Protein: CYBC1
Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros)

Gene: CYBC1
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9BQA9

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0045087 - innate immune response
GO:0045728 - respiratory burst after phagocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416970

CY24B
NADPH oxidase 2

2

1

High-throughput

0.783

High

1410436

NOX3
NADPH oxidase 3

2

1

High-throughput

0.700

High

1405345

P2RX4
P2X purinoceptor 4

3

1

High-throughput

0.609

High

1279358

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

1

High-throughput

0.606

High

1333972

DHB11
Estradiol 17-beta-dehydrogenase 11

2

1

High-throughput

0.606

High

230410

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.590

High

144477

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

166992

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.580

High

180029

BET1
BET1 homolog

2

0

High-throughput

0.580

High

1050055

PLP2
Proteolipid protein 2

2

0

High-throughput

0.580

High

1155031

ADIPO
Adiponectin

2

0

High-throughput

0.580

High

1247405

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.580

High

1327943

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

1328188

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1328716

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.580

High

1358707

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

0

High-throughput

0.580

High

1410430

APOL2
Apolipoprotein L2

2

0

High-throughput

0.580

High

1410441

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.580

High

1410443

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

1410444

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

1410445

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.580

High

349636

TSN12
Tetraspanin-12

2

1

High-throughput

0.553

High

622098

CD53
Leukocyte surface antigen CD53

2

1

High-throughput

0.553

High

904238

P2RX1
P2X purinoceptor 1

2

1

High-throughput

0.553

High

1210301

MF14B
Hippocampus abundant transcript-like protein 1

2

1

High-throughput

0.553

High

1399952

AQP10
Aquaporin-10

2

1

High-throughput

0.553

High

1382168

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1410438

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.513

High

1363215

AQP3
Aquaporin-3

1

1

High-throughput

0.489

High

1410439

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.489

High

1384340

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

1

High-throughput

0.481

High

679390

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.426

High

844960

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.407

High

876440

EAA4
Excitatory amino acid transporter 4

1

1

High-throughput

0.407

High

1397962

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

1329436

KASH5
Protein KASH5

3

0

High-throughput

0.352

High

913263

TF2AA
Transcription initiation factor IIA subunit 1

3

0

High-throughput

0.347

High

821763

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

142108

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.316

High

188977

TMPS2
Transmembrane protease serine 2

2

0

High-throughput

0.316

High

220411

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.316

High

253105

PLIN3
Perilipin-3

2

0

High-throughput

0.316

High

275090

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

0

High-throughput

0.316

High

317112

AQP8
Aquaporin-8

2

0

High-throughput

0.316

High

337903

CLD7
Claudin-7

2

0

High-throughput

0.316

High

387554

APOA2
Apolipoprotein A-II

2

0

High-throughput

0.316

High

451670

TRBM
Thrombomodulin

2

0

High-throughput

0.316

High

592738

LEUK
Leukosialin

2

0

High-throughput

0.316

High

746218

STX2
Syntaxin-2

2

0

High-throughput

0.316

High

850849

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

0

High-throughput

0.316

High

870775

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.316

High

949284

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.316

High

1094868

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.316

High

1109028

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1203337

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

1207592

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1281187

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

1308656

AHNK2
Protein AHNAK2

2

0

High-throughput

0.316

High

1312813

NRM
Nurim

2

0

High-throughput

0.316

High

1331499

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.316

High

1335832

APCDL
Protein APCDD1-like

2

0

High-throughput

0.316

High

1351691

GP152
Probable G-protein coupled receptor 152

2

0

High-throughput

0.316

High

1351761

GP151
G-protein coupled receptor 151

2

0

High-throughput

0.316

High

1359309

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.316

High

1387362

SHSA4
Protein shisa-4

2

0

High-throughput

0.316

High

1388142

T4S19
Transmembrane 4 L6 family member 19

2

0

High-throughput

0.316

High

1393132

TMM80
Transmembrane protein 80

2

0

High-throughput

0.316

High

1410431

LXN
Latexin

2

0

High-throughput

0.316

High

1410433

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

1410435

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

1410437

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

1410440

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.316

High

1410442

NINJ2
Ninjurin-2

2

0

High-throughput

0.316

High

1331846

SYT2
Synaptotagmin-2

2

0

High-throughput

0.313

High

577498

ETS1
Protein C-ets-1

1

0

High-throughput

0.301

High

940053

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

1152228

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.279

Low

1163506

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.279

Low

1211199

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.279

Low

1286616

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.279

Low

1346625

VANG1
Vang-like protein 1

1

0

High-throughput

0.279

Low

1410434

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.279

Low

386154

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

1352506

GPX8
Probable glutathione peroxidase 8

1

0

High-throughput

0.251

Low

1005026

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1163867

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.249

Low

1255268

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1410432

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.238

Low

248933

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

259071

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.232

Low

469537

SYPH
Synaptophysin

1

0

High-throughput

0.232

Low

848555

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025