Protein: SPART
Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)

Gene: SPART
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q8N0X7

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005741 - mitochondrial outer membrane
GO:0005811 - lipid droplet
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1322302

ITCH
E3 ubiquitin-protein ligase Itchy homolog

8

10

Small-scale

0.751

High

1322309

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

6

10

Small-scale

0.738

High

1322315

SMUF1
E3 ubiquitin-protein ligase SMURF1

5

10

Small-scale

0.717

High

1322319

HECW2
E3 ubiquitin-protein ligase HECW2

2

10

High-throughput

0.628

High

253093

PLIN3
Perilipin-3

2

1

Small-scale

0.625

High

535285

BIP
Endoplasmic reticulum chaperone BiP

2

9

Small-scale

0.621

High

329464

EPN2
Epsin-2

2

3

High-throughput

0.606

High

531105

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

3

High-throughput

0.606

High

853489

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

4

High-throughput

0.606

High

1218597

OTU1
Ubiquitin thioesterase OTU1

2

3

High-throughput

0.606

High

1232970

OTU7B
OTU domain-containing protein 7B

2

6

High-throughput

0.606

High

1322300

OTUL
Ubiquitin thioesterase otulin

2

1

High-throughput

0.606

High

1322305

UBAC1
Ubiquitin-associated domain-containing protein 1

2

5

High-throughput

0.606

High

1322323

RABX5
Rab5 GDP/GTP exchange factor

2

2

High-throughput

0.606

High

1322313

SMUF2
E3 ubiquitin-protein ligase SMURF2

2

10

Small-scale

0.595

High

132157

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

9

Small-scale

0.586

High

242251

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

1107915

SQSTM
Sequestosome-1

2

4

High-throughput

0.584

High

1322318

WWOX
WW domain-containing oxidoreductase

2

3

High-throughput

0.584

High

1322306

DESI2
Deubiquitinase DESI2

2

0

High-throughput

0.580

High

620469

NUCL
Nucleolin

1

4

Small-scale

0.554

High

801412

HSPA9
Stress-70 protein, mitochondrial

1

11

Small-scale

0.554

High

1322301

OTUB2
Ubiquitin thioesterase OTUB2

2

1

High-throughput

0.553

High

1322314

GPR35
G-protein coupled receptor 35

1

2

High-throughput

0.541

High

1322324

DP13A
DCC-interacting protein 13-alpha

1

2

High-throughput

0.541

High

175115

SC16A
Protein transport protein Sec16A

1

5

High-throughput

0.536

High

249485

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

5

Small-scale

0.536

High

339531

ACSL3
Fatty acid CoA ligase Acsl3

1

5

Small-scale

0.536

High

348607

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

5

Small-scale

0.536

High

474814

VIME
Vimentin

1

11

Small-scale

0.536

High

532759

CH60
60 kDa heat shock protein, mitochondrial

1

4

Small-scale

0.536

High

625485

CSK22
Casein kinase II subunit alpha'

1

7

High-throughput

0.536

High

749962

KINH
Kinesin-1 heavy chain

1

5

Small-scale

0.536

High

921948

COPA
Coatomer subunit alpha

1

6

Small-scale

0.536

High

1026126

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.536

High

1123974

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

Small-scale

0.536

High

1134273

IMB1
Importin subunit beta-1

1

6

Small-scale

0.536

High

1161145

MK06
Mitogen-activated protein kinase 6

1

7

High-throughput

0.536

High

1322308

KLC2
Kinesin light chain 2

1

10

Small-scale

0.536

High

839792

EPS15
Epidermal growth factor receptor substrate 15

1

9

Small-scale

0.527

High

831048

CCNF
Cyclin-F

1

6

High-throughput

0.515

High

130982

HIP1
Huntingtin-interacting protein 1

1

9

High-throughput

0.515

High

562207

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.515

High

1322326

SHLB1
Endophilin-B1

1

6

High-throughput

0.515

High

336125

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

10

High-throughput

0.508

High

422555

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1098808

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

7

Small-scale

0.501

High

1259335

TBA1A
Tubulin alpha-1A chain

1

20

Small-scale

0.501

High

1322293

SPART
Spartin

1

17

Small-scale

0.501

High

298609

RAD17
Cell cycle checkpoint protein RAD17

1

3

High-throughput

0.489

High

634517

LMNB1
Lamin-B1

1

10

Small-scale

0.489

High

829457

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

Small-scale

0.489

High

346059

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

508267

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

High-throughput

0.479

High

552633

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

560448

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

567446

TCTP
Translationally-controlled tumor protein

1

2

High-throughput

0.479

High

589131

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

606909

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

642966

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.479

High

714262

PML
Protein PML

1

7

High-throughput

0.479

High

766685

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

832920

CETN2
Centrin-2

1

6

High-throughput

0.479

High

843752

HD
Huntingtin

1

3

High-throughput

0.479

High

867266

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

1067498

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1095705

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

14

High-throughput

0.479

High

1113655

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1128776

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1153832

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

1156147

ZYX
Zyxin

1

3

High-throughput

0.479

High

1156541

CCDC6
Coiled-coil domain-containing protein 6

1

11

High-throughput

0.479

High

1178243

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1233340

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1254593

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1289240

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

5

High-throughput

0.479

High

1289451

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1322294

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1322295

ASB11
Ankyrin repeat and SOCS box protein 11

1

10

High-throughput

0.479

High

1322296

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

6

High-throughput

0.479

High

1322297

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1322298

AKAP1
A-kinase anchor protein 1, mitochondrial

1

5

High-throughput

0.479

High

1322299

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.479

High

1322303

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1322307

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.479

High

1322311

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

1322316

DJC11
DnaJ homolog subfamily C member 11

1

8

High-throughput

0.479

High

1322321

TBK1
Serine/threonine-protein kinase TBK1

1

6

High-throughput

0.479

High

1322322

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1322325

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.479

High

275058

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

1322317

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

507271

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

13

Small-scale

0.445

High

911636

NCBP2
Nuclear cap-binding protein subunit 2

1

6

High-throughput

0.445

High

1227042

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.445

High

695916

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768625

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1096753

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.437

High

1241904

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

1276470

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1314301

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.437

High

1322310

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.437

High

1010947

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.426

High

1322304

PCFT
Proton-coupled folate transporter

1

0

High-throughput

0.426

High

1322320

POLK
DNA polymerase kappa

2

0

High-throughput

0.328

High

1027075

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1322312

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

505443

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025