Protein: CX6B1
Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)

Gene: CX6B1, COX6B1
Organism: Homo sapiens
Interactions: 103
UniProt ID: P14854

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen
GO:0021762 - substantia nigra development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551651

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

2

1

High-throughput

0.789

High

576082

CX6B1
Cytochrome c oxidase subunit 6B1

2

1

High-throughput

0.737

High

348343

AIFM1
Apoptosis-inducing factor 1, mitochondrial

4

1

High-throughput

0.687

High

576083

QCR7
Cytochrome b-c1 complex subunit 7

4

1

High-throughput

0.683

High

572343

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

3

2

High-throughput

0.667

High

559857

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

High-throughput

0.656

High

576121

MIA40
Mitochondrial intermembrane space import and assembly protein 40

3

2

High-throughput

0.650

High

137638

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.618

High

168962

QCR8
Cytochrome b-c1 complex subunit 8

2

0

High-throughput

0.602

High

528415

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

1

High-throughput

0.601

High

576139

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

576086

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

2

High-throughput

0.536

High

576087

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

2

High-throughput

0.536

High

576097

SUOX
Sulfite oxidase, mitochondrial

1

1

High-throughput

0.536

High

576130

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

1

High-throughput

0.536

High

528995

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

557059

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

576085

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.513

High

576126

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

0

High-throughput

0.513

High

576141

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.513

High

576147

QCR9
Cytochrome b-c1 complex subunit 9

1

0

High-throughput

0.513

High

156186

CO72L
Cytochrome c oxidase subunit 7A2-like, mitochondrial

1

2

High-throughput

0.479

High

576094

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.479

High

576132

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

576136

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.479

High

576137

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

209738

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.458

High

245414

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

278619

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.458

High

292068

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

296190

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

328494

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.458

High

333549

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.458

High

333620

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.458

High

343305

SNP29
Synaptosomal-associated protein 29

1

0

High-throughput

0.458

High

485834

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.458

High

576089

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.458

High

576095

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

576098

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

High-throughput

0.458

High

576104

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

576107

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

576108

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

576129

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

576133

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

576138

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

576140

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

576142

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

576144

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

339643

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.457

High

576134

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

371065

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

405752

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

576099

KLF3
Krueppel-like factor 3

1

2

High-throughput

0.437

High

576127

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

1

High-throughput

0.437

High

462756

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.426

High

576101

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.407

High

576124

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

278473

VAMP4
Vesicle-associated membrane protein 4

2

0

High-throughput

0.328

High

576114

TM220
Transmembrane protein 220

2

0

High-throughput

0.328

High

576091

GRN
Progranulin

2

0

High-throughput

0.318

High

395424

ESR1
Estrogen receptor

2

0

High-throughput

0.298

High

576106

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.298

High

576110

H37
Histone H3-7

2

0

High-throughput

0.288

High

165898

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

270617

ATP9A
Probable phospholipid-transporting ATPase IIA

1

0

High-throughput

0.279

Low

281713

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.279

Low

340289

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.279

Low

407572

S100B
Protein S100-B

1

0

High-throughput

0.279

Low

559202

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.279

Low

576096

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

576100

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.279

Low

576102

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

576103

CAV1
Caveolin-1

1

0

High-throughput

0.279

Low

576109

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

576111

STUM
Protein stum homolog

1

0

High-throughput

0.279

Low

576115

DYM
Dymeclin

1

0

High-throughput

0.279

Low

576120

SYS1
Protein SYS1 homolog

1

0

High-throughput

0.279

Low

576128

YIPF5
Protein YIPF5

1

0

High-throughput

0.279

Low

576131

CASD1
N-acetylneuraminate

1

0

High-throughput

0.279

Low

576145

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

105252

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

576084

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

576088

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

576092

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

576117

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.249

Low

576118

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

576119

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

576122

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

576135

NUF2
Kinetochore protein Nuf2

1

0

High-throughput

0.249

Low

576148

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

404652

PRIO
Major prion protein

1

0

High-throughput

0.232

Low

576090

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

576093

HD
Huntingtin

1

0

High-throughput

0.232

Low

576105

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

576112

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

576113

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

576116

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

576123

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.232

Low

576125

NEK9
Serine/threonine-protein kinase Nek9

1

0

High-throughput

0.232

Low

576143

CNBP1
Beta-catenin-interacting protein 1

1

0

High-throughput

0.232

Low

576146

CT2NL
CTTNBP2 N-terminal-like protein

1

0

High-throughput

0.232

Low

576149

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025