Protein: ACOT1
Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.-) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2)

Gene: ACOT1
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q86TX2

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0001676 - long-chain fatty acid metabolic process
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006631 - fatty acid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888720

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

2

1

High-throughput

0.811

High

1287622

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.585

High

279822

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

348592

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.584

High

1087442

GRSF1
G-rich sequence factor 1

2

1

High-throughput

0.584

High

560004

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

1287669

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.513

High

483596

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.489

High

61541

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

66230

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

183678

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

281998

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287325

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

296264

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

350917

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

361645

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

401071

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

412183

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

471114

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

519154

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532725

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

786158

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

828837

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

841815

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

851942

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856304

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

882755

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

962222

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

986534

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1015565

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1024093

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1048580

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1058118

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1062825

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

1083659

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1090453

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1117771

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1123338

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1135901

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

7

High-throughput

0.479

High

1142589

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1149591

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1207062

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1234438

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1240297

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

1241309

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.479

High

1270574

COX15
Heme A synthase COX15

1

1

High-throughput

0.479

High

1271437

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1272926

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

7

High-throughput

0.479

High

1287623

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.479

High

1287624

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

3

High-throughput

0.479

High

1287625

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

1287626

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

1287627

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1287628

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

1287630

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

1287631

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1287632

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

1287635

RCC1L
RCC1-like G exchanging factor-like protein

1

1

High-throughput

0.479

High

1287637

IMP1L
Mitochondrial inner membrane protease subunit 1

1

2

High-throughput

0.479

High

1287638

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1287639

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

1287640

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

1287642

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1287643

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1287644

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

1287645

TR61B
tRNA

1

1

High-throughput

0.479

High

1287646

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1287647

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1287648

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1287649

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

1287650

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1287652

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

1287653

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1287654

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1287655

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1287656

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1287659

NGRN
Neugrin

1

1

High-throughput

0.479

High

1287660

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1287661

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

1287662

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

1287663

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

7

High-throughput

0.479

High

1287664

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1287665

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

1287670

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

1287657

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

1

High-throughput

0.470

High

242157

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

801396

HSPA9
Stress-70 protein, mitochondrial

1

0

High-throughput

0.458

High

995670

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1107872

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1162403

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1287629

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.458

High

1287633

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1287634

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1287651

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1287666

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

653413

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

650265

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.437

High

1254450

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

431584

AP2A
Transcription factor AP-2-alpha

3

0

High-throughput

0.345

High

943265

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.282

High

1287636

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

551132

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.279

Low

1157131

KCA10
Potassium voltage-gated channel subfamily A member 10

1

0

High-throughput

0.279

Low

1287641

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.279

Low

1287667

ZF69B
Zinc finger protein 69 homolog B

1

0

High-throughput

0.279

Low

1287668

TM11E
Transmembrane protease serine 11E

1

0

High-throughput

0.279

Low

1287658

HHATL
Protein-cysteine N-palmitoyltransferase HHAT-like protein

1

0

High-throughput

0.269

Low

589049

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695838

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768549

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025