Protein: MIC27
MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A)

Gene: MIC27, APOOL
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q6UXV4

Gene Ontology (top 5):
GO:0001401 - SAM complex
GO:0005576 - extracellular region
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0007007 - inner mitochondrial membrane organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

348577

AIFM1
Apoptosis-inducing factor 1, mitochondrial

4

2

High-throughput

0.694

High

1250115

SFXN1
Sideroflexin-1

3

2

High-throughput

0.640

High

281606

MTX2
Metaxin-2

2

4

High-throughput

0.611

High

1164433

MIC60
MICOS complex subunit MIC60

2

3

High-throughput

0.611

High

1250107

MIC25
MICOS complex subunit MIC25

2

5

High-throughput

0.611

High

1250121

MIC19
MICOS complex subunit MIC19

2

5

High-throughput

0.611

High

1250129

SAM50
Sorting and assembly machinery component 50 homolog

2

1

High-throughput

0.611

High

845055

EAA3
Excitatory amino acid transporter 3

3

2

High-throughput

0.604

High

1250108

MIC26
MICOS complex subunit MIC26

2

3

High-throughput

0.584

High

1197800

S39AC
Zinc transporter ZIP12

2

1

High-throughput

0.574

High

1204921

MTX3
Metaxin-3

1

4

High-throughput

0.536

High

1250110

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.536

High

1250118

S39A9
Zinc transporter ZIP9

1

1

High-throughput

0.536

High

1250128

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

3

High-throughput

0.536

High

1250101

CAR19
Caspase recruitment domain-containing protein 19

1

0

High-throughput

0.513

High

1250123

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.513

High

1250127

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.513

High

183943

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.489

High

1153260

AAAT
Neutral amino acid transporter B(0)

1

2

High-throughput

0.489

High

221602

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.479

High

292155

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

6

High-throughput

0.479

High

296259

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

485873

COX6C
Cytochrome c oxidase subunit 6C

1

1

High-throughput

0.479

High

559994

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

1013407

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.479

High

1108433

MTX1
Metaxin-1

1

4

High-throughput

0.479

High

1220515

MIC13
MICOS complex subunit MIC13

1

1

High-throughput

0.479

High

1250090

MIC27
MICOS complex subunit MIC27

1

3

High-throughput

0.479

High

1250096

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

Small-scale

0.479

High

1250098

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.479

High

1250100

IMP1L
Mitochondrial inner membrane protease subunit 1

1

2

High-throughput

0.479

High

1250102

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

1250103

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

3

High-throughput

0.479

High

1250106

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

1250111

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

7

High-throughput

0.479

High

1250112

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1250119

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.479

High

1250126

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

1250130

MTCH2
Mitochondrial carrier homolog 2

1

7

High-throughput

0.479

High

216723

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

298733

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.458

High

377620

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

577982

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.458

High

869898

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

940612

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

940663

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.458

High

1083647

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.458

High

1092569

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1093472

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.458

High

1250092

MIRO1
Mitochondrial Rho GTPase 1

1

0

High-throughput

0.458

High

1250104

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1250109

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1250116

STAR7
StAR-related lipid transfer protein 7, mitochondrial

1

0

High-throughput

0.458

High

1250117

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1250120

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.458

High

1250131

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

229535

NRDC
Nardilysin

1

1

High-throughput

0.437

High

588972

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695759

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

1226914

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1250099

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.437

High

1250122

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

844938

EAA2
Excitatory amino acid transporter 2

1

2

High-throughput

0.407

High

854544

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.328

High

1250094

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.328

High

848507

MAGA8
Melanoma-associated antigen 8

2

0

High-throughput

0.313

High

1053020

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.279

Low

1177814

CL12B
C-type lectin domain family 12 member B

1

0

High-throughput

0.279

Low

1250093

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.279

Low

1250095

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1250097

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

1250125

BAZ1B
Tyrosine-protein kinase BAZ1B

1

0

High-throughput

0.279

Low

227596

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

293890

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

314956

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

High-throughput

0.249

Low

904854

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

965042

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1163842

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.249

Low

1250091

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1250105

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

1250113

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1250114

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1250124

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

258949

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025