Protein: SHCAF
SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog)

Gene: SHCAF, SINHCAF
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q9NP50

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0008284 - positive regulation of cell population proliferation
GO:0030336 - negative regulation of cell migration
GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110102

HDAC1
Histone deacetylase 1

7

1

Small-scale

0.750

High

1159014

RBBP7
Histone-binding protein RBBP7

5

1

Small-scale

0.718

High

282315

SAP30
Histone deacetylase complex subunit SAP30

5

1

Small-scale

0.716

High

1066504

RBBP4
Histone-binding protein RBBP4

4

1

Small-scale

0.699

High

1368137

HDAC2
Histone deacetylase 2

4

1

Small-scale

0.699

High

274385

SIN3B
Paired amphipathic helix protein Sin3b

4

1

Small-scale

0.691

High

711794

ARI4A
AT-rich interactive domain-containing protein 4A

4

1

Small-scale

0.691

High

1195603

ARI4B
AT-rich interactive domain-containing protein 4B

4

1

Small-scale

0.691

High

1208647

BRM1L
Breast cancer metastasis-suppressor 1-like protein

4

2

Small-scale

0.691

High

1403027

SIN3A
Paired amphipathic helix protein Sin3a

4

1

Small-scale

0.691

High

1429908

SP130
Histone deacetylase complex subunit SAP130

4

2

Small-scale

0.691

High

1430816

ING2
Inhibitor of growth protein 2

4

3

Small-scale

0.691

High

1437567

SP30L
Histone deacetylase complex subunit SAP30L

4

1

Small-scale

0.691

High

1435858

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

3

2

Small-scale

0.667

High

1439488

BRMS1
Breast cancer metastasis-suppressor 1

3

2

Small-scale

0.667

High

1445814

ING1
Inhibitor of growth protein 1

3

3

Small-scale

0.667

High

1017496

FOXK1
Forkhead box protein K1

3

1

High-throughput

0.662

High

1029765

FOXK2
Forkhead box protein K2

3

1

High-throughput

0.662

High

190169

TNC18
Trinucleotide repeat-containing gene 18 protein

4

2

Small-scale

0.630

High

369508

AACT
Alpha-1-antichymotrypsin

2

2

High-throughput

0.628

High

445070

S10A9
Protein S100-A9

2

2

High-throughput

0.628

High

724635

S10A7
Protein S100-A7

2

2

High-throughput

0.628

High

1163222

H2B2E
Histone H2B type 2-E

2

1

Small-scale

0.611

High

1445810

BAHC1
BAH and coiled-coil domain-containing protein 1

3

2

Small-scale

0.609

High

345215

ZMYM6
Zinc finger MYM-type protein 6

2

0

High-throughput

0.602

High

945103

RAB25
Ras-related protein Rab-25

2

0

High-throughput

0.602

High

1104936

XRCC4
DNA repair protein XRCC4

2

0

High-throughput

0.602

High

1365185

NDRG1
Protein NDRG1

2

0

High-throughput

0.602

High

1413848

DHRS4
Dehydrogenase/reductase SDR family member 4

2

0

High-throughput

0.602

High

1133682

NFIX
Nuclear factor 1 X-type

2

3

High-throughput

0.584

High

1331470

ZFP41
Zinc finger protein 41 homolog

2

0

High-throughput

0.580

High

1307263

TF2LX
Homeobox protein TGIF2LX

2

0

High-throughput

0.576

High

457921

INVO
Involucrin

2

1

High-throughput

0.574

High

874872

SPB4
Serpin B4

2

2

High-throughput

0.574

High

1009729

NGAL
Neutrophil gelatinase-associated lipocalin

2

1

High-throughput

0.574

High

1445809

CALL5
Calmodulin-like protein 5

2

1

High-throughput

0.574

High

980370

H4
Histone H4

2

0

Small-scale

0.559

High

713460

SPB3
Serpin B3

1

2

High-throughput

0.536

High

1381643

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

0

High-throughput

0.518

High

1123131

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

423851

APOD
Apolipoprotein D

1

1

High-throughput

0.489

High

706321

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1141478

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

High-throughput

0.489

High

1101241

NMI
N-myc-interactor

1

0

High-throughput

0.486

High

143278

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

225118

TLX3
T-cell leukemia homeobox protein 3

1

5

High-throughput

0.479

High

248354

HBP1
HMG box-containing protein 1

1

2

High-throughput

0.479

High

373214

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

404445

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

406675

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

425046

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.479

High

474313

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

550478

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

552402

ADT3
ADP/ATP translocase 3

1

2

Small-scale

0.479

High

620602

NUCL
Nucleolin

1

1

Small-scale

0.479

High

662283

PAX7
Paired box protein Pax-7

1

1

High-throughput

0.479

High

685354

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.479

High

725324

TLX1
T-cell leukemia homeobox protein 1

1

3

High-throughput

0.479

High

775915

HNF1B
Hepatocyte nuclear factor 1-beta

1

2

High-throughput

0.479

High

854320

KI67
Proliferation marker protein Ki-67

1

1

Small-scale

0.479

High

944750

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.479

High

990765

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

1032550

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

Small-scale

0.479

High

1033789

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1088040

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1095105

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.479

High

1118686

KLF9
Krueppel-like factor 9

1

3

High-throughput

0.479

High

1129756

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.479

High

1152748

ELF2
ETS-related transcription factor Elf-2

1

1

High-throughput

0.479

High

1280517

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.479

High

1351168

SP7
Transcription factor Sp7

1

3

High-throughput

0.479

High

1401403

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1405642

ELF4
ETS-related transcription factor Elf-4

1

1

High-throughput

0.479

High

1408054

H2B1L
Histone H2B type 1-L

1

1

Small-scale

0.479

High

1416917

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.479

High

1437218

NANOG
Homeobox protein NANOG

1

4

High-throughput

0.479

High

1445808

VSX1
Visual system homeobox 1

1

3

High-throughput

0.479

High

181568

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

281251

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.458

High

542663

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.458

High

581731

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

662504

GATA2
Endothelial transcription factor GATA-2

1

0

High-throughput

0.458

High

675695

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

697666

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

756361

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.458

High

810399

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

834061

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.458

High

895801

LHX2
LIM/homeobox protein Lhx2

1

0

High-throughput

0.458

High

907588

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

Small-scale

0.458

High

953119

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

972025

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

995287

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1008365

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

1052912

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.458

High

1062659

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

1357157

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1380177

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1396097

H2A1H
Histone H2A type 1-H

1

0

Small-scale

0.458

High

1403586

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

1404778

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

1445807

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

Small-scale

0.458

High

1445813

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1445815

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

Small-scale

0.458

High

1361396

BBX
HMG box transcription factor BBX

1

2

High-throughput

0.445

High

302972

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

Small-scale

0.437

High

420708

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.437

High

552082

ADT1
ADP/ATP translocase 1

1

2

Small-scale

0.437

High

598213

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

Small-scale

0.437

High

608941

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

Small-scale

0.437

High

680516

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

1445811

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

1431849

TSYL2
Testis-specific Y-encoded-like protein 2

1

0

High-throughput

0.426

High

609335

SAP3
Ganglioside GM2 activator

2

0

High-throughput

0.328

High

627165

TYPH
Thymidine phosphorylase

2

0

High-throughput

0.328

High

692813

CALL3
Calmodulin-like protein 3

2

0

High-throughput

0.328

High

888564

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.328

High

1154350

CYTM
Cystatin-M

2

0

High-throughput

0.328

High

1445816

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

2

0

High-throughput

0.328

High

464214

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.279

Low

1098678

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1347464

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.251

Low

160629

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.249

Low

220997

XPOT
Exportin-T

1

0

Small-scale

0.249

Low

321358

ERLN2
Erlin-2

1

0

Small-scale

0.249

Low

475007

VIME
Vimentin

1

0

Small-scale

0.249

Low

882905

EFTU
Elongation factor Tu, mitochondrial

1

0

Small-scale

0.249

Low

895081

EMD
Emerin

1

0

Small-scale

0.249

Low

921796

COPB
Coatomer subunit beta

1

0

Small-scale

0.249

Low

1014965

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.249

Low

1063629

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.249

Low

1124057

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.249

Low

1192118

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.249

Low

1365766

GCN1
Stalled ribosome sensor GCN1

1

0

Small-scale

0.249

Low

1433959

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1445805

DDX21
Nucleolar RNA helicase 2

1

0

Small-scale

0.249

Low

1445812

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.249

Low

379139

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low

1445806

RAB6B
Ras-related protein Rab-6B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025