Protein: INT3
Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)

Gene: INT3, INTS3
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q68E01

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1229197

SOSB1
SOSS complex subunit B1

7

1

Small-scale

0.970

High

1229183

SOSB2
SOSS complex subunit B2

3

1

Small-scale

0.847

High

1229206

SOSSC
SOSS complex subunit C

2

0

Small-scale

0.765

High

1229213

INT6
Integrator complex subunit 6

7

2

Small-scale

0.750

High

717856

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

1

High-throughput

0.671

High

994263

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

1

Small-scale

0.667

High

912190

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.628

High

1048558

SSBP
Single-stranded DNA-binding protein, mitochondrial

3

0

Small-scale

0.613

High

1229207

INT9
Integrator complex subunit 9

2

1

High-throughput

0.611

High

1229188

CPNE2
Copine-2

2

0

High-throughput

0.602

High

621893

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.585

High

722988

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

912070

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

High-throughput

0.585

High

1229175

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

1229192

INT14
Integrator complex subunit 14

2

0

High-throughput

0.585

High

1214986

INT11
Integrator complex subunit 11

2

1

Small-scale

0.584

High

621664

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.559

High

1010757

SSBP2
Single-stranded DNA-binding protein 2

2

0

Small-scale

0.559

High

1229210

INT10
Integrator complex subunit 10

2

0

Small-scale

0.559

High

1101522

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

1

High-throughput

0.549

High

229340

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.549

High

351907

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.536

High

872428

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

1065238

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1162984

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

74517

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

130504

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

274624

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

388220

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

486573

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

542066

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

601725

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

787752

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

923502

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

958967

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

974250

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

0

High-throughput

0.513

High

1013070

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1091299

FOXL1
Forkhead box protein L1

1

0

High-throughput

0.513

High

1111043

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1134614

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

1150237

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

1229184

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1229193

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1229196

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1229199

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1229202

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

1229200

DNAI2
Dynein axonemal intermediate chain 2

1

1

High-throughput

0.489

High

1229203

KLK15
Kallikrein-15

1

1

High-throughput

0.489

High

422311

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

964328

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1229215

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

285332

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

404129

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

718134

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

1

High-throughput

0.479

High

977521

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

1

High-throughput

0.479

High

980842

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1206355

INT6L
Integrator complex subunit 6-like

1

2

High-throughput

0.479

High

1229171

ZN687
Zinc finger protein 687

1

1

High-throughput

0.479

High

1229180

ZN592
Zinc finger protein 592

1

1

High-throughput

0.479

High

1229182

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1229191

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

1229205

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.479

High

192824

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

260077

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

291663

XRP2
Protein XRP2

1

0

High-throughput

0.458

High

537334

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

588914

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

626262

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.458

High

667336

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

695699

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

728292

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.458

High

768416

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

879184

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

897307

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

906071

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

965017

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

976098

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

979822

H4
Histone H4

1

0

High-throughput

0.458

High

1004699

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1088874

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1109459

ATR
Serine/threonine-protein kinase ATR

1

0

Small-scale

0.458

High

1113377

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1130074

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.458

High

1137349

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1138309

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1155461

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1229161

NAIF1
Nuclear apoptosis-inducing factor 1

1

0

High-throughput

0.458

High

1229162

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1229163

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

1229165

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1229166

INT8
Integrator complex subunit 8

1

0

High-throughput

0.458

High

1229167

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1229170

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1229172

INT1
Integrator complex subunit 1

1

0

High-throughput

0.458

High

1229173

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

1229178

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

1229185

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1229186

INT12
Integrator complex subunit 12

1

0

High-throughput

0.458

High

1229189

INT4
Integrator complex subunit 4

1

0

High-throughput

0.458

High

1229190

INT15
Integrator complex subunit 15

1

0

High-throughput

0.458

High

1229201

INT2
Integrator complex subunit 2

1

0

High-throughput

0.458

High

1229204

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1229208

INT7
Integrator complex subunit 7

1

0

High-throughput

0.458

High

1229209

INT13
Integrator complex subunit 13

1

0

High-throughput

0.458

High

1229211

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1229214

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

0

High-throughput

0.458

High

886073

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.445

High

1229181

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

851065

LPAR6
Lysophosphatidic acid receptor 6

1

1

High-throughput

0.437

High

143447

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

926365

BLM
RecQ-like DNA helicase BLM

1

0

Small-scale

0.426

High

1229194

CDX2
Homeobox protein CDX-2

1

0

High-throughput

0.426

High

231591

PRKY
Putative serine/threonine-protein kinase PRKY

1

1

High-throughput

0.407

High

1229169

CMTD1
Catechol O-methyltransferase domain-containing protein 1

4

0

High-throughput

0.360

High

1229176

SIGL1
SIGLEC family-like protein 1

3

0

High-throughput

0.345

High

587350

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

0

High-throughput

0.328

High

749214

CD70
CD70 antigen

2

0

High-throughput

0.328

High

253847

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

322145

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.279

Low

341429

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.279

Low

866718

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

1229164

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1229174

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1229195

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.279

Low

1229198

TX13B
Testis-expressed protein 13B

1

0

High-throughput

0.279

Low

1229212

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

1229216

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

412087

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1229179

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

1229187

FAF2
FAS-associated factor 2

1

0

High-throughput

0.249

Low

171480

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.232

Low

437706

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

640189

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.232

Low

683258

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

1229168

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1229177

F174A
Membrane protein FAM174A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025