Protein: PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)

Gene: PDXD1, PDXDC1
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q6P996

Gene Ontology (top 5):
GO:0005794 - Golgi apparatus
GO:0016831 - carboxy-lyase activity
GO:0019752 - carboxylic acid metabolic process
GO:0030170 - pyridoxal phosphate binding
GO:0043231 - intracellular membrane-bounded organelle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

562150

LAMP2
Lysosome-associated membrane glycoprotein 2

3

2

High-throughput

0.667

High

851069

LPAR6
Lysophosphatidic acid receptor 6

3

5

High-throughput

0.667

High

631297

RAB5A
Ras-related protein Rab-5A

3

1

High-throughput

0.633

High

754050

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.618

High

1242139

PDXD2
Putative pyridoxal-dependent decarboxylase domain-containing protein 2

1

9

High-throughput

0.618

High

1243232

CD244
Natural killer cell receptor 2B4

3

2

High-throughput

0.609

High

1243254

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

2

0

High-throughput

0.585

High

374002

RASN
GTPase NRas

2

5

High-throughput

0.584

High

710311

EPHA2
Ephrin type-A receptor 2

2

2

High-throughput

0.584

High

976348

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.584

High

1243259

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.578

High

665317

EDNRB
Endothelin receptor type B

2

3

High-throughput

0.574

High

669012

FPR2
N-formyl peptide receptor 2

2

7

High-throughput

0.574

High

771154

APJ
Apelin receptor

2

4

High-throughput

0.574

High

845516

PI2R
Prostacyclin receptor

2

2

High-throughput

0.574

High

1243207

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

1

High-throughput

0.574

High

1243253

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

8

High-throughput

0.574

High

675061

TNR6
Tumor necrosis factor receptor superfamily member 6

2

1

High-throughput

0.558

High

1187468

AR13B
ADP-ribosylation factor-like protein 13B

2

5

High-throughput

0.558

High

719798

V2R
Vasopressin V2 receptor

1

2

High-throughput

0.536

High

1053015

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.536

High

1243204

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

1

High-throughput

0.536

High

540510

LAMP1
Lysosome-associated membrane glycoprotein 1

2

2

High-throughput

0.533

High

845686

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.517

High

1004096

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.517

High

1126268

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

1

0

High-throughput

0.513

High

1243248

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

1243252

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

167615

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.493

High

390623

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

133268

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.489

High

165963

FFAR1
Free fatty acid receptor 1

1

6

High-throughput

0.489

High

182600

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.489

High

538622

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.489

High

638450

FPR1
fMet-Leu-Phe receptor

1

7

High-throughput

0.489

High

832419

OPRX
Nociceptin receptor

1

2

High-throughput

0.489

High

854543

S15A1
Solute carrier family 15 member 1

1

1

High-throughput

0.489

High

880158

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

886286

ARL4D
ADP-ribosylation factor-like protein 4D

1

6

High-throughput

0.489

High

926787

VMAT1
Chromaffin granule amine transporter

1

3

High-throughput

0.489

High

956911

CXCR4
C-X-C chemokine receptor type 4

1

5

High-throughput

0.489

High

1041761

PPARD
Peroxisome proliferator-activated receptor delta

1

1

High-throughput

0.489

High

1042756

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

2

High-throughput

0.489

High

1101537

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.489

High

1243205

GP150
Probable G-protein coupled receptor 150

1

3

High-throughput

0.489

High

1243218

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

High-throughput

0.489

High

1243226

CML1
Chemerin-like receptor 1

1

8

High-throughput

0.489

High

1243234

DNAI2
Dynein axonemal intermediate chain 2

1

1

High-throughput

0.489

High

1243243

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

2

High-throughput

0.489

High

1243257

TRI35
E3 ubiquitin-protein ligase TRIM35

1

1

High-throughput

0.489

High

1243266

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

226086

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

363434

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

484166

PGFRB
Platelet-derived growth factor receptor beta

1

6

High-throughput

0.479

High

556162

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

560427

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

593397

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.479

High

604044

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630549

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.479

High

641199

FGFR2
Fibroblast growth factor receptor 2

1

9

High-throughput

0.479

High

648560

FGFR4
Fibroblast growth factor receptor 4

1

10

High-throughput

0.479

High

827207

ARL1
ADP-ribosylation factor-like protein 1

1

4

High-throughput

0.479

High

901323

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.479

High

945023

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.479

High

956348

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

1015047

ARF5
ADP-ribosylation factor 5

1

3

High-throughput

0.479

High

1063352

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.479

High

1243260

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

218336

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

327321

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

731402

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

894832

EMD
Emerin

1

0

High-throughput

0.458

High

934754

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

1041127

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1178206

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1243202

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

1243203

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1243212

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.458

High

1243220

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1243222

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1243228

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.458

High

1243255

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

126659

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.437

High

179939

BET1
BET1 homolog

1

1

High-throughput

0.437

High

189645

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

375630

RASK
GTPase KRas

1

5

High-throughput

0.437

High

412109

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

463987

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

9

High-throughput

0.437

High

541554

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.437

High

581121

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.437

High

612253

ARF4
ADP-ribosylation factor 4

1

3

High-throughput

0.437

High

630848

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.437

High

897313

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.437

High

901884

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.437

High

910102

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.437

High

931861

EPHA5
Ephrin type-A receptor 5

1

3

High-throughput

0.437

High

953513

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.437

High

955303

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.437

High

958129

ARP3
Actin-related protein 3

1

1

High-throughput

0.437

High

958783

ARF3
ADP-ribosylation factor 3

1

3

High-throughput

0.437

High

962175

RHOA
Transforming protein RhoA

1

5

High-throughput

0.437

High

962771

RND3
Rho-related GTP-binding protein RhoE

1

7

High-throughput

0.437

High

1014911

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.437

High

1015533

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.437

High

1031421

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1062986

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

High-throughput

0.437

High

1087155

STX4
Syntaxin-4

1

1

High-throughput

0.437

High

1144967

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.437

High

1147351

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.437

High

1156975

NTRK3
NT-3 growth factor receptor

1

8

High-throughput

0.437

High

1159506

NTRK2
BDNF/NT-3 growth factors receptor

1

9

High-throughput

0.437

High

1235289

STYK1
Tyrosine-protein kinase STYK1

1

10

High-throughput

0.437

High

1243197

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.437

High

1243199

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1243237

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1243240

RHOF
Rho-related GTP-binding protein RhoF

1

6

High-throughput

0.437

High

1243241

SAR1A
Small COPII coat GTPase SAR1A

1

6

High-throughput

0.437

High

1243263

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

2

High-throughput

0.437

High

1243267

ARL5A
ADP-ribosylation factor-like protein 5A

1

5

High-throughput

0.437

High

1243268

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.437

High

231592

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.407

High

652203

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

2

High-throughput

0.407

High

1157176

S15A2
Solute carrier family 15 member 2

1

1

High-throughput

0.407

High

1226895

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1243214

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

1243217

S67A1
Solute carrier family 67 member A1

1

4

High-throughput

0.407

High

1243221

PCFT
Proton-coupled folate transporter

1

4

High-throughput

0.407

High

1243235

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

1

High-throughput

0.407

High

216721

HTRA2
Serine protease HTRA2, mitochondrial

1

1

Small-scale

0.373

High

466918

ACM4
Muscarinic acetylcholine receptor M4

2

0

High-throughput

0.328

High

702792

5HT2C
5-hydroxytryptamine receptor 2C

2

0

High-throughput

0.328

High

749217

CD70
CD70 antigen

2

0

High-throughput

0.328

High

1196197

S22A6
Solute carrier family 22 member 6

2

0

High-throughput

0.328

High

1200480

H1BP3
HCLS1-binding protein 3

2

0

High-throughput

0.328

High

1243192

TM108
Transmembrane protein 108

2

0

High-throughput

0.328

High

1243206

F174A
Membrane protein FAM174A

2

0

High-throughput

0.328

High

1243245

S39A9
Zinc transporter ZIP9

2

0

High-throughput

0.328

High

1243256

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

2

0

High-throughput

0.318

High

1243201

MFD4A
Major facilitator superfamily domain-containing protein 4A

2

0

High-throughput

0.313

High

158453

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.279

Low

230704

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

298190

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

549619

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

563927

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.279

Low

636863

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.279

Low

1022881

EFNB1
Ephrin-B1

1

0

High-throughput

0.279

Low

1064384

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

0

High-throughput

0.279

Low

1151475

IKBB
NF-kappa-B inhibitor beta

1

0

High-throughput

0.279

Low

1176994

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1180645

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.279

Low

1242333

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1243193

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1243194

SO4C1
Solute carrier organic anion transporter family member 4C1

1

0

High-throughput

0.279

Low

1243196

RIP
RPA-interacting protein

1

0

High-throughput

0.279

Low

1243208

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1243211

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1243213

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

1243215

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

1243216

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

1243219

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

1243225

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1243227

KCD14
BTB/POZ domain-containing protein KCTD14

1

0

High-throughput

0.279

Low

1243231

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1243238

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1243247

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.279

Low

1243261

SC5A6
Sodium-dependent multivitamin transporter

1

0

High-throughput

0.279

Low

1243264

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.279

Low

1243224

PHB2
Prohibitin-2

1

0

High-throughput

0.269

Low

1243265

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.269

Low

139903

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

277368

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.249

Low

291393

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

293870

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

353396

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

693005

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.249

Low

715636

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

768459

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

965031

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

986503

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.249

Low

1106584

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

1140435

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1159700

OCLN
Occludin

1

0

High-throughput

0.249

Low

1229532

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1233286

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1243191

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1243195

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1243198

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1243200

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1243210

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

1243223

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

1243229

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.249

Low

1243230

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.249

Low

1243236

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1243239

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1243242

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.249

Low

1243244

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.249

Low

1243246

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1243249

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1243250

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1243251

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1243262

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.249

Low

1243209

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.232

Low

1243233

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

1243258

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025