Protein: LSS
Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)

Gene: LSS
Organism: Homo sapiens
Interactions: 71
UniProt ID: P48449

Gene Ontology (top 5):
GO:0000250 - lanosterol synthase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005811 - lipid droplet
GO:0006694 - steroid biosynthetic process
GO:0006695 - cholesterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873407

PNKD
Probable thioesterase PNKD

3

0

High-throughput

0.638

High

873413

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.585

High

325528

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

873408

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.580

High

873415

CIB1
Calcium and integrin-binding protein 1

2

0

High-throughput

0.580

High

873393

NTCP
Hepatic sodium/bile acid cotransporter

2

1

High-throughput

0.553

High

873396

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.553

High

772670

MYH9
Myosin-9

1

0

High-throughput

0.513

High

873382

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

873383

SUMO1
Small ubiquitin-related modifier 1

1

0

High-throughput

0.513

High

873386

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

873401

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.513

High

873418

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.513

High

873425

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

0

High-throughput

0.513

High

403906

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

172568

XPO1
Exportin-1

1

0

High-throughput

0.458

High

241043

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

791173

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

873380

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

873403

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

652472

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

1

High-throughput

0.439

High

421701

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.438

High

484080

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.426

High

873385

DLK1
Protein delta homolog 1

1

0

High-throughput

0.426

High

873391

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

127648

TR10A
Tumor necrosis factor receptor superfamily member 10A

2

0

High-throughput

0.328

High

488206

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.328

High

873389

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

873419

KISHB
Protein kish-B

2

0

High-throughput

0.316

High

873417

GPR35
G-protein coupled receptor 35

1

0

High-throughput

0.282

High

51310

NTM2F
NUT family member 2F

1

0

High-throughput

0.279

Low

207471

DHX15
ATP-dependent RNA helicase DHX15

1

0

High-throughput

0.279

Low

296762

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

346898

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

873381

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.279

Low

873387

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

873392

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.279

Low

873394

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

873397

ZN718
Zinc finger protein 718

1

0

High-throughput

0.279

Low

873398

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

0

High-throughput

0.279

Low

873399

RAB12
Ras-related protein Rab-12

1

0

High-throughput

0.279

Low

873400

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.279

Low

873402

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

873406

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

873410

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

873411

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

873412

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

873414

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

873422

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

873424

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.279

Low

138011

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.249

Low

411557

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

588163

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

633888

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.249

Low

694886

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767660

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

873384

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

873390

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

873405

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

873409

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

873421

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

873423

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

142299

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.232

Low

330073

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

653184

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

873388

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

873395

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

873404

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

873416

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.232

Low

873420

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.232

Low

873426

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025