Protein: SPA2
Protein SPA2

Gene: SPA2
Organism: Saccharomyces cerevisiae S288C
Interactions: 77
UniProt ID: P23201

Gene Ontology (top 5):
GO:0000131 - incipient cellular bud site
GO:0000133 - polarisome
GO:0005078 - MAP-kinase scaffold activity
GO:0005826 - actomyosin contractile ring
GO:0005934 - cellular bud tip

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

654698

SPA2
Protein SPA2

4

17

Small-scale

0.902

High

654723

PEA2
Protein PEA2

7

0

Small-scale

0.715

High

623772

MYO2
Myosin-2

4

7

Small-scale

0.677

High

654733

GYP3
GTPase-activating protein GYP3

3

3

Small-scale

0.658

High

654753

MSB4
GTPase-activating protein MSB4

3

2

Small-scale

0.641

High

654740

SLT2
Mitogen-activated protein kinase SLT2/MPK1

3

9

Small-scale

0.637

High

654719

YM11
Uncharacterized protein YMR124W

3

0

Small-scale

0.636

High

654708

MKK1
MAP kinase kinase MKK1/SSP32

2

11

Small-scale

0.625

High

654726

BUD6
Bud site selection protein 6

2

1

Small-scale

0.619

High

654717

KEL1
Kelch repeat-containing protein 1

2

9

High-throughput

0.613

High

654730

YFI6
Uncharacterized protein YFR016C

2

16

Small-scale

0.595

High

477515

MYO1
Myosin-1

2

8

Small-scale

0.584

High

654743

CYK2
Cytokinesis protein 2

1

1

Small-scale

0.573

High

654707

IMB3
Importin subunit beta-3

2

3

High-throughput

0.567

High

364340

CDK1
Cyclin-dependent kinase 1

1

4

High-throughput

0.561

High

654727

BNI1
Protein BNI1

1

3

Small-scale

0.552

High

571027

CHS2
Chitin synthase 2

1

0

Small-scale

0.549

High

654744

CYK3
Cytokinesis protein 3

1

0

Small-scale

0.549

High

654742

TOM1
E3 ubiquitin-protein ligase TOM1

2

8

High-throughput

0.549

High

654720

BEM2
GTPase-activating protein BEM2/IPL2

1

1

High-throughput

0.515

High

448851

STE7
Serine/threonine-protein kinase STE7

1

17

Small-scale

0.508

High

654699

STE11
Serine/threonine-protein kinase STE11

1

3

Small-scale

0.508

High

654709

MKK2
MAP kinase kinase MKK2/SSP33

1

11

Small-scale

0.508

High

654722

FIR1
Factor interacting with REF2

1

0

Small-scale

0.504

High

654711

HSP7F
Heat shock protein homolog SSE1

2

13

High-throughput

0.504

High

654738

ACT
Actin

1

11

Small-scale

0.501

High

654704

XPO1
Exportin-1

1

4

High-throughput

0.489

High

654745

SHS1
Seventh homolog of septin 1

1

0

Small-scale

0.486

High

654703

BEM1
Bud emergence protein 1

1

17

Small-scale

0.481

High

654741

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

10

High-throughput

0.481

High

599326

FUS3
Mitogen-activated protein kinase FUS3

1

8

Small-scale

0.479

High

645874

DBF2
Cell cycle protein kinase DBF2

1

11

High-throughput

0.479

High

654710

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

12

Small-scale

0.479

High

654735

SSK2
MAP kinase kinase kinase SSK2

1

8

Small-scale

0.479

High

654751

IQG1
Ras GTPase-activating-like protein IQG1

1

5

Small-scale

0.479

High

654754

LAS17
Proline-rich protein LAS17

1

7

Small-scale

0.479

High

654712

MRE11
Double-strand break repair protein MRE11

1

2

High-throughput

0.470

High

654725

NDC80
Kinetochore protein NDC80

1

10

High-throughput

0.464

High

654729

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

High-throughput

0.464

High

654728

SPR3
Sporulation-regulated protein 3

1

0

High-throughput

0.460

High

654736

INN1
Ingression protein 1

1

0

Small-scale

0.458

High

517899

SSBP1
Single-stranded nucleic acid-binding protein

1

8

High-throughput

0.457

High

598373

TUP1
General transcriptional corepressor TUP1

1

12

High-throughput

0.439

High

654705

ZIP1
Synaptonemal complex protein ZIP1

1

7

High-throughput

0.439

High

654718

IFH1
Protein IFH1

1

10

High-throughput

0.439

High

654737

NST1
Stress response protein NST1

1

13

High-throughput

0.439

High

654755

CAF1A
Chromatin assembly factor 1 subunit A

1

3

High-throughput

0.439

High

512266

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

578874

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.437

High

594196

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

654700

BPH1
Beige protein homolog 1

1

4

High-throughput

0.437

High

654706

HS104
Heat shock protein 104

1

1

Small-scale

0.437

High

654713

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

5

High-throughput

0.437

High

654716

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

Small-scale

0.437

High

654724

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.437

High

654734

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

654739

H3
Histone H3

1

20

High-throughput

0.437

High

654747

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

654748

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

654752

SMT3
Ubiquitin-like protein SMT3

1

5

High-throughput

0.437

High

561247

CG13
G1/S-specific cyclin CLN3

1

2

High-throughput

0.417

High

481487

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.407

High

525956

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.407

High

654701

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.407

High

654721

HSP7E
Heat shock protein SSC3, mitochondrial

1

13

High-throughput

0.407

High

654715

CND2
Condensin complex subunit 2

1

0

Small-scale

0.279

Low

370457

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

0

High-throughput

0.265

Low

654746

SGO1
Shugoshin

1

0

High-throughput

0.251

Low

654749

SRL2
Protein SRL2

1

0

High-throughput

0.251

Low

434840

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435782

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

654702

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

654714

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

Small-scale

0.249

Low

654731

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

Small-scale

0.249

Low

654732

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

654750

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025