Protein: NT5D2
5'-nucleotidase domain-containing protein 2 (EC 3.1.3.-)

Gene: NT5D2, NT5DC2
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9H857

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0008253 - 5'-nucleotidase activity
GO:0033137 - negative regulation of peptidyl-serine phosphorylation
GO:0045914 - negative regulation of catecholamine metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1289769

NT5D3
5'-nucleotidase domain-containing protein 3

2

6

High-throughput

0.789

High

1234689

ETFR1
Electron transfer flavoprotein regulatory factor 1

3

0

High-throughput

0.638

High

1436166

NT5D2
5'-nucleotidase domain-containing protein 2

1

6

Small-scale

0.618

High

1114320

CUL3
Cullin-3

2

1

High-throughput

0.611

High

1310415

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

242946

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

279918

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

1415674

TR61B
tRNA

2

1

High-throughput

0.571

High

275388

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

1234529

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.536

High

1397658

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

1350985

BRSK1
Serine/threonine-protein kinase BRSK1

1

0

High-throughput

0.513

High

1405614

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

1429844

TOLIP
Toll-interacting protein

1

0

High-throughput

0.513

High

1436171

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1156330

HSPB2
Heat shock protein beta-2

1

2

High-throughput

0.508

High

1436175

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

290738

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.489

High

1431610

IL25
Interleukin-25

1

1

High-throughput

0.489

High

143923

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.479

High

282087

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

412623

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

530383

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

532974

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

652577

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

2

Small-scale

0.479

High

856386

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

955606

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.479

High

1033780

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1083754

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1090922

TRAF2
TNF receptor-associated factor 2

1

1

High-throughput

0.479

High

1093957

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.479

High

1107218

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1117845

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1142669

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1151878

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.479

High

1162557

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1255569

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1270998

RHOU
Rho-related GTP-binding protein RhoU

1

3

High-throughput

0.479

High

1272997

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1367292

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1381727

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1403432

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1436086

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1436168

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

1

Small-scale

0.479

High

1436176

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

66295

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

275106

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

316023

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

320060

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

346341

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

350999

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

363868

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

471255

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

505458

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

519228

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

572219

TRI27
Zinc finger protein RFP

1

0

Small-scale

0.458

High

828962

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841953

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852034

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882890

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

888331

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

1048701

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058278

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1090544

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1140874

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1207145

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1224911

TENS2
Tensin-2

1

0

High-throughput

0.458

High

1271146

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

1383559

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1388411

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1393290

FMC1
Protein FMC1 homolog

1

0

High-throughput

0.458

High

1399849

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1401621

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1412438

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1413020

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

1416547

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1433721

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1433905

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1435293

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1435785

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1436167

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.458

High

1436169

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1436170

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1436173

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1436174

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.458

High

1436177

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

Small-scale

0.458

High

1436179

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1436180

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1209668

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1328674

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.445

High

1436182

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

1407470

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

174614

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

589706

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696524

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

769194

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

971093

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1015794

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

1433511

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.437

High

1436178

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

653572

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

777636

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.426

High

1244591

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1346597

GRPE2
GrpE protein homolog 2, mitochondrial

1

0

High-throughput

0.426

High

1337755

KLDC9
Kelch domain-containing protein 9

2

0

High-throughput

0.328

High

625630

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

867423

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1322357

ZN444
Zinc finger protein 444

1

0

High-throughput

0.279

Low

1436181

EMIL1
EMILIN-1

1

0

High-throughput

0.279

Low

279500

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

342326

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

879467

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1149992

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1276798

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1369578

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

1436172

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025