratricopeptide repeat protein 4

1

12

High-throughput

0.479

High

355516

NSD2
Histone-lysine N-methyltransferase NSD2

1

19

Small-scale

0.479

High

363230

EGFR
Epidermal growth factor receptor

1

16

High-throughput

0.479

High

400780

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.479

High

406144

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

446983

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

462388

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

15

High-throughput

0.479

High

521673

H14
Histone H1.4

1

14

High-throughput

0.479

High

596081

H12
Histone H1.2

1

14

High-throughput

0.479

High

606726

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

629839

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

643821

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

697105

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

728216

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

High-throughput

0.479

High

761993

GRK5
G protein-coupled receptor kinase 5

1

5

High-throughput

0.479

High

772780

MYH9
Myosin-9

1

7

High-throughput

0.479

High

773177

MYH10
Myosin-10

1

7

High-throughput

0.479

High

775839

HNF1B
Hepatocyte nuclear factor 1-beta

1

18

High-throughput

0.479

High

776811

MYH11
Myosin-11

1

7

High-throughput

0.479

High

791364

SYUA
Alpha-synuclein

1

2

Small-scale

0.479

High

799075

BRCA1
Breast cancer type 1 susceptibility protein

1

13

High-throughput

0.479

High

832711

BCL6
B-cell lymphoma 6 protein

1

2

High-throughput

0.479

High

854841

RECQ1
ATP-dependent DNA helicase Q1

1

8

High-throughput

0.479

High

856673

BAG6
Large proline-rich protein BAG6

1

19

High-throughput

0.479

High

862101

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

879055

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

19

High-throughput

0.479

High

886267

ARL4D
ADP-ribosylation factor-like protein 4D

1

9

High-throughput

0.479

High

897791

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

904676

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

946769

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

970451

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

984745

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

995019

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.479

High

995576

ACTC
Actin, alpha cardiac muscle 1

1

13

High-throughput

0.479

High

998285

H31
Histone H3.1

1

20

High-throughput

0.479

High

1004524

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1008710

RED1
Double-stranded RNA-specific editase 1

1

14

High-throughput

0.479

High

1013756

RL24
Large ribosomal subunit protein eL24

1

1

High-throughput

0.479

High

1016832

H33
Histone H3.3

1

20

High-throughput

0.479

High

1024550

VIGLN
Vigilin

1

7

High-throughput

0.479

High

1045249

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1085538

FOXO1
Forkhead box protein O1

1

12

High-throughput

0.479

High

1096673

RFA4
Replication protein A 30 kDa subunit

1

9

High-throughput

0.479

High

1097274

CBX3
Chromobox protein homolog 3

1

12

High-throughput

0.479

High

1105007

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

High-throughput

0.479

High

1105008

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.479

High

1105009

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

High-throughput

0.479

High

1105010

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.479

High

1105012

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1105015

CUL7
Cullin-7

1

8

High-throughput

0.479

High

1105016

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1105017

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1105019

RBBP5
Retinoblastoma-binding protein 5

1

20

High-throughput

0.479

High

1105021

TERF2
Telomeric repeat-binding factor 2

1

5

High-throughput

0.479

High

1105022

TRBP2
RISC-loading complex subunit TARBP2

1

17

High-throughput

0.479

High

1105023

RBBP7
Histone-binding protein RBBP7

1

14

High-throughput

0.479

High

1105026

LARP7
La-related protein 7

1

9

High-throughput

0.479

High

1105028

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

8

High-throughput

0.479

High

1105035

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1105037

IFIX
Pyrin and HIN domain-containing protein 1

1

5

High-throughput

0.479

High

1105042

ZN598
E3 ubiquitin-protein ligase ZNF598

1

12

High-throughput

0.479

High

1105043

NAA40
N-alpha-acetyltransferase 40

1

6

High-throughput

0.479

High

1105044

ZCH18
Zinc finger CCCH domain-containing protein 18

1

14

High-throughput

0.479

High

1105052

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

High-throughput

0.479

High

1105053

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1105054

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1105060

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.479

High

1105062

RIN3
Ras and Rab interactor 3

1

9

High-throughput

0.479

High

1105065

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1105067

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1105069

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1105072

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.479

High

1105076

NEB2
Neurabin-2

1

15

High-throughput

0.479

High

1105079

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.479

High

1105081

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.479

High

1105083

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1105085

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

7

High-throughput

0.479

High

1105087

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1105090

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

1105093

BRD9
Bromodomain-containing protein 9

1

17

High-throughput

0.479

High

1105095

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

1

Small-scale

0.479

High

1105096

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.479

High

1105098

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

14

High-throughput

0.479

High

1105101

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

1105103

NLE1
Notchless protein homolog 1

1

14

High-throughput

0.479

High

1105104

PIHD1
PIH1 domain-containing protein 1

1

4

High-throughput

0.479

High

1105105

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

1

Small-scale

0.479

High

1105106

PI4KB
Phosphatidylinositol 4-kinase beta

1

4

Small-scale

0.479

High

1105108

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1105109

TBK1
Serine/threonine-protein kinase TBK1

1

8

High-throughput

0.479

High

1105113

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

1105114

PRP19
Pre-mRNA-processing factor 19

1

20

High-throughput

0.479

High

1105115

CC14A
Dual specificity protein phosphatase CDC14A

1

4

High-throughput

0.479

High

1105116

FBW1A
F-box/WD repeat-containing protein 1A

1

18

High-throughput

0.479

High

1105117

NOP58
Nucleolar protein 58

1

4

Small-scale

0.479

High

1105119

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.479

High

1105120

DUS10
Dual specificity protein phosphatase 10

1

3

High-throughput

0.479

High

1058766

COGA1

1

4

High-throughput

0.470

High

1105047

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

1

High-throughput

0.470

High

1055308

APLP2
Amyloid beta precursor like protein 2

1

3

High-throughput

0.470

High

134719

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

257842

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

Small-scale

0.458

High

1105029

MIDN
Midnolin

1

0

High-throughput

0.458

High

1105031

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1105073

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1105077

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

1105099

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

48948

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

429833

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

1054104

BTK
Tyrosine-protein kinase BTK

1

15

High-throughput

0.445

High

1105030

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1105036

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1105046

SLX4
Structure-specific endonuclease subunit SLX4

1

17

High-throughput

0.445

High

1105070

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

1105118

SHLB1
Endophilin-B1

1

15

High-throughput

0.445

High

302826

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.437

High

411875

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

427890

ICAM1
Intercellular adhesion molecule 1

1

3

High-throughput

0.437

High

583301

FOLR1
Folate receptor alpha

1

2

High-throughput

0.437

High

642846

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

1105027

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

5

Small-scale

0.437

High

1105034

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

1105039

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1105059

RASF8
Ras association domain-containing protein 8

1

2

High-throughput

0.437

High

1105063

TIP
T-cell immunomodulatory protein

1

2

High-throughput

0.437

High

1105071

IGSF8
Immunoglobulin superfamily member 8

1

12

High-throughput

0.437

High

1105082

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.437

High

1105084

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1105111

XPO7
Exportin-7

1

6

High-throughput

0.437

High

62504

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

1105075

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.407

High

1105097

NCKX3
Sodium/potassium/calcium exchanger 3

1

4

High-throughput

0.407

High

186416

TM9S1
Transmembrane 9 superfamily member 1

1

0

High-throughput

0.282

High

938161

PKNX1
Homeobox protein PKNOX1

1

0

High-throughput

0.282

High

608259

EGLN
Endoglin

1

0

High-throughput

0.279

Low

1105032

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.279

Low

66841

VTM2B
V-set and transmembrane domain-containing protein 2B

1

0

High-throughput

0.269

Low

505096

BNIP5
Protein BNIP5

1

0

High-throughput

0.269

Low

1004260

F193A
Protein FAM193A

1

0

High-throughput

0.269

Low

1105100

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.269

Low

257456

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

378083

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

1105025

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1105038

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1105049

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

1105110

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.249

Low

1105051

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1105056

DIK2A
Divergent protein kinase domain 2A

1

0

Small-scale

0.232

Low

1105091

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low

1105107

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low

1105112

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025