Protein: NOT2
General negative regulator of transcription subunit 2 (cell division cycle protein 36)

Gene: NOT2, CDC36
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P06100

Gene Ontology (top 5):
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000749 - response to pheromone triggering conjugation with cellular fusion
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

438126

NOT1
General negative regulator of transcription subunit 1

13

8

Small-scale

0.980

High

438172

NOT5
General negative regulator of transcription subunit 5

8

8

Small-scale

0.974

High

438116

NOT3
General negative regulator of transcription subunit 3

6

8

Small-scale

0.943

High

438115

NOT2
General negative regulator of transcription subunit 2

2

9

Small-scale

0.757

High

438159

CAF40
Protein CAF40

9

7

Small-scale

0.751

High

438136

NOT4
General negative regulator of transcription subunit 4

8

3

Small-scale

0.745

High

438129

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

6

10

Small-scale

0.730

High

438142

POP2
Poly(A) ribonuclease POP2

5

10

Small-scale

0.710

High

438125

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

5

High-throughput

0.541

High

438158

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

438165

MRD1
Multiple RNA-binding domain-containing protein 1

1

3

High-throughput

0.536

High

438135

PIN4
RNA-binding protein PIN4

1

0

High-throughput

0.518

High

438138

DID4
DOA4-independent degradation protein 4

1

0

High-throughput

0.518

High

438160

ADA2
SAGA complex subunit ADA2

1

1

Small-scale

0.518

High

438121

TBP
TATA-box-binding protein

1

1

Small-scale

0.515

High

438154

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

2

Small-scale

0.515

High

438162

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

3

Small-scale

0.508

High

437856

KAPC
cAMP-dependent protein kinase type 3

1

1

High-throughput

0.501

High

438143

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

Small-scale

0.486

High

438120

TAF13
Transcription initiation factor TFIID subunit 13

1

1

Small-scale

0.481

High

401805

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

438122

DBP5
ATP-dependent RNA helicase DBP5

1

2

Small-scale

0.479

High

438124

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

438127

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

438133

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

438137

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

438139

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.479

High

438147

NACB2
Nascent polypeptide-associated complex subunit beta-2

1

3

High-throughput

0.479

High

438148

RRP41
Exosome complex component SKI6

1

1

Small-scale

0.479

High

438150

MTR4
ATP-dependent RNA helicase DOB1

1

3

Small-scale

0.479

High

438157

CF130
Protein CAF130

1

1

High-throughput

0.479

High

438163

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

438169

YRA1
RNA annealing protein YRA1

1

1

Small-scale

0.479

High

438171

RRP42
Exosome complex component RRP42

1

2

Small-scale

0.479

High

438174

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

4

Small-scale

0.479

High

438130

MSB2
Signaling mucin MSB2

1

4

High-throughput

0.464

High

438123

DBF2
Cell cycle protein kinase DBF2

1

0

Small-scale

0.460

High

438145

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

438118

METK1
S-adenosylmethionine synthase 1

1

0

Small-scale

0.458

High

438128

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

438132

NUP2
Nucleoporin NUP2

1

0

Small-scale

0.458

High

438134

MFT1
THO complex subunit MFT1

1

0

Small-scale

0.458

High

438151

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

438166

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

438170

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

438140

GIC1
GTPase-interacting component 1

1

1

High-throughput

0.457

High

438117

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

438119

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

438146

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

438153

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.438

High

438168

SOG2
Leucine-rich repeat-containing protein SOG2

1

0

High-throughput

0.438

High

438152

YJY1
Uncharacterized protein YJR011C

1

1

High-throughput

0.437

High

438161

MLP1
Protein MLP1

1

1

Small-scale

0.437

High

438167

GIC2
GTPase-interacting component 2

1

1

High-throughput

0.417

High

438131

ATP11
Protein ATP11, mitochondrial

2

0

High-throughput

0.313

High

438141

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.288

High

438144

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

438155

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

438149

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

438156

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.238

Low

438164

GPI19
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19

1

0

High-throughput

0.238

Low

438173

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025