Protein: 4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)

Gene: 4EBP1, EIF4EBP1
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q13541

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008190 - eukaryotic initiation factor 4E binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445546

IF4E
Eukaryotic translation initiation factor 4E

58

15

Small-scale

0.997

High

252059

IF4E2
Eukaryotic translation initiation factor 4E type 2

5

15

Small-scale

0.935

High

839263

MTOR
Serine/threonine-protein kinase mTOR

31

7

Small-scale

0.770

High

66985

I4E1B
Eukaryotic translation initiation factor 4E type 1B

3

15

High-throughput

0.768

High

1109560

RPTOR
Regulatory-associated protein of mTOR

21

2

Small-scale

0.768

High

1109554

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

1

Small-scale

0.655

High

1048844

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

1102152

ATM
Serine-protein kinase ATM

2

7

Small-scale

0.608

High

681809

RBTN2
Rhombotin-2

2

0

High-throughput

0.580

High

893690

MEOX1
Homeobox protein MOX-1

2

0

High-throughput

0.580

High

1007916

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.580

High

1109561

ZN655
Zinc finger protein 655

2

0

High-throughput

0.580

High

1109563

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1109571

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

587074

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

944799

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.536

High

1109558

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.536

High

1109567

BTBD1
BTB/POZ domain-containing protein 1

1

1

High-throughput

0.536

High

1109549

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.513

High

1109559

FBX11
F-box only protein 11

1

0

High-throughput

0.513

High

1109565

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.512

High

1109576

AGO2
Protein argonaute-2

1

0

Small-scale

0.512

High

349065

LATS1
Serine/threonine-protein kinase LATS1

1

1

Small-scale

0.501

High

703579

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.501

High

1008134

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.501

High

1109553

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.501

High

1109566

LST8
Target of rapamycin complex subunit LST8

1

1

Small-scale

0.501

High

891525

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

603263

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

1097662

STK3
Serine/threonine-protein kinase 3

1

0

Small-scale

0.480

High

1109552

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.480

High

1109555

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.480

High

1109572

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

Small-scale

0.480

High

131419

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.479

High

187709

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

2

High-throughput

0.479

High

187960

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

3

High-throughput

0.479

High

216083

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

4

High-throughput

0.479

High

295161

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

3

High-throughput

0.479

High

363243

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

410821

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.479

High

939319

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.479

High

949350

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.479

High

1046994

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

4

High-throughput

0.479

High

1102822

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.479

High

1109548

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.479

High

1109550

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.479

High

1109551

SLMAP
Sarcolemmal membrane-associated protein

1

1

High-throughput

0.479

High

1109556

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.479

High

1109557

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.479

High

1109564

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.479

High

1109568

KLH25
Kelch-like protein 25

1

1

Small-scale

0.479

High

1109569

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

1109570

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

1109573

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

1

High-throughput

0.479

High

1109574

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1109577

ANGE1
Protein angel homolog 1

1

1

High-throughput

0.479

High

1109579

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.479

High

468343

HS90B
Heat shock protein HSP 90-beta

1

0

Small-scale

0.458

High

827770

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

970457

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

991021

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

Small-scale

0.458

High

1109546

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

0

High-throughput

0.458

High

1109547

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1109562

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

Small-scale

0.458

High

1109575

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

921500

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.438

High

1007683

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.426

High

1109578

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

506700

CTF8
Chromosome transmission fidelity protein 8 homolog

1

0

High-throughput

0.282

High

720471

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

Small-scale

0.249

Low

1109580

EID1
EP300-interacting inhibitor of differentiation 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025