Protein: LERL1
Leptin receptor overlapping transcript-like 1 (Endospanin-2)

Gene: LERL1, LEPROTL1
Organism: Homo sapiens
Interactions: 82
UniProt ID: O95214

Gene Ontology (top 5):
GO:0005768 - endosome
GO:0016020 - membrane
GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway
GO:0042802 - identical protein binding
GO:0060400 - negative regulation of growth hormone receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329617

MSRE
Macrophage scavenger receptor types I and II

4

1

High-throughput

0.683

High

329649

EDA
Ectodysplasin-A

4

1

High-throughput

0.683

High

329652

KLRG1
Killer cell lectin-like receptor subfamily G member 1

3

1

High-throughput

0.667

High

329612

TM50A
Transmembrane protein 50A

2

8

High-throughput

0.606

High

329619

CTR1
High affinity cationic amino acid transporter 1

2

1

High-throughput

0.606

High

329625

TM50B
Transmembrane protein 50B

2

8

High-throughput

0.606

High

329635

MF14B
Hippocampus abundant transcript-like protein 1

2

1

High-throughput

0.606

High

329679

CLC2D
C-type lectin domain family 2 member D

2

1

High-throughput

0.606

High

140089

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

252572

TSN2
Tetraspanin-2

2

0

High-throughput

0.580

High

329610

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.580

High

329624

EMP1
Epithelial membrane protein 1

2

0

High-throughput

0.580

High

329631

MALL
MAL-like protein

2

0

High-throughput

0.580

High

329636

TMM42
Transmembrane protein 42

2

0

High-throughput

0.580

High

329637

STING
Stimulator of interferon genes protein

2

0

High-throughput

0.580

High

329642

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

329645

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

329648

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

329651

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

329653

TMM19
Transmembrane protein 19

2

0

High-throughput

0.580

High

329657

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

329665

LRC4C
Leucine-rich repeat-containing protein 4C

2

0

High-throughput

0.580

High

329668

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.580

High

329671

TM248
Transmembrane protein 248

2

0

High-throughput

0.580

High

329673

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.580

High

329678

NAT8
N-acetyltransferase 8

2

0

High-throughput

0.580

High

329681

PEX16
Peroxisomal membrane protein PEX16

2

0

High-throughput

0.580

High

194661

FFAR2
Free fatty acid receptor 2

2

1

High-throughput

0.553

High

329621

CXA5
Gap junction alpha-5 protein

2

2

High-throughput

0.553

High

329623

CXA8
Gap junction alpha-8 protein

2

2

High-throughput

0.553

High

329638

STX12
Syntaxin-12

2

2

High-throughput

0.553

High

329641

ORML3
ORM1-like protein 3

2

1

High-throughput

0.553

High

329654

REEP6
Receptor expression-enhancing protein 6

2

1

High-throughput

0.553

High

329660

YIPF2
Protein YIPF2

2

1

High-throughput

0.553

High

329663

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.553

High

329667

S35C2
Solute carrier family 35 member C2

2

1

High-throughput

0.553

High

329680

TMX2
Thioredoxin-related transmembrane protein 2

2

1

High-throughput

0.553

High

48185

A0AVG3
t-SNARE domain containing 1

1

2

High-throughput

0.515

High

329639

NRM
Nurim

1

0

High-throughput

0.493

High

329662

TMM60
Transmembrane protein 60

1

0

High-throughput

0.493

High

193382

GPR42
G-protein coupled receptor 42

1

1

High-throughput

0.470

High

329676

ORML1
ORM1-like protein 1

1

1

High-throughput

0.470

High

329656

TSNA1
t-SNARE domain-containing protein 1

1

2

High-throughput

0.439

High

65507

TV23A
Golgi apparatus membrane protein TVP23 homolog A

2

0

High-throughput

0.316

High

166235

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

0

High-throughput

0.316

High

329611

CLD7
Claudin-7

2

0

High-throughput

0.316

High

329613

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

2

0

High-throughput

0.316

High

329615

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

329616

TMM11
Transmembrane protein 11, mitochondrial

2

0

High-throughput

0.316

High

329622

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

329626

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.316

High

329627

CP4F2
Cytochrome P450 4F2

2

0

High-throughput

0.316

High

329628

FMO1
Flavin-containing monooxygenase 1

2

0

High-throughput

0.316

High

329630

CLM6
CMRF35-like molecule 6

2

0

High-throughput

0.316

High

329632

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.316

High

329633

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

329634

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

329640

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.316

High

329643

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

329644

GP152
Probable G-protein coupled receptor 152

2

0

High-throughput

0.316

High

329646

PAQR8
Membrane progestin receptor beta

2

0

High-throughput

0.316

High

329647

LMBR1
Limb region 1 protein homolog

2

0

High-throughput

0.316

High

329650

S2546
Mitochondrial outer membrane protein SLC25A46

2

0

High-throughput

0.316

High

329655

ZDH15
Palmitoyltransferase ZDHHC15

2

0

High-throughput

0.316

High

329658

RNF5
E3 ubiquitin-protein ligase RNF5

2

0

High-throughput

0.316

High

329659

SFXN3
Sideroflexin-3

2

0

High-throughput

0.316

High

329661

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.316

High

329664

SYNG1
Synapse differentiation-inducing gene protein 1

2

0

High-throughput

0.316

High

329666

JPH1
Junctophilin-1

2

0

High-throughput

0.316

High

329669

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

0

High-throughput

0.316

High

329670

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

329674

SPG21
Maspardin

2

0

High-throughput

0.316

High

329675

VAPA
Vesicle-associated membrane protein-associated protein A

2

0

High-throughput

0.316

High

329677

LPAR3
Lysophosphatidic acid receptor 3

2

0

High-throughput

0.316

High

155427

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.268

Low

328214

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.268

Low

329629

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

329614

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

329618

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.251

Low

329620

MOT8
Monocarboxylate transporter 8

1

0

High-throughput

0.251

Low

329672

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025