Protein: 3MG
DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)

Gene: 3MG, MPG
Organism: Homo sapiens
Interactions: 120
UniProt ID: P29372

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0003677 - DNA binding
GO:0003905 - alkylbase DNA N-glycosylase activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

395549

ESR1
Estrogen receptor

3

1

Small-scale

0.660

High

711662

DHB14
L-fucose dehydrogenase

3

0

High-throughput

0.654

High

327554

ELP1
Elongator complex protein 1

3

0

High-throughput

0.638

High

711649

ELP2
Elongator complex protein 2

3

0

High-throughput

0.638

High

711670

ELP3
Elongator complex protein 3

3

0

High-throughput

0.638

High

711606

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.586

High

711610

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

711620

RD23A
UV excision repair protein RAD23 homolog A

2

0

Small-scale

0.571

High

711612

CRK
Adapter molecule crk

2

0

High-throughput

0.569

High

587984

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

694694

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

711607

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

711619

CAZA1
F-actin-capping protein subunit alpha-1

2

0

Small-scale

0.559

High

711638

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.559

High

711657

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

404688

PRIO
Major prion protein

1

0

Small-scale

0.537

High

711674

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.529

High

413254

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

446679

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

693550

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

711655

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.513

High

711667

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.513

High

711672

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.513

High

362007

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.493

High

532382

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

636819

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.493

High

711611

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.493

High

711656

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.493

High

421556

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

711685

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

681111

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.479

High

711647

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

1

Small-scale

0.479

High

711653

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

711658

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.479

High

711660

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

711661

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

1

Small-scale

0.479

High

212161

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

Small-scale

0.458

High

217867

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

228185

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

270892

CLAP2
CLIP-associating protein 2

1

0

Small-scale

0.458

High

324571

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

371248

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

405182

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

418848

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.458

High

442242

GELS
Gelsolin

1

0

Small-scale

0.458

High

568365

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

570841

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

573001

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

611776

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

617656

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

635564

FILA
Filaggrin

1

0

Small-scale

0.458

High

666254

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

0

High-throughput

0.458

High

680785

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

711608

RFC4
Replication factor C subunit 4

1

0

Small-scale

0.458

High

711609

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.458

High

711613

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

711614

FXR2
RNA-binding protein FXR2

1

0

Small-scale

0.458

High

711615

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

711616

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

711617

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

711618

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.458

High

711621

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

711622

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

711623

H4
Histone H4

1

0

High-throughput

0.458

High

711624

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

711625

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

711626

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

High-throughput

0.458

High

711627

H31
Histone H3.1

1

0

High-throughput

0.458

High

711628

SET
Protein SET

1

0

High-throughput

0.458

High

711629

CSTF1
Cleavage stimulation factor subunit 1

1

0

Small-scale

0.458

High

711630

EXOS9
Exosome complex component RRP45

1

0

Small-scale

0.458

High

711631

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

711632

SRSF1
Serine/arginine-rich splicing factor 1

1

0

Small-scale

0.458

High

711633

NCBP1
Nuclear cap-binding protein subunit 1

1

0

Small-scale

0.458

High

711636

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

711637

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

Small-scale

0.458

High

711639

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

711643

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

Small-scale

0.458

High

711644

MIDN
Midnolin

1

0

High-throughput

0.458

High

711646

OBSCN
Obscurin

1

0

Small-scale

0.458

High

711651

LARP4
La-related protein 4

1

0

Small-scale

0.458

High

711654

FUBP2
Far upstream element-binding protein 2

1

0

Small-scale

0.458

High

711659

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

Small-scale

0.458

High

711665

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

711666

RGAP1
Rac GTPase-activating protein 1

1

0

Small-scale

0.458

High

711668

DHX33
ATP-dependent RNA helicase DHX33

1

0

Small-scale

0.458

High

711669

MOB1A
MOB kinase activator 1A

1

0

High-throughput

0.458

High

711671

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

711676

TFP11
Tuftelin-interacting protein 11

1

0

Small-scale

0.458

High

711677

MO4L1
Mortality factor 4-like protein 1

1

0

Small-scale

0.458

High

711678

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

711681

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.458

High

711682

KDM2A
Lysine-specific demethylase 2A

1

0

Small-scale

0.458

High

711683

RRP7A
Ribosomal RNA-processing protein 7 homolog A

1

0

Small-scale

0.458

High

711684

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.458

High

711686

NOC2L
Nucleolar complex protein 2 homolog

1

0

Small-scale

0.458

High

711635

NOG2
Nucleolar GTP-binding protein 2

1

1

Small-scale

0.437

High

711663

GNL3
Guanine nucleotide-binding protein-like 3

1

1

Small-scale

0.437

High

711679

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

429361

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

711673

KBTB4
Kelch repeat and BTB domain-containing protein 4

3

0

High-throughput

0.347

High

105403

APRIO
Alternative prion protein

1

0

Small-scale

0.292

High

182472

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.282

High

654473

FBLN1
Fibulin-1

1

0

High-throughput

0.269

Low

130007

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.249

Low

653707

LSHR
Lutropin-choriogonadotropic hormone receptor

1

0

Small-scale

0.249

Low

711634

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

0

High-throughput

0.249

Low

711640

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.249

Low

711641

CDSN
Corneodesmosin

1

0

Small-scale

0.249

Low

711642

CYTM
Cystatin-M

1

0

Small-scale

0.249

Low

711645

KPRP
Keratinocyte proline-rich protein

1

0

Small-scale

0.249

Low

711648

PR38B
Pre-mRNA-splicing factor 38B

1

0

Small-scale

0.249

Low

711650

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

711652

SPA12
Serpin A12

1

0

Small-scale

0.249

Low

711664

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

711675

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

711680

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

0

High-throughput

0.249

Low

239012

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low

254827

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025