Protein: WRIP1
ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)

Gene: WRIP1, WRNIP1
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q96S55

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006261 - DNA-templated DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508481

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

5

Small-scale

0.927

High

551213

PCNA
Proliferating cell nuclear antigen

2

15

Small-scale

0.768

High

242665

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

1402237

WRIP1
ATPase WRNIP1

1

16

Small-scale

0.690

High

372911

MYC
Myc proto-oncogene protein

3

4

High-throughput

0.640

High

386128

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

1

High-throughput

0.640

High

345104

RIGI
Antiviral innate immune response receptor RIG-I

2

3

High-throughput

0.639

High

260336

BRD4
Bromodomain-containing protein 4

1

15

High-throughput

0.618

High

342296

BRD1
Bromodomain-containing protein 1

1

14

High-throughput

0.618

High

639802

TAF1
Transcription initiation factor TFIID subunit 1

1

4

High-throughput

0.618

High

935030

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.618

High

703034

DPOD1
DNA polymerase delta catalytic subunit

2

1

Small-scale

0.611

High

831278

CCNF
Cyclin-F

2

3

High-throughput

0.601

High

487656

PARP1
Poly [ADP-ribose] polymerase 1

2

13

High-throughput

0.584

High

1280421

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

8

Small-scale

0.584

High

1402254

RAD18
E3 ubiquitin-protein ligase RAD18

2

1

Small-scale

0.584

High

1402258

MCM9
DNA helicase MCM9

2

7

Small-scale

0.584

High

641660

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

6

High-throughput

0.576

High

1364859

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

3

1

High-throughput

0.576

High

1122949

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

4

Small-scale

0.573

High

1389353

RNF31
E3 ubiquitin-protein ligase RNF31

2

8

Small-scale

0.571

High

1402246

TOLIP
Toll-interacting protein

1

0

High-throughput

0.561

High

1121309

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.552

High

322675

KDM4B
Lysine-specific demethylase 4B

1

9

High-throughput

0.536

High

938023

FOXA3
Hepatocyte nuclear factor 3-gamma

1

2

High-throughput

0.536

High

1129179

IRF3
Interferon regulatory factor 3

1

1

High-throughput

0.536

High

1287872

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.536

High

1387262

HDA11
Histone deacetylase 11

1

3

High-throughput

0.536

High

1402239

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1402245

FOXP3
Forkhead box protein P3

1

3

High-throughput

0.536

High

1402251

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.536

High

1402264

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

2

High-throughput

0.536

High

900108

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

907541

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.515

High

1402242

OSB10
Oxysterol-binding protein-related protein 10

1

0

High-throughput

0.513

High

1402244

RNF26
E3 ubiquitin-protein ligase RNF26

1

6

Small-scale

0.501

High

878277

DPOD2
DNA polymerase delta subunit 2

1

1

Small-scale

0.500

High

1153881

SMAD2
Mothers against decapentaplegic homolog 2

1

0

Small-scale

0.493

High

1353527

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

2

Small-scale

0.484

High

362353

ABL1
Tyrosine-protein kinase ABL1

1

0

Small-scale

0.480

High

1109363

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.480

High

1402252

DPOD4
DNA polymerase delta subunit 4

1

0

Small-scale

0.479

High

173256

XPO1
Exportin-1

1

9

High-throughput

0.479

High

412471

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

520310

ANDR
Androgen receptor

1

9

High-throughput

0.479

High

589471

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

696279

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

714367

PML
Protein PML

1

5

High-throughput

0.479

High

731553

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

799417

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

800063

COIL
Coilin

1

1

High-throughput

0.479

High

855504

ATRX
Transcriptional regulator ATRX

1

9

Small-scale

0.479

High

888266

MCM2
DNA replication licensing factor MCM2

1

2

Small-scale

0.479

High

1083426

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

High-throughput

0.479

High

1088985

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1095762

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

Small-scale

0.479

High

1096794

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

1114078

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1121852

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.479

High

1135779

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1255167

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1257888

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

3

Small-scale

0.479

High

1276677

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1278082

MAVS
Mitochondrial antiviral-signaling protein

1

7

High-throughput

0.479

High

1287006

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

5

Small-scale

0.479

High

1294556

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

2

High-throughput

0.479

High

1314375

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1329823

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1332699

ZBT38
Zinc finger and BTB domain-containing protein 38

1

3

Small-scale

0.479

High

1340787

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1367080

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1368070

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

1387507

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

1397328

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1401353

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1402247

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

8

Small-scale

0.479

High

1402250

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1402259

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1402260

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1402263

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1402269

TRAF6
TNF receptor-associated factor 6

1

4

Small-scale

0.479

High

1402270

ARI1
E3 ubiquitin-protein ligase ARIH1

1

8

High-throughput

0.479

High

143687

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.458

High

213539

ATMIN
ATM interactor

1

0

Small-scale

0.458

High

281241

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.458

High

342017

CEP43
Centrosomal protein 43

1

0

Small-scale

0.458

High

667418

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

705723

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.458

High

945299

NU107
Nuclear pore complex protein Nup107

1

0

Small-scale

0.458

High

995781

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1097509

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1384808

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1397699

PRIPO
DNA-directed primase/polymerase protein

1

0

Small-scale

0.458

High

1402240

EYA3
Protein phosphatase EYA3

1

0

High-throughput

0.458

High

1402243

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1402261

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.458

High

1402267

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

167957

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.445

High

177929

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

2

Small-scale

0.445

High

273447

KDM4A
Lysine-specific demethylase 4A

1

9

Small-scale

0.445

High

396763

ESR1
Estrogen receptor

1

9

High-throughput

0.445

High

564254

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

911063

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.445

High

1090870

TRAF2
TNF receptor-associated factor 2

1

5

Small-scale

0.445

High

1209538

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1337921

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

1397955

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.445

High

1402253

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.445

High

1402262

TRI10
Tripartite motif-containing protein 10

1

1

High-throughput

0.445

High

1402271

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.445

High

701460

5HT2A
5-hydroxytryptamine receptor 2A

1

1

Small-scale

0.437

High

768955

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

835465

5HT2B
5-hydroxytryptamine receptor 2B

1

1

Small-scale

0.437

High

1178323

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1235499

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.437

High

1249138

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1338913

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.437

High

1402241

EPAS1
Endothelial PAS domain-containing protein 1

1

5

Small-scale

0.437

High

1402249

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1402256

NLE1
Notchless protein homolog 1

1

2

High-throughput

0.437

High

174197

SYN3
Synapsin-3

1

0

High-throughput

0.426

High

679385

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.426

High

943537

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

0

High-throughput

0.426

High

1010520

EREP3
Protein ENTREP3

1

0

High-throughput

0.426

High

1140232

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.426

High

1208667

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.426

High

1273789

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

1329182

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.426

High

1358020

TM171
Transmembrane protein 171

1

0

High-throughput

0.426

High

1402255

RN146
E3 ubiquitin-protein ligase RNF146

1

0

High-throughput

0.426

High

1402265

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.426

High

887149

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

922605

AP2S1
AP-2 complex subunit sigma

1

2

High-throughput

0.407

High

1325787

FXL16
F-box/LRR-repeat protein 16

1

3

High-throughput

0.407

High

1381017

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

1402248

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

1

High-throughput

0.407

High

1155029

ADIPO
Adiponectin

2

0

High-throughput

0.313

High

378172

TNFA
Tumor necrosis factor

2

0

Small-scale

0.310

High

1402238

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

472347

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

1332882

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1357526

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1402266

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

286712

STX11
Syntaxin-11

1

0

High-throughput

0.232

Low

295624

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

1239279

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1331010

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

1

0

High-throughput

0.232

Low

1384111

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.232

Low

1384215

LDAF1
Lipid droplet assembly factor 1

1

0

High-throughput

0.232

Low

1402257

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1402268

SPAT2
Spermatogenesis-associated protein 2

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025