Protein: CO3
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]

Gene: CO3, C3
Organism: Homo sapiens
Interactions: 146
UniProt ID: P01024

Gene Ontology (top 5):
GO:0001798 - positive regulation of type IIa hypersensitivity
GO:0001934 - positive regulation of protein phosphorylation
GO:0001970 - positive regulation of activation of membrane attack complex
GO:0002430 - complement receptor mediated signaling pathway
GO:0004866 - endopeptidase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344624

CFAH
Complement factor H

8

16

Small-scale

0.971

High

344632

MCP
Membrane cofactor protein

5

20

Small-scale

0.924

High

344618

CFAI
Complement factor I

4

1

Small-scale

0.888

High

344638

CR2
Complement receptor type 2

3

18

Small-scale

0.867

High

344697

FHR4
Complement factor H-related protein 4

3

20

Small-scale

0.853

High

341566

CFAB
Complement factor B

3

16

Small-scale

0.845

High

344642

PROP
Properdin

2

2

Small-scale

0.778

High

344639

ITAX
Integrin alpha-X

2

7

Small-scale

0.768

High

344636

CR1
Complement receptor type 1

1

20

Small-scale

0.724

High

126322

MATN2
Matrilin-2

1

3

High-throughput

0.691

High

198331

KLK10
Kallikrein-10

1

8

High-throughput

0.691

High

344727

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

Small-scale

0.690

High

119680

MASP2
Mannan-binding lectin serine protease 2

1

8

Small-scale

0.647

High

344608

CO5
Complement C5

1

3

Small-scale

0.647

High

344649

MASP1
Mannan-binding lectin serine protease 1

1

7

Small-scale

0.647

High

344662

FHR3
Complement factor H-related protein 3

1

20

Small-scale

0.647

High

344663

FHR1
Complement factor H-related protein 1

1

17

Small-scale

0.647

High

344710

FHR5
Complement factor H-related protein 5

1

18

Small-scale

0.647

High

344673

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.628

High

344703

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

239684

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

2

3

High-throughput

0.618

High

344607

CO3
Complement C3

1

3

Small-scale

0.618

High

344623

CATG
Cathepsin G

1

7

Small-scale

0.618

High

344628

ITAM
Integrin alpha-M

1

5

Small-scale

0.618

High

344689

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.609

High

327947

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

4

High-throughput

0.606

High

344670

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

0

High-throughput

0.586

High

344725

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

329212

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.580

High

344672

K1H1
Keratin, type I cuticular Ha1

2

0

High-throughput

0.580

High

344619

F13B
Coagulation factor XIII B chain

1

17

Small-scale

0.575

High

344704

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.574

High

344676

MYOME
Myomegalin

2

3

High-throughput

0.558

High

62262

GG6L9
Golgin subfamily A member 6-like protein 9

2

2

High-throughput

0.553

High

344654

KR108
Keratin-associated protein 10-8

2

2

High-throughput

0.553

High

344627

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.552

High

182996

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.536

High

328078

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

344630

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

344634

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

344637

LEG3
Galectin-3

1

7

High-throughput

0.536

High

344643

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.536

High

344652

STX17
Syntaxin-17

1

4

High-throughput

0.536

High

344675

FNDC1
Fibronectin type III domain-containing protein 1

1

3

High-throughput

0.536

High

344680

CRDL2
Chordin-like protein 2

1

1

High-throughput

0.536

High

344682

GP141
Probable G-protein coupled receptor 141

1

6

High-throughput

0.536

High

344683

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.536

High

344691

FNDC5
Fibronectin type III domain-containing protein 5

1

3

High-throughput

0.536

High

344696

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

344700

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

344707

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.536

High

344709

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

344723

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

2

High-throughput

0.536

High

344616

ITB2
Integrin beta-2

1

2

Small-scale

0.527

High

344650

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.513

High

344669

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

344625

HMGB1
High mobility group protein B1

1

7

High-throughput

0.508

High

344621

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.501

High

344631

CBPN
Carboxypeptidase N catalytic chain

1

2

Small-scale

0.501

High

344668

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.500

High

344622

FUMH
Fumarate hydratase, mitochondrial

1

0

Small-scale

0.493

High

217692

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

303617

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.489

High

309349

MBD4
Methyl-CpG-binding domain protein 4

1

2

High-throughput

0.489

High

344629

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.489

High

344653

DSCR6
Protein ripply3

1

2

High-throughput

0.489

High

344660

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.489

High

344674

CR021
UPF0711 protein C18orf21

1

3

High-throughput

0.489

High

344677

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

344679

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

344684

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

344687

NRSN1
Neurensin-1

1

3

High-throughput

0.489

High

344695

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

344699

PIGT
GPI transamidase component PIG-T

1

3

High-throughput

0.489

High

344701

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.489

High

344706

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

344708

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.489

High

344715

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.489

High

344717

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.489

High

344722

PHF11
PHD finger protein 11

1

5

High-throughput

0.489

High

344729

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.489

High

344640

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.481

High

344686

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.480

High

344610

FINC
Fibronectin

1

4

Small-scale

0.479

High

344612

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

344617

IC1
Plasma protease C1 inhibitor

1

1

High-throughput

0.479

High

344626

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

344635

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

344657

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

344671

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.479

High

344692

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.479

High

344698

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

344702

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.479

High

344718

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

344731

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

129632

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

344094

ANT3
Antithrombin-III

1

0

High-throughput

0.458

High

344611

TRFE
Serotransferrin

1

0

High-throughput

0.458

High

344614

HRG
Histidine-rich glycoprotein

1

0

High-throughput

0.458

High

344620

PERM
Myeloperoxidase

1

0

Small-scale

0.458

High

344645

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

344651

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

344658

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.458

High

344719

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.458

High

344730

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.458

High

344678

A16L1
Autophagy-related protein 16-1

1

1

Small-scale

0.457

High

344664

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

344728

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

226209

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.437

High

260426

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

344615

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

344641

H2B1O
Histone H2B type 1-O

1

3

High-throughput

0.437

High

344646

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.437

High

344647

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.437

High

344655

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

344656

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

344665

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

344666

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.437

High

344681

ASXL2
Putative Polycomb group protein ASXL2

1

4

High-throughput

0.437

High

344685

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.437

High

344711

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

344716

ANLN
Anillin

1

2

High-throughput

0.437

High

344720

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.437

High

344721

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

344609

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

344613

PRIO
Major prion protein

1

0

High-throughput

0.426

High

344661

ANK2
Ankyrin-2

1

0

High-throughput

0.426

High

344667

CUL3
Cullin-3

1

0

High-throughput

0.426

High

344693

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

344688

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.407

High

344690

ASCC1
Activating signal cointegrator 1 complex subunit 1

3

0

High-throughput

0.347

High

344633

ZSC20
Zinc finger and SCAN domain-containing protein 20

2

0

High-throughput

0.328

High

344644

CAH8
Carbonic anhydrase-related protein

2

0

High-throughput

0.328

High

344712

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

344713

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

149516

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.279

Low

344648

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

344659

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.279

Low

344694

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.279

Low

344714

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

344724

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

344726

ING4
Inhibitor of growth protein 4

1

0

High-throughput

0.279

Low

100360

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

224255

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

344705

EYA1
Eyes absent homolog 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024