Protein: HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)

Gene: HMCS1, HMGCS1
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q01581

Gene Ontology (top 5):
GO:0004421 - hydroxymethylglutaryl-CoA synthase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006084 - acetyl-CoA metabolic process
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1031125

FSD1
Fibronectin type III and SPRY domain-containing protein 1

3

1

High-throughput

0.667

High

787634

SPB5
Serpin B5

3

0

High-throughput

0.638

High

1031103

CD5R1
Cyclin-dependent kinase 5 activator 1

3

0

High-throughput

0.638

High

303228

S22A5
Organic cation/carnitine transporter 2

2

1

High-throughput

0.621

High

1031123

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

241428

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

254357

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.513

High

282576

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.513

High

602774

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

733335

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

873386

LSS
Lanosterol synthase

1

0

High-throughput

0.513

High

943036

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

987335

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

1023753

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1031098

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1031122

IL17F
Interleukin-17F

1

0

High-throughput

0.513

High

1031126

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

1031127

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

1031130

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

1031131

SPNXB
Sperm protein associated with the nucleus on the X chromosome B1

1

0

High-throughput

0.513

High

1031138

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

1031139

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

1031116

PP14C
Protein phosphatase 1 regulatory subunit 14C

1

0

High-throughput

0.493

High

1031110

CERS3
Ceramide synthase 3

1

1

High-throughput

0.489

High

1031113

CERS5
Ceramide synthase 5

1

1

High-throughput

0.489

High

185619

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1031099

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1031100

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1031107

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

Small-scale

0.479

High

1031108

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1031124

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

1031129

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

227505

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

284390

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

370185

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

536992

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

612981

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

1031102

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1031109

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1031112

CUL9
Cullin-9

1

0

Small-scale

0.458

High

1031115

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1031117

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

1031118

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1031120

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1031133

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1031135

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1031137

FBXL7
F-box/LRR-repeat protein 7

1

0

Small-scale

0.458

High

529652

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

934480

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1031106

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

886767

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

248527

O10H3
Olfactory receptor 10H3

3

0

High-throughput

0.347

High

329871

OR5F1
Olfactory receptor 5F1

3

0

High-throughput

0.347

High

659671

NFYA
Nuclear transcription factor Y subunit alpha

3

0

High-throughput

0.347

High

1031134

MBD5
Methyl-CpG-binding domain protein 5

3

0

High-throughput

0.347

High

387820

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

616742

SDC1
Syndecan-1

2

0

High-throughput

0.328

High

325313

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

906872

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.279

Low

943466

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

1031101

INSL4
Early placenta insulin-like peptide

1

0

High-throughput

0.279

Low

1031104

RCN1
Reticulocalbin-1

1

0

High-throughput

0.279

Low

1031105

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1031114

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1031119

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

1031121

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1031132

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1031136

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

418071

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

588489

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695238

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767980

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

878978

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

437662

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

1031097

P
P protein

1

0

High-throughput

0.232

Low

1031111

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

1031128

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025