Protein: CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase)

Gene: CK5P1, CDK5RAP1
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q96SZ6

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0007420 - brain development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1326547

CARME
Carnosine N-methyltransferase

4

0

High-throughput

0.661

High

558350

XRCC6
X-ray repair cross-complementing protein 6

2

1

High-throughput

0.628

High

559465

XRCC5
X-ray repair cross-complementing protein 5

2

1

High-throughput

0.628

High

1216276

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

2

0

High-throughput

0.602

High

1307905

ARMC8
Armadillo repeat-containing protein 8

2

0

High-throughput

0.602

High

1328660

KCD17
BTB/POZ domain-containing protein KCTD17

3

1

High-throughput

0.593

High

1234496

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.585

High

1212233

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

1

High-throughput

0.558

High

457631

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

656021

CAH6
Carbonic anhydrase 6

1

1

High-throughput

0.536

High

896620

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.536

High

1118566

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.536

High

275356

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

278728

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

288252

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

0

High-throughput

0.513

High

690539

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

821520

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.513

High

869216

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

994739

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.513

High

1200496

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.513

High

1242612

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1272730

MAEA
E3 ubiquitin-protein transferase MAEA

1

0

High-throughput

0.513

High

1309363

ARI3B
AT-rich interactive domain-containing protein 3B

1

0

High-throughput

0.513

High

1389178

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1392856

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.513

High

1398171

HEXI2
Protein HEXIM2

1

0

High-throughput

0.513

High

1403194

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.513

High

1403195

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.513

High

1403210

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1403211

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1403213

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1057111

FMOD
Fibromodulin

1

2

High-throughput

0.489

High

1295420

RAB43
Ras-related protein Rab-43

1

1

High-throughput

0.489

High

1310196

SFPA2
Pulmonary surfactant-associated protein A2

1

1

High-throughput

0.489

High

1356085

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

1

High-throughput

0.489

High

1395159

HIPL1
HHIP-like protein 1

1

1

High-throughput

0.489

High

1403212

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.489

High

1403203

EXOS5
Exosome complex component RRP46

1

0

High-throughput

0.486

High

1403204

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.486

High

1142259

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

Small-scale

0.480

High

696291

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

768965

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

856351

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

1015702

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.479

High

1106052

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.479

High

1114085

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1162507

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1310333

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

1403197

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1403198

MTRFR
Mitochondrial translation release factor in rescue

1

1

High-throughput

0.479

High

1403200

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1403208

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1403209

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

132247

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

Small-scale

0.458

High

183712

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

279872

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

282050

MPPB
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.458

High

347882

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

350963

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

471198

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

473002

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

519203

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

589481

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

851997

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

1048653

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058223

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1117813

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1123387

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1178324

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1207110

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1368073

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1381681

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1383543

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1386545

OPTN
Optineurin

1

0

High-throughput

0.458

High

1388244

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1388373

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1400800

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1401584

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1403196

TR61B
tRNA

1

0

High-throughput

0.458

High

1403202

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1403205

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1403207

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1403214

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

844857

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

944040

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1255181

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1327144

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1403199

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

1403201

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

191385

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.426

High

1395383

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

1403206

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.426

High

71065

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

1

High-throughput

0.407

High

192126

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.328

High

846432

MATR3
Matrin-3

2

0

High-throughput

0.328

High

1233891

K0930
Uncharacterized protein KIAA0930

2

0

High-throughput

0.328

High

1388486

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.328

High

1403215

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.313

High

207867

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

933215

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1213684

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1220488

F219B
Protein FAM219B

1

0

High-throughput

0.279

Low

1349096

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1384941

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025