Protein: CY1
Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)

Gene: CY1, CYC1
Organism: Homo sapiens
Interactions: 121
UniProt ID: P08574

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c
GO:0008121 - quinol-cytochrome-c reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168956

QCR8
Cytochrome b-c1 complex subunit 8

4

1

High-throughput

0.881

High

462752

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.770

High

471705

QCR9
Cytochrome b-c1 complex subunit 9

2

0

High-throughput

0.748

High

471616

QCR7
Cytochrome b-c1 complex subunit 7

3

2

High-throughput

0.662

High

471641

CYC
Cytochrome c

1

1

Small-scale

0.647

High

471624

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.638

High

471634

CCHL
Holocytochrome c-type synthase

3

0

High-throughput

0.638

High

471627

HD
Huntingtin

2

1

High-throughput

0.588

High

395348

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

471679

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.547

High

471617

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

173841

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.513

High

370969

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

471613

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

471630

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

471647

CLN3
Battenin

1

0

High-throughput

0.513

High

471665

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

471670

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

471676

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

471696

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

471707

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

471654

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.493

High

415284

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.479

High

471619

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

471622

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

3

High-throughput

0.479

High

471625

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

471637

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

471642

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

471678

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

471685

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

471686

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

471699

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

896

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.464

High

471644

GRSF1
G-rich sequence factor 1

1

0

Small-scale

0.460

High

124571

EYA2
Protein phosphatase EYA2

1

0

High-throughput

0.458

High

137621

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

156863

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

222649

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

240537

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

283770

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

292057

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

319316

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

348323

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

411216

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

471612

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

471615

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

471618

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

471620

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.458

High

471621

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

471631

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

471632

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

471635

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

471636

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.458

High

471638

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

471639

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

471645

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

471649

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

471651

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.458

High

471652

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

471655

MIDN
Midnolin

1

0

High-throughput

0.458

High

471658

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

471660

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

471667

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

471671

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

471673

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

471675

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

471680

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

471681

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

471684

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

471687

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

471688

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

471690

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

471691

MTMRC
Myotubularin-related protein 12

1

0

High-throughput

0.458

High

471694

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

471695

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

471697

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

471698

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

471700

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

0

Small-scale

0.458

High

471701

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

471704

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

471706

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

471708

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

429168

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

471628

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.445

High

471629

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

471633

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.445

High

471653

S39AE
Metal cation symporter ZIP14

1

4

High-throughput

0.445

High

471662

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.445

High

471669

S39AB
Zinc transporter ZIP11

1

4

High-throughput

0.445

High

471677

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.445

High

471693

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.445

High

66418

ASB14
Ankyrin repeat and SOCS box protein 14

1

1

High-throughput

0.437

High

208453

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

471640

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

471657

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

229206

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.426

High

255967

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

471626

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

471648

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.426

High

471656

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

471659

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

471661

S27A4
Long-chain fatty acid transport protein 4

1

0

High-throughput

0.426

High

471702

S52A3
Solute carrier family 52, riboflavin transporter, member 3

1

0

High-throughput

0.426

High

471692

S39A8
Metal cation symporter ZIP8

1

4

High-throughput

0.407

High

471614

RALB
Ras-related protein Ral-B

2

0

High-throughput

0.298

High

471646

PAK1
Serine/threonine-protein kinase PAK 1

2

0

High-throughput

0.298

High

471668

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.279

Low

471689

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

471666

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.268

Low

105159

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

377366

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

471623

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

471643

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.249

Low

471650

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

471663

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

471664

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

471672

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

471674

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

471682

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

471683

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

471703

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025