Protein: UBE4B
Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)

Gene: UBE4B
Organism: Homo sapiens
Interactions: 91
UniProt ID: O95155

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0003222 - ventricular trabecula myocardium morphogenesis
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

326942

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.949

High

326941

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.937

High

326908

UBE4B
Ubiquitin conjugation factor E4 B

4

14

Small-scale

0.888

High

326938

TERA
Transitional endoplasmic reticulum ATPase

11

10

Small-scale

0.757

High

326915

P53
Cellular tumor antigen p53

4

7

Small-scale

0.705

High

326975

UBL7
Ubiquitin-like protein 7

3

0

High-throughput

0.638

High

326937

RD23B
UV excision repair protein RAD23 homolog B

2

9

High-throughput

0.628

High

326945

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.624

High

326935

ATX3
Ataxin-3

2

5

Small-scale

0.602

High

326927

MPIP1
M-phase inducer phosphatase 1

2

0

High-throughput

0.602

High

326988

FBW1B
F-box/WD repeat-containing protein 11

2

3

Small-scale

0.584

High

326912

ESR1
Estrogen receptor

1

10

High-throughput

0.541

High

326955

TRA2A
Transformer-2 protein homolog alpha

1

0

Small-scale

0.537

High

326978

FEZ1
Fasciculation and elongation protein zeta-1

1

0

Small-scale

0.537

High

326949

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.536

High

326967

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

3

High-throughput

0.536

High

326991

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

326931

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

Small-scale

0.516

High

326981

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

326933

VAV2
Guanine nucleotide exchange factor VAV2

1

1

High-throughput

0.508

High

326924

MK03
Mitogen-activated protein kinase 3

1

4

Small-scale

0.501

High

326936

RD23A
UV excision repair protein RAD23 homolog A

1

10

Small-scale

0.501

High

326950

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

1

Small-scale

0.501

High

326956

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

3

Small-scale

0.501

High

326979

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.501

High

326977

EYA3
Protein phosphatase EYA3

1

0

High-throughput

0.493

High

326962

LRC73
Leucine-rich repeat-containing protein 73

1

3

High-throughput

0.489

High

326983

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.481

High

326911

RASH
GTPase HRas

1

0

Small-scale

0.480

High

128689

MEN1
Menin

1

1

High-throughput

0.479

High

186675

P73
Tumor protein p73

1

7

Small-scale

0.479

High

222602

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

326910

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

326914

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

326916

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.479

High

326919

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

326920

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

326925

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.479

High

326926

CDC27
Cell division cycle protein 27 homolog

1

1

Small-scale

0.479

High

326928

TTK
Dual specificity protein kinase TTK

1

7

Small-scale

0.479

High

326934

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

326944

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

326946

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

326948

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

326951

MYO1E
Unconventional myosin-Ie

1

1

High-throughput

0.479

High

326952

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

326954

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.479

High

326958

SF3B4
Splicing factor 3B subunit 4

1

1

Small-scale

0.479

High

326961

KLH22
Kelch-like protein 22

1

2

Small-scale

0.479

High

326965

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

326968

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.479

High

326969

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

326980

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

326982

P63
Tumor protein 63

1

7

Small-scale

0.479

High

326984

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

326987

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.479

High

326990

FBW1A
F-box/WD repeat-containing protein 1A

1

3

Small-scale

0.479

High

326957

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

326985

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

326986

XPO7
Exportin-7

1

0

High-throughput

0.458

High

169367

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.457

High

326973

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.457

High

326940

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.457

High

326909

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.445

High

326913

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.445

High

326918

GRAB
Granzyme B

1

4

Small-scale

0.445

High

326921

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.445

High

326932

CXCR3
C-X-C chemokine receptor type 3

1

4

High-throughput

0.445

High

326939

ARL4C
ADP-ribosylation factor-like protein 4C

1

2

High-throughput

0.445

High

326943

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.445

High

326976

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

326929

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

326970

STAM1
Signal transducing adapter molecule 1

1

1

Small-scale

0.437

High

326922

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.426

High

326989

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

326917

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

326923

ACKR3
Atypical chemokine receptor 3

1

3

High-throughput

0.407

High

326953

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.407

High

326963

ANR22
Ankyrin repeat domain-containing protein 22

1

3

High-throughput

0.407

High

326972

LRC46
Leucine-rich repeat-containing protein 46

1

1

High-throughput

0.407

High

326947

CNTN2
Contactin-2

1

0

Small-scale

0.292

High

326971

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

Small-scale

0.292

High

326959

OR7A5
Olfactory receptor 7A5

1

0

High-throughput

0.279

Low

326960

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

326992

PCDA8
Protocadherin alpha-8

1

0

High-throughput

0.279

Low

326974

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.261

Low

129940

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

326964

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

326930

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.232

Low

326966

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025