Protein: KDF1
Keratinocyte differentiation factor 1

Gene: KDF1
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q8NAX2

Gene Ontology (top 5):
GO:0003334 - keratinocyte development
GO:0005737 - cytoplasm
GO:0005938 - cell cortex
GO:0010482 - regulation of epidermal cell division
GO:0010839 - negative regulation of keratinocyte proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

348255

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1022750

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

High-throughput

0.513

High

1254257

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.513

High

1332901

RRAGD
Ras-related GTP-binding protein D

1

0

High-throughput

0.513

High

1332904

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.513

High

167933

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

1

High-throughput

0.479

High

177909

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

1

High-throughput

0.479

High

374770

RASH
GTPase HRas

1

1

High-throughput

0.479

High

375731

RASK
GTPase KRas

1

1

High-throughput

0.479

High

547171

PYC
Pyruvate carboxylase, mitochondrial

1

1

High-throughput

0.479

High

576464

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

High-throughput

0.479

High

610774

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

727886

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.479

High

882036

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.479

High

888191

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

890538

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.479

High

964675

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.479

High

1032506

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

2

High-throughput

0.479

High

1062552

DHX9
ATP-dependent RNA helicase A

1

3

High-throughput

0.479

High

1146738

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.479

High

1146947

PCBP2
Poly(rC)-binding protein 2

1

1

High-throughput

0.479

High

1160210

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.479

High

1250495

RBP10
Ran-binding protein 10

1

1

High-throughput

0.479

High

1271458

DHX30
ATP-dependent RNA helicase DHX30

1

3

High-throughput

0.479

High

1277158

RGPD4
RanBP2-like and GRIP domain-containing protein 4

1

1

High-throughput

0.479

High

1332875

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.479

High

1332877

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

High-throughput

0.479

High

1332878

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.479

High

123774

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.458

High

175125

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

327619

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

348167

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

0

High-throughput

0.458

High

507281

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

556219

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

608157

PYRG1
CTP synthase 1

1

0

High-throughput

0.458

High

612706

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

686276

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

771912

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.458

High

785301

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

810225

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

835709

KPCI
Protein kinase C iota type

1

0

High-throughput

0.458

High

889154

RBM25
RNA-binding protein 25

1

0

High-throughput

0.458

High

898730

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

921957

COPA
Coatomer subunit alpha

1

0

High-throughput

0.458

High

925569

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.458

High

954545

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.458

High

960801

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.458

High

981589

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.458

High

986111

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

997867

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.458

High

1032364

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.458

High

1057809

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.458

High

1066149

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

0

High-throughput

0.458

High

1106616

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1129452

PUM1
Pumilio homolog 1

1

0

High-throughput

0.458

High

1150052

MARE2
Microtubule-associated protein RP/EB family member 2

1

0

High-throughput

0.458

High

1197019

AMOT
Angiomotin

1

0

High-throughput

0.458

High

1277858

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1279201

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1293372

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.458

High

1294706

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.458

High

1332868

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1332869

PAPD5
Terminal nucleotidyltransferase 4B

1

0

High-throughput

0.458

High

1332870

THOC2
THO complex subunit 2

1

0

High-throughput

0.458

High

1332871

CIP2A
Protein CIP2A

1

0

High-throughput

0.458

High

1332876

DDX1
ATP-dependent RNA helicase DDX1

1

0

High-throughput

0.458

High

1332879

RBM33
RNA-binding protein 33

1

0

High-throughput

0.458

High

1332881

RBM14
RNA-binding protein 14

1

0

High-throughput

0.458

High

1332887

ATX2
Ataxin-2

1

0

High-throughput

0.458

High

1332888

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.458

High

1332890

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.458

High

1332900

WDR6
tRNA

1

0

High-throughput

0.458

High

1332902

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.458

High

1332908

RBM27
RNA-binding protein 27

1

0

High-throughput

0.458

High

1332912

LIMD1
LIM domain-containing protein 1

1

0

High-throughput

0.458

High

1332915

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.458

High

1332917

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.458

High

1332919

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

1332920

MYH15
Myosin-15

1

0

High-throughput

0.458

High

586321

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.439

High

207596

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.437

High

424965

ADT2
ADP/ATP translocase 2

1

2

High-throughput

0.437

High

467941

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

2

High-throughput

0.437

High

552314

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.437

High

600336

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.437

High

608905

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

2

High-throughput

0.437

High

655270

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.437

High

756273

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.437

High

846385

MATR3
Matrin-3

1

1

High-throughput

0.437

High

1024408

S25A3
Solute carrier family 25 member 3

1

3

High-throughput

0.437

High

1040167

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

3

High-throughput

0.437

High

1094215

ACACA
Acetyl-CoA carboxylase 1

1

1

High-throughput

0.437

High

1111812

TRA2A
Transformer-2 protein homolog alpha

1

1

High-throughput

0.437

High

1128240

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.437

High

1153642

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

1

High-throughput

0.437

High

1217885

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

1

High-throughput

0.437

High

1272046

ZN771
Zinc finger protein 771

1

2

High-throughput

0.437

High

1310708

PHF6
PHD finger protein 6

1

1

High-throughput

0.437

High

1311809

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.437

High

1312010

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.437

High

1316412

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.437

High

1325214

ZN664
Zinc finger protein 664

1

2

High-throughput

0.437

High

1332892

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.437

High

1332895

ZN768
Zinc finger protein 768

1

1

High-throughput

0.437

High

1332897

YTDC2
3'-5' RNA helicase YTHDC2

1

3

High-throughput

0.437

High

1332909

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.437

High

1332913

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

2

High-throughput

0.437

High

1332916

TTF2
Transcription termination factor 2

1

1

High-throughput

0.437

High

1007957

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.316

High

1044678

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.316

High

1332872

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.316

High

1211176

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.279

Low

1215598

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.279

Low

160554

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.249

Low

175734

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.249

Low

183033

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.249

Low

243681

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

0

High-throughput

0.249

Low

245125

AQR
RNA helicase aquarius

1

0

High-throughput

0.249

Low

251623

CCNT1
Cyclin-T1

1

0

High-throughput

0.249

Low

275696

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.249

Low

280732

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.249

Low

281230

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.249

Low

283911

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

289618

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.249

Low

290959

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.249

Low

321595

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.249

Low

326588

MFN2
Mitofusin-2

1

0

High-throughput

0.249

Low

338509

SC24B
Protein transport protein Sec24B

1

0

High-throughput

0.249

Low

342257

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

417587

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

644528

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.249

Low

651837

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.249

Low

702627

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.249

Low

841217

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.249

Low

873409

LSS
Lanosterol synthase

1

0

High-throughput

0.249

Low

882782

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.249

Low

888641

YLPM1
YLP motif-containing protein 1

1

0

High-throughput

0.249

Low

895604

SERPH
Serpin H1

1

0

High-throughput

0.249

Low

912965

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.249

Low

932912

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.249

Low

1008243

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.249

Low

1034596

AK17A
A-kinase anchor protein 17A

1

0

High-throughput

0.249

Low

1054316

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.249

Low

1058530

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.249

Low

1090466

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.249

Low

1092180

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.249

Low

1097003

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.249

Low

1103276

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

1111510

MTR1L
Melatonin-related receptor

1

0

High-throughput

0.249

Low

1136039

CND2
Condensin complex subunit 2

1

0

High-throughput

0.249

Low

1138401

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

1138859

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

1147960

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.249

Low

1186094

ZN791
Zinc finger protein 791

1

0

High-throughput

0.249

Low

1194224

LARP7
La-related protein 7

1

0

High-throughput

0.249

Low

1203572

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.249

Low

1206727

RRP12
RRP12-like protein

1

0

High-throughput

0.249

Low

1231849

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.249

Low

1241693

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

1248041

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.249

Low

1271736

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1272179

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.249

Low

1275470

TRM1L
tRNA

1

0

High-throughput

0.249

Low

1279831

CCD91
Coiled-coil domain-containing protein 91

1

0

High-throughput

0.249

Low

1289457

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1332873

MCLN3
Mucolipin-3

1

0

High-throughput

0.249

Low

1332874

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.249

Low

1332880

ZCCHL
Zinc finger CCCH-type antiviral protein 1-like

1

0

High-throughput

0.249

Low

1332882

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.249

Low

1332883

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.249

Low

1332884

RBM15
RNA-binding protein 15

1

0

High-throughput

0.249

Low

1332885

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.249

Low

1332886

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.249

Low

1332889

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

1332891

WDR33
pre-mRNA 3' end processing protein WDR33

1

0

High-throughput

0.249

Low

1332893

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.249

Low

1332894

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.249

Low

1332896

NOL6
Nucleolar protein 6

1

0

High-throughput

0.249

Low

1332898

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low

1332899

JPH1
Junctophilin-1

1

0

High-throughput

0.249

Low

1332903

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.249

Low

1332905

ZN701
Zinc finger protein 701

1

0

High-throughput

0.249

Low

1332906

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.249

Low

1332907

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.249

Low

1332910

ZN629
Zinc finger protein 629

1

0

High-throughput

0.249

Low

1332911

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.249

Low

1332914

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.249

Low

1332918

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

1

0

High-throughput

0.249

Low

1332921

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.249

Low

1332922

ZN281
Zinc finger protein 281

1

0

High-throughput

0.249

Low

1332923

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

1332924

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025