Protein: GIN4
Serine/threonine-protein kinase GIN4 (EC 2.7.11.1) (Growth inhibitory protein 4)

Gene: GIN4
Organism: Saccharomyces cerevisiae S288C
Interactions: 133
UniProt ID: Q12263

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000920 - septum digestion after cytokinesis
GO:0000921 - septin ring assembly
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800635

RIM11
Serine/threonine-protein kinase RIM11/MSD1

3

10

High-throughput

0.867

High

364814

CDK1
Cyclin-dependent kinase 1

3

3

Small-scale

0.858

High

758345

HSL1
Probable serine/threonine-protein kinase HSL1

2

16

High-throughput

0.793

High

745288

ELM1
Serine/threonine-protein kinase ELM1

2

17

Small-scale

0.767

High

670360

NAP1
Nucleosome assembly protein

13

3

Small-scale

0.761

High

1038604

PDR12
ATP-dependent permease PDR12

2

0

High-throughput

0.751

High

1059803

SHS1
Seventh homolog of septin 1

6

16

Small-scale

0.743

High

737062

CDC3
Cell division control protein 3

5

5

Small-scale

0.722

High

672275

CDC10
Cell division control protein 10

5

9

Small-scale

0.720

High

737350

CDC12
Cell division control protein 12

5

5

Small-scale

0.720

High

737127

CDC11
Cell division control protein 11

4

14

Small-scale

0.702

High

667155

CG23
G2/mitotic-specific cyclin-3

1

2

High-throughput

0.691

High

738052

MKK1
MAP kinase kinase MKK1/SSP32

1

17

High-throughput

0.691

High

793373

PP2C4
Protein phosphatase 2C homolog 4

1

19

High-throughput

0.691

High

1030270

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

17

High-throughput

0.691

High

548737

RNA1
Ran GTPase-activating protein 1

1

2

High-throughput

0.647

High

923079

FPK1
Flippase kinase 1

1

17

Small-scale

0.647

High

925358

CRZ1
Transcriptional regulator CRZ1

1

3

High-throughput

0.647

High

1084692

ARP8
Actin-like protein ARP8

1

10

High-throughput

0.647

High

924395

BNI5
Bud neck protein 5

2

1

Small-scale

0.635

High

763241

PP2C1
Protein phosphatase 2C homolog 1

1

20

High-throughput

0.621

High

646572

RAD53
Serine/threonine-protein kinase RAD53

1

16

High-throughput

0.618

High

1026863

CDC14
Tyrosine-protein phosphatase CDC14

1

12

Small-scale

0.618

High

1084690

GIN4
Serine/threonine-protein kinase GIN4

1

17

Small-scale

0.618

High

755318

NUF2
Kinetochore protein NUF2

2

11

High-throughput

0.595

High

814157

SAW1
Single-strand annealing weakened protein 1

2

1

High-throughput

0.588

High

923787

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

0

High-throughput

0.586

High

393529

HSP82
ATP-dependent molecular chaperone HSP82

1

17

High-throughput

0.575

High

671742

SCJ1
DnaJ-related protein SCJ1

1

5

High-throughput

0.575

High

800781

RCK1
Serine/threonine-protein kinase RCK1

1

20

High-throughput

0.575

High

925141

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.575

High

752889

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

1044561

SPC19
DASH complex subunit SPC19

2

0

High-throughput

0.570

High

824676

BNR1
BNI1-related protein 1

1

5

Small-scale

0.561

High

826938

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

808568

TEM1
Protein TEM1

1

19

High-throughput

0.553

High

1084515

NBP2
NAP1-binding protein 2

1

2

High-throughput

0.527

High

600722

SEC2
Rab guanine nucleotide exchange factor SEC2

1

4

High-throughput

0.501

High

624472

RDS2
Regulator of drug sensitivity 2

1

2

High-throughput

0.501

High

673363

GLRX1
Glutaredoxin-1

1

2

High-throughput

0.501

High

692532

GYS2
Glycogen [starch] synthase isoform 2

1

1

High-throughput

0.501

High

701607

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

8

High-throughput

0.501

High

798518

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

1

1

Small-scale

0.501

High

826307

DOT5
Peroxiredoxin DOT5

1

4

High-throughput

0.501

High

918248

YG1B
Uncharacterized protein YGR017W

1

1

High-throughput

0.501

High

1046239

SEG1
Eisosome protein SEG1

1

1

High-throughput

0.501

High

1046692

HFD1
Fatty aldehyde dehydrogenase HFD1

1

2

High-throughput

0.501

High

1053855

YL345
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase

1

3

High-throughput

0.501

High

1060764

CMS1
Protein CMS1

1

1

High-throughput

0.501

High

1084352

SAS10
Something about silencing protein 10

1

1

High-throughput

0.501

High

521135

PRI1
DNA primase small subunit

1

0

High-throughput

0.493

High

751513

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.493

High

923931

VPS75
Vacuolar protein sorting-associated protein 75

1

0

High-throughput

0.493

High

1054912

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.493

High

753159

NIP80
Protein NIP100

1

19

High-throughput

0.481

High

924970

NIS1
Protein NIS1

1

1

Small-scale

0.481

High

672476

STE50
Protein STE50

1

0

Small-scale

0.480

High

1035257

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.480

High

1057093

MDM36
Mitochondrial distribution and morphology protein 36

1

0

High-throughput

0.480

High

150015

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

435439

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

436233

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

514892

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

674896

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

708542

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

778593

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

779373

CENPA
Histone H3-like centromeric protein CSE4

1

5

High-throughput

0.479

High

792312

GBLP
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.479

High

800684

KPR2
Ribose-phosphate pyrophosphokinase 2

1

7

High-throughput

0.479

High

802449

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

811196

TCPZ
T-complex protein 1 subunit zeta

1

7

High-throughput

0.479

High

812140

DHH1
ATP-dependent RNA helicase DHH1

1

5

High-throughput

0.479

High

825308

MOB1
DBF2 kinase activator protein MOB1

1

2

High-throughput

0.479

High

963793

H3
Histone H3

1

5

High-throughput

0.479

High

1033633

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

1051625

HRQ1
ATP-dependent helicase HRQ1

1

3

Small-scale

0.479

High

1054011

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

1059422

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.479

High

585410

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.470

High

804102

GIC1
GTPase-interacting component 1

1

0

Small-scale

0.460

High

1046206

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.460

High

1055783

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

1084694

AIM44
Altered inheritance of mitochondria protein 44

1

0

Small-scale

0.460

High

590754

HSP26
Heat shock protein 26

1

0

Small-scale

0.458

High

850527

ECO1
N-acetyltransferase ECO1

1

0

Small-scale

0.458

High

865791

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

874592

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

1031770

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

1084661

YL054
Uncharacterized transcriptional regulatory protein YLL054C

1

0

Small-scale

0.458

High

619183

IF5A2
Eukaryotic translation initiation factor 5A-2

1

1

High-throughput

0.457

High

1046746

SEC13
Protein transport protein SEC13

1

3

High-throughput

0.457

High

1055584

ARV1
Protein ARV1

1

1

High-throughput

0.457

High

525564

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

528029

HSP72
Heat shock protein SSA2

1

14

High-throughput

0.445

High

546762

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

727406

HS104
Heat shock protein 104

1

5

High-throughput

0.445

High

742687

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

804562

SSZ1
Ribosome-associated complex subunit SSZ1

1

7

High-throughput

0.445

High

816473

HSP7E
Heat shock protein SSC3, mitochondrial

1

10

High-throughput

0.445

High

820130

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

824588

6P21
6-phosphofructo-2-kinase 1

1

4

High-throughput

0.445

High

1056568

IMH1
Golgin IMH1

1

20

High-throughput

0.439

High

1055007

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.438

High

410399

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433905

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

442174

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

503305

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504475

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

513285

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

747638

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

753655

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

877940

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

1064829

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

779894

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.282

High

583770

SEC11
Signal peptidase complex catalytic subunit SEC11

1

0

High-throughput

0.269

Low

399893

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.261

Low

478436

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.261

Low

659166

MBR1
Mitochondrial biogenesis regulation protein 1

1

0

High-throughput

0.261

Low

805114

RPF1
Ribosome production factor 1

1

0

High-throughput

0.261

Low

1044100

NUP53
Nucleoporin NUP53

1

0

High-throughput

0.261

Low

1084693

MPD1
Protein disulfide-isomerase MPD1

1

0

High-throughput

0.261

Low

800367

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.251

Low

849712

FMP32
Protein FMP32, mitochondrial

1

0

High-throughput

0.251

Low

1049975

IVY1
Protein IVY1

1

0

High-throughput

0.251

Low

1061375

YL031
Putative uncharacterized protein YLR031W

1

0

High-throughput

0.251

Low

1084691

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.251

Low

1084695

MPD2
Protein disulfide isomerase MPD2

1

0

High-throughput

0.251

Low

383950

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

455320

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

689725

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

780811

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

865866

ACF4
Assembly-complementing factor 4

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025