Protein: FACE1
CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog)

Gene: FACE1, ZMPSTE24
Organism: Homo sapiens
Interactions: 136
UniProt ID: O75844

Gene Ontology (top 5):
GO:0001889 - liver development
GO:0001942 - hair follicle development
GO:0003007 - heart morphogenesis
GO:0003229 - ventricular cardiac muscle tissue development
GO:0003231 - cardiac ventricle development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

295785

CP1A1
Cytochrome P450 1A1

3

1

High-throughput

0.667

High

295874

RNF26
E3 ubiquitin-protein ligase RNF26

3

0

High-throughput

0.638

High

295857

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

0

High-throughput

0.634

High

295810

VMAT1
Chromaffin granule amine transporter

2

1

High-throughput

0.628

High

295817

VAC14
Protein VAC14 homolog

2

1

High-throughput

0.628

High

295794

FPPS
Farnesyl pyrophosphate synthase

2

0

High-throughput

0.602

High

295816

TNR17
Tumor necrosis factor receptor superfamily member 17

2

0

High-throughput

0.602

High

295774

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.586

High

295815

IFM3
Interferon-induced transmembrane protein 3

2

0

Small-scale

0.585

High

295849

NRM
Nurim

2

0

High-throughput

0.576

High

295811

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

295777

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.536

High

295796

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.536

High

295889

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.536

High

295781

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.527

High

295800

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.515

High

129932

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

142124

NPT3
Sodium-dependent phosphate transport protein 3

1

0

High-throughput

0.513

High

227737

MYO1B
Unconventional myosin-Ib

1

0

High-throughput

0.513

High

295782

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.513

High

295789

NEP
Neprilysin

1

0

Small-scale

0.513

High

295798

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

295801

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.513

High

295803

CALX
Calnexin

1

0

High-throughput

0.513

High

295806

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

295812

FGF12
Fibroblast growth factor 12

1

0

High-throughput

0.513

High

295814

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

295822

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

295827

ADCK5
Uncharacterized aarF domain-containing protein kinase 5

1

0

High-throughput

0.513

High

295829

TM196
Transmembrane protein 196

1

0

High-throughput

0.513

High

295833

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

295843

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.513

High

295862

PDLI5
PDZ and LIM domain protein 5

1

0

High-throughput

0.513

High

295866

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

0

High-throughput

0.513

High

295870

ABHEA
Protein ABHD14A

1

0

High-throughput

0.513

High

295890

COPZ2
Coatomer subunit zeta-2

1

0

High-throughput

0.513

High

295897

PRLD1
PRELI domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

295898

WASC3
WASH complex subunit 3

1

0

High-throughput

0.513

High

295797

H15
Histone H1.5

1

0

High-throughput

0.493

High

295876

O51V1
Olfactory receptor 51V1

1

0

High-throughput

0.493

High

295838

CXB7
Gap junction beta-7 protein

1

1

High-throughput

0.489

High

295791

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

295818

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

295846

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

295852

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

295854

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

173798

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

240311

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

295778

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

295783

GCR
Glucocorticoid receptor

1

0

Small-scale

0.458

High

295784

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

295786

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

295787

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

295802

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

295805

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

295808

EMD
Emerin

1

0

High-throughput

0.458

High

295809

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

295821

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

295830

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

295839

SCIMP
SLP adapter and CSK-interacting membrane protein

1

0

High-throughput

0.458

High

295840

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

295842

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

295848

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

295855

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

295856

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

295858

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

295859

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

295865

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

295875

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

295877

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

295882

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

295885

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

295888

CHMP5
Charged multivesicular body protein 5

1

0

High-throughput

0.458

High

295892

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

295832

MF14B
Hippocampus abundant transcript-like protein 1

1

2

High-throughput

0.445

High

295863

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.445

High

295873

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

295887

SCN3B
Sodium channel regulatory subunit beta-3

1

1

High-throughput

0.445

High

295795

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

295836

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

295850

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

295861

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

295775

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

295823

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

295831

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

295835

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

142254

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.407

High

295819

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.328

High

295867

GPR21
Probable G-protein coupled receptor 21

2

0

High-throughput

0.328

High

295896

STX8
Syntaxin-8

2

0

High-throughput

0.328

High

184535

DFB4A
Defensin beta 4A

2

0

High-throughput

0.319

High

295891

MARH4
E3 ubiquitin-protein ligase MARCHF4

2

0

High-throughput

0.318

High

295837

PMF1
Polyamine-modulated factor 1

2

0

High-throughput

0.305

High

212751

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

0

High-throughput

0.279

Low

295780

DNAL4
Dynein axonemal light chain 4

1

0

High-throughput

0.279

Low

295792

IL7
Interleukin-7

1

0

High-throughput

0.279

Low

295799

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

295804

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.279

Low

295825

KRA61
Keratin-associated protein 6-1

1

0

High-throughput

0.279

Low

295826

KR194
Keratin-associated protein 19-4

1

0

High-throughput

0.279

Low

295828

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.279

Low

295844

TMPSC
Transmembrane protease serine 12

1

0

High-throughput

0.279

Low

295847

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.279

Low

295851

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

295860

OPTN
Optineurin

1

0

High-throughput

0.279

Low

295864

TECTB
Beta-tectorin

1

0

High-throughput

0.279

Low

295868

F118B
Protein FAM118B

1

0

High-throughput

0.279

Low

295869

S39A3
Zinc transporter ZIP3

1

0

High-throughput

0.279

Low

295871

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.279

Low

295878

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

295880

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

295881

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

295883

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

295893

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

295899

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

295807

CDX1
Homeobox protein CDX-1

1

0

High-throughput

0.269

Low

295895

IL19
Interleukin-19

1

0

High-throughput

0.269

Low

295872

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

62238

SMIP7
Protein SPMIP7

1

0

High-throughput

0.249

Low

217623

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

295779

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

295788

ISG15
Ubiquitin-like protein ISG15

1

0

High-throughput

0.249

Low

295790

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

295793

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

295813

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

295820

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

295834

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

295841

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

295853

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

295879

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

295886

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

295894

TRM7
tRNA

1

0

High-throughput

0.249

Low

295776

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

295824

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

295845

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

295884

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025