Protein: TAF4
Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)

Gene: TAF4
Organism: Homo sapiens
Interactions: 141
UniProt ID: O00268

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001541 - ovarian follicle development
GO:0001673 - male germ cell nucleus
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130759

TAF12
Transcription initiation factor TFIID subunit 12

7

6

Small-scale

0.972

High

130699

TBP
TATA-box-binding protein

10

4

Small-scale

0.970

High

130772

TAF8
Transcription initiation factor TFIID subunit 8

7

5

Small-scale

0.961

High

130760

TAF9
Transcription initiation factor TFIID subunit 9

2

2

Small-scale

0.767

High

130740

TAF10
Transcription initiation factor TFIID subunit 10

5

4

Small-scale

0.704

High

130766

TAF3
Transcription initiation factor TFIID subunit 3

1

11

High-throughput

0.691

High

130700

TAF1
Transcription initiation factor TFIID subunit 1

4

13

Small-scale

0.689

High

130764

TAF7L
Transcription initiation factor TFIID subunit 7-like

3

4

High-throughput

0.662

High

130673

TAF4
Transcription initiation factor TFIID subunit 4

1

10

Small-scale

0.647

High

130733

H31
Histone H3.1

3

20

High-throughput

0.640

High

130685

ESR1
Estrogen receptor

3

20

High-throughput

0.633

High

130712

HD
Huntingtin

2

2

Small-scale

0.631

High

130679

SUPT3
Transcription initiation protein SPT3 homolog

1

2

Small-scale

0.618

High

130721

TF2AA
Transcription initiation factor IIA subunit 1

1

2

High-throughput

0.618

High

130729

TBPL1
TATA box-binding protein-like 1

1

4

High-throughput

0.618

High

130755

TAF13
Transcription initiation factor TFIID subunit 13

1

2

High-throughput

0.618

High

130756

TAF11
Transcription initiation factor TFIID subunit 11

1

3

Small-scale

0.618

High

130722

T2AG
Transcription initiation factor IIA subunit 2

1

0

Small-scale

0.614

High

130754

TAF5
Transcription initiation factor TFIID subunit 5

2

13

Small-scale

0.594

High

130688

SP1
Transcription factor Sp1

2

7

Small-scale

0.586

High

130678

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

130692

EF2
Elongation factor 2

2

1

High-throughput

0.584

High

130701

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

Small-scale

0.584

High

130730

H4
Histone H4

2

6

High-throughput

0.584

High

130747

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

130750

BRD3
Bromodomain-containing protein 3

2

18

High-throughput

0.584

High

130714

CBX5
Chromobox protein homolog 5

1

13

Small-scale

0.573

High

130743

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

7

High-throughput

0.571

High

130762

H31T
Histone H3.1t

2

20

Small-scale

0.563

High

130697

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

7

Small-scale

0.561

High

130778

ZCH10
Zinc finger CCHC domain-containing protein 10

2

2

High-throughput

0.549

High

130794

SPT25
Spermatogenesis-associated protein 25

2

1

High-throughput

0.549

High

130677

CREB3
Cyclic AMP-responsive element-binding protein 3

1

2

Small-scale

0.536

High

130687

JUN
Transcription factor Jun

1

9

Small-scale

0.536

High

130681

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

High-throughput

0.536

High

130713

MAGA9
Melanoma-associated antigen 9

1

4

High-throughput

0.536

High

130751

RNPS1
RNA-binding protein with serine-rich domain 1

1

2

High-throughput

0.536

High

130780

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

4

High-throughput

0.536

High

130783

KIFA3
Kinesin-associated protein 3

1

6

High-throughput

0.536

High

130798

ZHANG
CREB/ATF bZIP transcription factor

1

0

Small-scale

0.513

High

130694

TFE2
Transcription factor E2-alpha

1

1

Small-scale

0.501

High

130708

AHR
Aryl hydrocarbon receptor

1

6

Small-scale

0.501

High

130736

CREM
cAMP-responsive element modulator

1

2

Small-scale

0.501

High

130790

HTF4
Transcription factor 12

1

1

Small-scale

0.501

High

130718

TAF6
Transcription initiation factor TFIID subunit 6

1

2

Small-scale

0.500

High

65648

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

1

High-throughput

0.479

High

130674

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

130675

SR140
U2 snRNP-associated SURP motif-containing protein

1

2

High-throughput

0.479

High

130682

KLF8
Krueppel-like factor 8

1

12

High-throughput

0.479

High

130683

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.479

High

130684

EGFR
Epidermal growth factor receptor

1

14

High-throughput

0.479

High

130686

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

130689

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

130690

H2AZ
Histone H2A.Z

1

8

High-throughput

0.479

High

130691

H2A1
Histone H2A type 1

1

6

High-throughput

0.479

High

130695

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

130696

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.479

High

130698

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

130702

BRD2
Bromodomain-containing protein 2

1

18

High-throughput

0.479

High

130703

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.479

High

130704

PML
Protein PML

1

6

High-throughput

0.479

High

130705

ELF1
ETS-related transcription factor Elf-1

1

15

High-throughput

0.479

High

130706

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

130707

SOX6
Transcription factor SOX-6

1

13

Small-scale

0.479

High

130709

ETV3
ETS translocation variant 3

1

13

High-throughput

0.479

High

130710

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

130711

ELK3
ETS domain-containing protein Elk-3

1

15

High-throughput

0.479

High

130715

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

130716

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

130717

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.479

High

130719

CDK7
Cyclin-dependent kinase 7

1

3

High-throughput

0.479

High

130723

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

130724

KLF3
Krueppel-like factor 3

1

12

High-throughput

0.479

High

130725

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

130727

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

130728

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.479

High

130731

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.479

High

130732

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

3

High-throughput

0.479

High

130734

H33
Histone H3.3

1

20

High-throughput

0.479

High

130735

EWS
RNA-binding protein EWS

1

9

High-throughput

0.479

High

130737

TLE3
Transducin-like enhancer protein 3

1

13

High-throughput

0.479

High

130738

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

130741

IKZF1
DNA-binding protein Ikaros

1

2

High-throughput

0.479

High

130742

ROCK1
Rho-associated protein kinase 1

1

7

High-throughput

0.479

High

130744

CUL3
Cullin-3

1

6

High-throughput

0.479

High

130746

NFYC
Nuclear transcription factor Y subunit gamma

1

1

High-throughput

0.479

High

130749

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

130752

SF3B3
Splicing factor 3B subunit 3

1

1

Small-scale

0.479

High

130753

SF3A1
Splicing factor 3A subunit 1

1

9

High-throughput

0.479

High

130757

TAF7
Transcription initiation factor TFIID subunit 7

1

4

Small-scale

0.479

High

130761

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

130767

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

130768

H2A2A
Histone H2A type 2-A

1

6

High-throughput

0.479

High

130770

FBX38
F-box only protein 38

1

1

High-throughput

0.479

High

130771

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

130774

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

7

High-throughput

0.479

High

130775

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

130776

FBX22
F-box only protein 22

1

5

High-throughput

0.479

High

130777

NUP43
Nucleoporin Nup43

1

16

High-throughput

0.479

High

130779

PHIP
PH-interacting protein

1

14

High-throughput

0.479

High

130781

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

130782

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

130784

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

130786

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

13

High-throughput

0.479

High

130787

CDCA5
Sororin

1

1

High-throughput

0.479

High

130788

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

130791

FEV
Protein FEV

1

12

High-throughput

0.479

High

130792

ELF4
ETS-related transcription factor Elf-4

1

15

High-throughput

0.479

High

130793

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

130795

KLF16
Krueppel-like factor 16

1

9

High-throughput

0.479

High

130796

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

130799

NLE1
Notchless protein homolog 1

1

7

High-throughput

0.479

High

130801

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

130802

PD1L1
Programmed cell death 1 ligand 1

1

3

Small-scale

0.479

High

130803

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

130804

KLF15
Krueppel-like factor 15

1

13

High-throughput

0.479

High

130805

IKZF3
Zinc finger protein Aiolos

1

2

High-throughput

0.479

High

130807

E41L3
Band 4.1-like protein 3

1

7

High-throughput

0.479

High

130809

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.479

High

130676

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

130680

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

130693

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.458

High

130739

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

130745

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

130748

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

130769

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

130789

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

130797

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

130806

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

130720

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.445

High

130726

WDR5
WD repeat-containing protein 5

1

13

Small-scale

0.445

High

130763

KLH22
Kelch-like protein 22

1

3

High-throughput

0.445

High

130765

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

Small-scale

0.445

High

130800

SPHK1
Sphingosine kinase 1

1

1

Small-scale

0.445

High

130808

TRRAP
Transformation/transcription domain-associated protein

1

5

Small-scale

0.445

High

104803

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

130758

RHOH
Rho-related GTP-binding protein RhoH

1

14

High-throughput

0.437

High

130773

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

5

Small-scale

0.437

High

130785

MOAP1
Modulator of apoptosis 1

1

0

High-throughput

0.426

High

87269

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025