Protein: KLF5
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)

Gene: KLF5
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q13887

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

835739

GSK3B
Glycogen synthase kinase-3 beta

2

8

Small-scale

0.812

High

1046730

FBXW7
F-box/WD repeat-containing protein 7

6

12

Small-scale

0.735

High

998688

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.709

High

487967

RARA
Retinoic acid receptor alpha

4

20

Small-scale

0.692

High

835366

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.691

High

1046753

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

8

10

Small-scale

0.687

High

1024289

ZBT17
Zinc finger and BTB domain-containing protein 17

1

19

Small-scale

0.665

High

157901

KLF11
Krueppel-like factor 11

1

19

High-throughput

0.665

High

566384

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.647

High

1046727

CBP
CREB-binding protein

3

20

Small-scale

0.647

High

880250

MAZ
Myc-associated zinc finger protein

1

16

High-throughput

0.646

High

1046760

SMUF2
E3 ubiquitin-protein ligase SMURF2

2

10

Small-scale

0.643

High

1046720

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

4

Small-scale

0.634

High

1046683

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

2

20

Small-scale

0.624

High

261504

NCOR1
Nuclear receptor corepressor 1

2

20

Small-scale

0.620

High

1046778

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.620

High

550386

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.618

High

575430

EGR1
Early growth response protein 1

1

18

Small-scale

0.618

High

1046774

ZN148
Zinc finger protein 148

1

20

High-throughput

0.618

High

1046775

ZN281
Zinc finger protein 281

1

18

High-throughput

0.618

High

1046690

SMAD2
Mothers against decapentaplegic homolog 2

2

11

Small-scale

0.601

High

868481

ATX1
Ataxin-1

2

9

High-throughput

0.601

High

587571

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

12

Small-scale

0.584

High

808592

YAP1
Transcriptional coactivator YAP1

2

17

Small-scale

0.584

High

831306

CEBPA
CCAAT/enhancer-binding protein alpha

2

15

Small-scale

0.584

High

980748

TLE3
Transducin-like enhancer protein 3

2

17

High-throughput

0.584

High

369571

ESR1
Estrogen receptor

1

20

Small-scale

0.561

High

455418

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.561

High

587168

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.561

High

963809

SET
Protein SET

1

6

Small-scale

0.561

High

1038360

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.561

High

1046722

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

4

Small-scale

0.561

High

1046723

ESR2
Estrogen receptor beta

1

20

Small-scale

0.561

High

569706

CEBPB
CCAAT/enhancer-binding protein beta

1

15

Small-scale

0.552

High

740522

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.552

High

862906

CEBPG
CCAAT/enhancer-binding protein gamma

1

20

Small-scale

0.552

High

1046738

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

10

High-throughput

0.536

High

1046759

ARP5
Actin-related protein 5

1

10

High-throughput

0.536

High

1046771

AKP8L
A-kinase anchor protein 8-like

1

8

High-throughput

0.536

High

1046777

PUS1
Pseudouridylate synthase 1 homolog

1

1

High-throughput

0.536

High

1035427

SMAD4
Mothers against decapentaplegic homolog 4

1

11

Small-scale

0.534

High

1046756

ATX3L
Ataxin-3-like protein

1

1

Small-scale

0.528

High

475737

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.515

High

950175

SMAD3
Mothers against decapentaplegic homolog 3

1

11

Small-scale

0.515

High

258017

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.515

High

803526

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.515

High

1046731

COQA1
Collagen alpha-1(XXVI) chain

1

8

High-throughput

0.515

High

1046767

CTNL1
Alpha-catulin

1

1

Small-scale

0.504

High

401976

JUN
Transcription factor Jun

1

12

Small-scale

0.501

High

589857

TBP
TATA-box-binding protein

1

2

Small-scale

0.501

High

808124

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

930206

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.501

High

959928

TF2B
Transcription initiation factor IIB

1

3

Small-scale

0.501

High

156286

PSA7
Proteasome subunit alpha type-7

1

14

High-throughput

0.500

High

444160

RS17
Small ribosomal subunit protein eS17

1

3

High-throughput

0.500

High

542316

PLAK
Junction plakoglobin

1

12

High-throughput

0.500

High

637682

PSA2
Proteasome subunit alpha type-2

1

17

High-throughput

0.500

High

718842

PHB1
Prohibitin 1

1

6

High-throughput

0.500

High

807151

RS5
Small ribosomal subunit protein uS7

1

10

High-throughput

0.500

High

820916

PRC2A
Protein PRRC2A

1

20

High-throughput

0.500

High

832099

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.500

High

900153

RL37A
Large ribosomal subunit protein eL43

1

4

High-throughput

0.500

High

911378

RS11
Small ribosomal subunit protein uS17

1

6

High-throughput

0.500

High

919967

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.500

High

942158

GTF2I
General transcription factor II-I

1

5

High-throughput

0.500

High

1019490

ILF2
Interleukin enhancer-binding factor 2

1

8

High-throughput

0.500

High

1046712

CCAR2
Cell cycle and apoptosis regulator protein 2

1

6

High-throughput

0.500

High

1046752

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.500

High

658058

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.493

High

879393

FCGRN
IgG receptor FcRn large subunit p51

1

1

High-throughput

0.489

High

534105

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.480

High

664079

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.480

High

1046748

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.479

High

131721

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

146218

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

152643

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

153666

ANM5
Protein arginine N-methyltransferase 5

1

4

Small-scale

0.479

High

162725

XPO1
Exportin-1

1

4

High-throughput

0.479

High

164226

ZN609
Zinc finger protein 609

1

15

High-throughput

0.479

High

170360

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

174875

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

Small-scale

0.479

High

183114

KDM6A
Lysine-specific demethylase 6A

1

12

High-throughput

0.479

High

244416

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

346741

MYC
Myc proto-oncogene protein

1

20

Small-scale

0.479

High

386706

P53
Cellular tumor antigen p53

1

10

Small-scale

0.479

High

473511

ATX1L
Ataxin-1-like

1

9

High-throughput

0.479

High

487416

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

500789

CLUS
Clusterin

1

1

Small-scale

0.479

High

525312

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

585661

TFE3
Transcription factor E3

1

12

High-throughput

0.479

High

717069

CTNB1
Catenin beta-1

1

12

Small-scale

0.479

High

738967

SRBP1
Sterol regulatory element-binding protein 1

1

20

Small-scale

0.479

High

789445

RBM34
RNA-binding protein 34

1

12

High-throughput

0.479

High

839861

CSRP3
Cysteine and glycine-rich protein 3

1

7

Small-scale

0.479

High

846771

SMCA2
Probable global transcription activator SNF2L2

1

20

High-throughput

0.479

High

848215

HCFC1
Host cell factor 1

1

3

Small-scale

0.479

High

876566

AF10
Protein AF-10

1

2

High-throughput

0.479

High

882910

RBM11
Splicing regulator RBM11

1

6

High-throughput

0.479

High

890658

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

917244

H4
Histone H4

1

7

High-throughput

0.479

High

928092

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

952810

FOXK1
Forkhead box protein K1

1

16

High-throughput

0.479

High

980601

TLE1
Transducin-like enhancer protein 1

1

18

High-throughput

0.479

High

993418

TLE5
TLE family member 5

1

12

High-throughput

0.479

High

1018221

NFIA
Nuclear factor 1 A-type

1

17

High-throughput

0.479

High

1040792

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.479

High

1046684

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.479

High

1046686

MEF2D
Myocyte-specific enhancer factor 2D

1

6

High-throughput

0.479

High

1046687

RBBP5
Retinoblastoma-binding protein 5

1

11

High-throughput

0.479

High

1046688

SSXT
Protein SSXT

1

14

High-throughput

0.479

High

1046689

NCOA2
Nuclear receptor coactivator 2

1

14

High-throughput

0.479

High

1046692

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

1046693

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

1046698

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1046699

NIPBL
Nipped-B-like protein

1

17

High-throughput

0.479

High

1046700

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.479

High

1046702

BCOR
BCL-6 corepressor

1

17

High-throughput

0.479

High

1046703

PAXI1
PAX-interacting protein 1

1

8

High-throughput

0.479

High

1046706

LDB1
LIM domain-binding protein 1

1

1

High-throughput

0.479

High

1046707

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

1046709

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

1046710

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

1046711

MGAP
MAX gene-associated protein

1

11

High-throughput

0.479

High

1046713

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.479

High

1046715

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

1046716

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

1046717

KDM2B
Lysine-specific demethylase 2B

1

10

High-throughput

0.479

High

1046718

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

1046719

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1046721

MAML1
Mastermind-like protein 1

1

14

High-throughput

0.479

High

1046724

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.479

High

1046725

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

1046726

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1046728

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

11

High-throughput

0.479

High

1046729

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

11

High-throughput

0.479

High

1046732

ZBT10
Zinc finger and BTB domain-containing protein 10

1

19

High-throughput

0.479

High

1046733

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

5

High-throughput

0.479

High

1046735

FUBP3
Far upstream element-binding protein 3

1

11

High-throughput

0.479

High

1046736

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

19

High-throughput

0.479

High

1046737

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

1046740

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

1046742

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1046743

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1046744

MEP50
Methylosome protein WDR77

1

14

Small-scale

0.479

High

1046745

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

2

High-throughput

0.479

High

1046746

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

1046749

GTPB4
GTP-binding protein 4

1

7

High-throughput

0.479

High

1046751

WWTR1
WW domain-containing transcription regulator protein 1

1

20

Small-scale

0.479

High

1046754

EPC1
Enhancer of polycomb homolog 1

1

10

High-throughput

0.479

High

1046755

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

1046757

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1046762

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

1046763

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

1046766

NOP53
Ribosome biogenesis protein NOP53

1

7

High-throughput

0.479

High

1046768

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

1046769

ZN608
Zinc finger protein 608

1

7

High-throughput

0.479

High

1046776

NOP16
Nucleolar protein 16

1

6

High-throughput

0.479

High

1046779

RT18B
Small ribosomal subunit protein mS40

1

5

High-throughput

0.479

High

1046780

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

Small-scale

0.479

High

1046781

NCOA3
Nuclear receptor coactivator 3

1

14

High-throughput

0.479

High

1046782

ZHX2
Zinc fingers and homeoboxes protein 2

1

20

High-throughput

0.479

High

790931

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

5

Small-scale

0.470

High

151304

IDLC
Axonemal dynein light intermediate polypeptide 1

1

1

High-throughput

0.470

High

1046747

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.470

High

1046772

ICAM5
Intercellular adhesion molecule 5

1

2

High-throughput

0.470

High

172438

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.458

High

1046758

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

596275

FILA
Filaggrin

1

11

High-throughput

0.457

High

1030226

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.457

High

1046694

FILA2
Filaggrin-2

1

16

High-throughput

0.457

High

1046701

LARP1
La-related protein 1

1

11

High-throughput

0.457

High

1046704

K2C74
Keratin, type II cytoskeletal 74

1

2

High-throughput

0.457

High

1046705

YTHD3
YTH domain-containing family protein 3

1

8

High-throughput

0.457

High

1046708

HORN
Hornerin

1

12

High-throughput

0.457

High

1046714

LS14A
Protein LSM14 homolog A

1

10

High-throughput

0.457

High

1046761

M1IP1
Mid1-interacting protein 1

1

1

High-throughput

0.457

High

1046764

ATD3A
ATPase family AAA domain-containing protein 3A

1

9

High-throughput

0.457

High

1046741

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

6

High-throughput

0.445

High

164885

SC16A
Protein transport protein Sec16A

1

15

High-throughput

0.437

High

922057

RL39
Large ribosomal subunit protein eL39

1

4

High-throughput

0.437

High

941771

RBM6
RNA-binding protein 6

1

8

High-throughput

0.437

High

949681

RL36A
Large ribosomal subunit protein eL42

1

11

High-throughput

0.437

High

1046685

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

1046691

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

1046695

PRC2B
Protein PRRC2B

1

20

High-throughput

0.437

High

1046696

RBM20
RNA-binding protein 20

1

5

High-throughput

0.437

High

1046697

ZMYM4
Zinc finger MYM-type protein 4

1

20

High-throughput

0.437

High

1046734

DDX27
Probable ATP-dependent RNA helicase DDX27

1

13

High-throughput

0.437

High

1046739

LENG8
Leukocyte receptor cluster member 8

1

7

High-throughput

0.437

High

1046750

DDX24
ATP-dependent RNA helicase DDX24

1

14

High-throughput

0.437

High

1046765

DDX18
ATP-dependent RNA helicase DDX18

1

20

High-throughput

0.437

High

1046770

PRR12
Proline-rich protein 12

1

20

High-throughput

0.437

High

1046773

RL26L
Ribosomal protein uL24-like

1

15

High-throughput

0.437

High

173026

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024