Protein: INT8
Integrator complex subunit 8 (Int8) (Protein kaonashi-1)

Gene: INT8, INTS8
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q75QN2

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016180 - snRNA processing
GO:0032039 - integrator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243306

INT5
Integrator complex subunit 5

3

0

Small-scale

0.649

High

1260326

INT6
Integrator complex subunit 6

3

1

Small-scale

0.633

High

717873

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

0

High-throughput

0.602

High

994275

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

0

High-throughput

0.602

High

1260311

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

396392

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

954707

SEM1
26S proteasome complex subunit SEM1

2

0

Small-scale

0.547

High

130522

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

445209

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

542083

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

621904

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

723005

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

787757

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

912198

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.513

High

923508

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

958976

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

1065256

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1185162

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

High-throughput

0.513

High

1260307

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

1260315

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

1260316

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1260317

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

380639

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

1

High-throughput

0.489

High

619842

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.489

High

1260330

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

1260312

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

129205

MEN1
Menin

1

0

High-throughput

0.458

High

904864

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1004750

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1155489

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1229166

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

1260308

INT1
Integrator complex subunit 1

1

0

High-throughput

0.458

High

1260310

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1260322

INT10
Integrator complex subunit 10

1

0

Small-scale

0.458

High

1260325

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1260320

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

0

High-throughput

0.438

High

457515

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

1181390

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

1260319

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

1260327

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

182619

GP182
G-protein coupled receptor 182

2

0

High-throughput

0.313

High

1260314

OPALI
Opalin

2

0

High-throughput

0.313

High

1260328

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

0

High-throughput

0.313

High

249156

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

124387

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

139251

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

165971

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

378633

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

1098909

KLRD1
Natural killer cells antigen CD94

1

0

High-throughput

0.279

Low

1103706

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.279

Low

1260309

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1260313

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1260323

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

1260324

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1260331

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

1248963

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1254360

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1256916

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1260318

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1260321

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

380081

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.232

Low

1226935

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1260329

ASB4
Ankyrin repeat and SOCS box protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025