Protein: RIC3
Protein RIC-3 (Resistant to inhibitor of cholinesterase 3)

Gene: RIC3
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q7Z5B4

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0007204 - positive regulation of cytosolic calcium ion concentration
GO:0007271 - synaptic transmission, cholinergic
GO:0033130 - acetylcholine receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

898106

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

4

1

High-throughput

0.691

High

321287

ERLN2
Erlin-2

3

2

High-throughput

0.667

High

1279062

ZNT5
Proton-coupled zinc antiporter SLC30A5

3

2

High-throughput

0.667

High

1239582

TAPT1
Transmembrane anterior posterior transformation protein 1 homolog

3

0

High-throughput

0.638

High

399701

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

3

0

High-throughput

0.622

High

766658

PHB1
Prohibitin 1

3

1

High-throughput

0.609

High

1239504

ZNT6
Zinc transporter 6

3

2

High-throughput

0.609

High

1279076

PHB2
Prohibitin-2

3

1

High-throughput

0.609

High

1279049

STX12
Syntaxin-12

2

1

High-throughput

0.606

High

1279071

LFG3
Protein lifeguard 3

2

1

High-throughput

0.606

High

160294

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.580

High

325559

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

1272366

FA2H
Fatty acid 2-hydroxylase

2

0

High-throughput

0.580

High

1279054

TM86A
Lysoplasmalogenase TMEM86A

2

0

High-throughput

0.580

High

1279070

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.580

High

1279094

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.580

High

1279104

T3JAM
TRAF3-interacting JNK-activating modulator

2

0

High-throughput

0.580

High

1279061

ZNT7
Zinc transporter 7

2

2

High-throughput

0.571

High

189664

STX7
Syntaxin-7

2

1

High-throughput

0.553

High

1091939

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.547

High

1119184

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.518

High

952926

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.513

High

565650

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.479

High

598121

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.479

High

1279044

RIC3
Protein RIC-3

1

0

High-throughput

0.460

High

537417

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

1279075

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1279105

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

0

High-throughput

0.458

High

1023353

AT2C1
Calcium-transporting ATPase type 2C member 1

1

2

High-throughput

0.445

High

1097816

STX5
Syntaxin-5

1

2

High-throughput

0.445

High

1279067

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.445

High

1279084

GHITM
Growth hormone-inducible transmembrane protein

1

1

High-throughput

0.445

High

1279086

AT131
Endoplasmic reticulum transmembrane helix translocase

1

2

High-throughput

0.445

High

133187

QSOX1
Sulfhydryl oxidase 1

1

0

High-throughput

0.426

High

185005

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.426

High

270020

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.426

High

633426

ANPRB
Atrial natriuretic peptide receptor 2

1

0

High-throughput

0.426

High

719967

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.426

High

1194007

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.426

High

1197245

MBRL
Membralin

1

0

High-throughput

0.426

High

1273239

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.426

High

1279045

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.426

High

1279056

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

0

High-throughput

0.426

High

1279058

MACOI
Macoilin

1

0

High-throughput

0.426

High

1279059

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

1279060

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.426

High

1279068

RGP1
RAB6A-GEF complex partner protein 2

1

0

High-throughput

0.426

High

1279079

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.426

High

1279083

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.426

High

1279098

STX18
Syntaxin-18

1

0

High-throughput

0.426

High

1279099

ATX10
Ataxin-10

1

0

High-throughput

0.426

High

1279108

AP1M2
AP-1 complex subunit mu-2

1

0

High-throughput

0.426

High

207836

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

2

High-throughput

0.407

High

215833

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

1

High-throughput

0.407

High

890346

NU153
Nuclear pore complex protein Nup153

1

1

High-throughput

0.407

High

1105210

S39A6
Zinc transporter ZIP6

1

1

High-throughput

0.407

High

1134968

CUL7
Cullin-7

1

2

High-throughput

0.407

High

1202198

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.407

High

1210723

ZMYM1
Zinc finger MYM-type protein 1

1

1

High-throughput

0.407

High

1212575

HECD3
E3 ubiquitin-protein ligase HECTD3

1

2

High-throughput

0.407

High

1279052

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.407

High

1279057

WDTC1
WD and tetratricopeptide repeats protein 1

1

1

High-throughput

0.407

High

1279063

TBC15
TBC1 domain family member 15

1

2

High-throughput

0.407

High

1279065

TB22A
TBC1 domain family member 22A

1

1

High-throughput

0.407

High

1279097

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.407

High

1279106

TNPO3
Transportin-3

1

1

High-throughput

0.407

High

270658

ATP9A
Probable phospholipid-transporting ATPase IIA

4

0

High-throughput

0.360

High

841205

CNDD3
Condensin-2 complex subunit D3

4

0

High-throughput

0.360

High

1233745

CNDH2
Condensin-2 complex subunit H2

4

0

High-throughput

0.360

High

1279092

DJC11
DnaJ homolog subfamily C member 11

4

0

High-throughput

0.360

High

1279093

RMND1
Required for meiotic nuclear division protein 1 homolog

4

0

High-throughput

0.360

High

1279078

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

3

0

High-throughput

0.347

High

1279103

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

3

0

High-throughput

0.347

High

1279048

CNDG2
Condensin-2 complex subunit G2

3

0

High-throughput

0.339

High

602238

TMM11
Transmembrane protein 11, mitochondrial

3

0

High-throughput

0.337

High

1060186

B2CL1
Bcl-2-like protein 1

2

0

High-throughput

0.316

High

1279096

NINJ2
Ninjurin-2

2

0

High-throughput

0.316

High

1279102

TEFF2
Tomoregulin-2

2

0

High-throughput

0.316

High

1279089

ST7
Suppressor of tumorigenicity 7 protein

2

0

High-throughput

0.298

High

63344

A5D903
PRB1 protein

1

0

High-throughput

0.268

Low

407917

PRP1
Basic salivary proline-rich protein 1

1

0

High-throughput

0.251

Low

170213

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

334041

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.249

Low

334819

IPO7
Importin-7

1

0

High-throughput

0.249

Low

353419

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

732828

GLPK
Glycerol kinase

1

0

High-throughput

0.249

Low

1060536

KLC1
Kinesin light chain 1

1

0

Small-scale

0.249

Low

1278658

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.249

Low

1279046

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.249

Low

1279087

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

1279107

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.249

Low

133766

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.232

Low

161627

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

0

High-throughput

0.232

Low

244372

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.232

Low

317873

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.232

Low

326966

UBE4B
Ubiquitin conjugation factor E4 B

1

0

High-throughput

0.232

Low

344415

TBCD8
TBC1 domain family member 8

1

0

High-throughput

0.232

Low

637917

NF1
Neurofibromin

1

0

High-throughput

0.232

Low

828389

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.232

Low

839473

PI4KA
Phosphatidylinositol 4-kinase alpha

1

0

High-throughput

0.232

Low

843710

HD
Huntingtin

1

0

High-throughput

0.232

Low

890851

TSC2
Tuberin

1

0

High-throughput

0.232

Low

951998

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.232

Low

1085241

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.232

Low

1208186

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

1

0

High-throughput

0.232

Low

1211161

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.232

Low

1218809

FOCAD
Focadhesin

1

0

High-throughput

0.232

Low

1224743

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.232

Low

1229168

INT3
Integrator complex subunit 3

1

0

High-throughput

0.232

Low

1233984

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

1

0

High-throughput

0.232

Low

1242072

TTC27
Tetratricopeptide repeat protein 27

1

0

High-throughput

0.232

Low

1251528

THADA
tRNA

1

0

High-throughput

0.232

Low

1275928

SETX
Probable helicase senataxin

1

0

High-throughput

0.232

Low

1279047

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

1279050

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.232

Low

1279051

CDAN1
Codanin-1

1

0

High-throughput

0.232

Low

1279053

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.232

Low

1279055

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.232

Low

1279064

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low

1279066

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.232

Low

1279069

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.232

Low

1279072

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.232

Low

1279073

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

1279074

INT4
Integrator complex subunit 4

1

0

High-throughput

0.232

Low

1279077

CND3
Condensin complex subunit 3

1

0

High-throughput

0.232

Low

1279080

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.232

Low

1279081

XPO4
Exportin-4

1

0

High-throughput

0.232

Low

1279082

INT2
Integrator complex subunit 2

1

0

High-throughput

0.232

Low

1279085

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.232

Low

1279088

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.232

Low

1279090

DIAP3
Protein diaphanous homolog 3

1

0

High-throughput

0.232

Low

1279091

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.232

Low

1279095

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.232

Low

1279100

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.232

Low

1279101

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025