Protein: DEN6A
Protein DENND6A (DENN domain-containing protein 6A)

Gene: DEN6A, DENND6A
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q8IWF6

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0043231 - intracellular membrane-bounded organelle
GO:0055037 - recycling endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788958

TGFR2
TGF-beta receptor type-2

3

1

High-throughput

0.667

High

571469

GLU2B
Glucosidase 2 subunit beta

3

0

High-throughput

0.638

High

1252065

RN19B
E3 ubiquitin-protein ligase RNF19B

2

1

High-throughput

0.628

High

1010070

DLK1
Protein delta homolog 1

2

1

High-throughput

0.611

High

914446

EFNB2
Ephrin-B2

3

2

High-throughput

0.609

High

1310052

KS6C1
Ribosomal protein S6 kinase delta-1

3

2

High-throughput

0.604

High

1310050

TPC2
Two pore channel protein 2

2

0

High-throughput

0.602

High

258972

DNJA2
DnaJ homolog subfamily A member 2

2

0

High-throughput

0.585

High

1153472

EFNB3
Ephrin-B3

2

2

High-throughput

0.574

High

1022903

EFNB1
Ephrin-B1

1

2

High-throughput

0.536

High

1116822

AVR2B
Activin receptor type-2B

1

1

High-throughput

0.536

High

239120

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

721724

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

1054613

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.513

High

1144063

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1181482

EMAL3
Echinoderm microtubule-associated protein-like 3

1

0

High-throughput

0.513

High

1310047

DEN6B
Protein DENND6B

1

0

High-throughput

0.513

High

1310056

RABE2
Rab GTPase-binding effector protein 2

1

0

High-throughput

0.513

High

540549

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

541578

FGFR1
Fibroblast growth factor receptor 1

1

2

High-throughput

0.479

High

562196

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

898111

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

1

High-throughput

0.479

High

901921

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

932096

EPHA4
Ephrin type-A receptor 4

1

1

High-throughput

0.479

High

955355

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

956377

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

976394

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

1120758

DSG2
Desmoglein-2

1

1

High-throughput

0.479

High

1124488

MAP7
Ensconsin

1

1

High-throughput

0.479

High

1155363

RB11B
Ras-related protein Rab-11B

1

2

High-throughput

0.479

High

1310045

LMTK2
Serine/threonine-protein kinase LMTK2

1

3

High-throughput

0.479

High

1310048

NBEA
Neurobeachin

1

1

High-throughput

0.479

High

1310055

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1310057

PKHA5
Pleckstrin homology domain-containing family A member 5

1

1

High-throughput

0.479

High

1310063

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

189684

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

315757

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

317883

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

507266

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

715663

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

1040329

DYST
Dystonin

1

0

High-throughput

0.458

High

1065732

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

1187485

AR13B
ADP-ribosylation factor-like protein 13B

1

0

High-throughput

0.458

High

1191439

GRDN
Girdin

1

0

High-throughput

0.458

High

1195300

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.458

High

1220628

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1276201

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1310053

RFIP5
Rab11 family-interacting protein 5

1

0

High-throughput

0.458

High

1310059

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.458

High

1310060

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.458

High

1310062

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.458

High

1310065

WDR7
WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1310066

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

0

High-throughput

0.458

High

601363

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.437

High

710352

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.437

High

900906

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

1037006

DSC2
Desmocollin-2

1

1

High-throughput

0.437

High

1310046

ARL10
ADP-ribosylation factor-like protein 10

1

1

High-throughput

0.437

High

1310054

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.437

High

1270270

BT2A1
Butyrophilin subfamily 2 member A1

3

0

High-throughput

0.347

High

1310058

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1310064

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

0

High-throughput

0.347

High

829903

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.328

High

1142501

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.328

High

1310051

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.328

High

190427

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

406905

MAS
Proto-oncogene Mas

1

0

High-throughput

0.279

Low

596500

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.279

Low

1007877

X3CL1
Fractalkine

1

0

High-throughput

0.279

Low

1219980

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1310049

CADM4
Cell adhesion molecule 4

1

0

High-throughput

0.279

Low

1310061

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

178807

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.249

Low

218427

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

695883

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

979943

H4
Histone H4

1

0

High-throughput

0.249

Low

998514

H31
Histone H3.1

1

0

High-throughput

0.249

Low

1120571

LRP8
Low-density lipoprotein receptor-related protein 8

1

0

High-throughput

0.249

Low

1233326

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025