Protein: GPN1
GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1)

Gene: GPN1
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q9HCN4

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1439343

GPN3
GPN-loop GTPase 3

8

10

Small-scale

0.964

High

1437307

GPN2
GPN-loop GTPase 2

7

10

Small-scale

0.962

High

1313054

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

7

3

High-throughput

0.747

High

976156

RPB7
DNA-directed RNA polymerase II subunit RPB7

6

4

High-throughput

0.732

High

723101

RPB2
DNA-directed RNA polymerase II subunit RPB2

5

13

Small-scale

0.715

High

912239

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

5

7

High-throughput

0.712

High

621757

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

8

High-throughput

0.694

High

1439332

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

6

High-throughput

0.691

High

1439335

RPC2
DNA-directed RNA polymerase III subunit RPC2

4

13

High-throughput

0.691

High

621974

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

3

High-throughput

0.675

High

1439334

RPC5
DNA-directed RNA polymerase III subunit RPC5

3

1

High-throughput

0.667

High

132311

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

3

Small-scale

0.656

High

667466

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

9

High-throughput

0.656

High

165095

RPC1
DNA-directed RNA polymerase III subunit RPC1

3

9

High-throughput

0.650

High

1439336

PIHD1
PIH1 domain-containing protein 1

4

1

High-throughput

0.633

High

180406

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

8

High-throughput

0.628

High

340039

RPA1
DNA-directed RNA polymerase I subunit RPA1

2

9

High-throughput

0.628

High

681931

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

959061

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

3

High-throughput

0.628

High

1416237

RPAP1
RNA polymerase II-associated protein 1

4

3

Small-scale

0.625

High

1232023

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

2

High-throughput

0.617

High

192861

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

1

High-throughput

0.611

High

1114358

CUL3
Cullin-3

2

3

High-throughput

0.611

High

1399357

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

6

High-throughput

0.611

High

983710

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

4

High-throughput

0.601

High

506031

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

2

High-throughput

0.558

High

998043

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.550

High

1439338

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.549

High

191108

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.536

High

430648

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

1

High-throughput

0.536

High

445069

S10A9
Protein S100-A9

1

1

High-throughput

0.536

High

923543

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

5

High-throughput

0.536

High

1161224

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1347157

WDR48
WD repeat-containing protein 48

1

2

High-throughput

0.536

High

1371873

CUL5
Cullin-5

1

3

High-throughput

0.536

High

1428634

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.536

High

1430207

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.536

High

1437310

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

13

High-throughput

0.536

High

1439339

UXT
Protein UXT

1

1

High-throughput

0.536

High

1439342

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.536

High

1439346

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

5

High-throughput

0.536

High

1439347

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

4

High-throughput

0.536

High

354255

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

High-throughput

0.518

High

220023

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

287480

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

872765

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

874871

SPB4
Serpin B4

1

0

High-throughput

0.513

High

1364827

F168A
Protein FAM168A

1

1

High-throughput

0.489

High

654135

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.486

High

173401

XPO1
Exportin-1

1

13

High-throughput

0.479

High

316035

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

316444

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

High-throughput

0.479

High

468826

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

508671

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

589752

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

610903

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

729465

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.479

High

787792

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

5

High-throughput

0.479

High

799489

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

801540

HSPA9
Stress-70 protein, mitochondrial

1

2

High-throughput

0.479

High

821586

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

862477

YAP1
Transcriptional coactivator YAP1

1

5

Small-scale

0.479

High

876184

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.479

High

899246

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.479

High

899596

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.479

High

912131

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

3

High-throughput

0.479

High

938813

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

2

High-throughput

0.479

High

1096823

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1120350

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.479

High

1138656

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1178392

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1217618

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

5

High-throughput

0.479

High

1435171

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

1435318

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1439333

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

1439340

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1439344

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.479

High

1439345

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

326378

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

537945

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

696571

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714439

PML
Protein PML

1

0

High-throughput

0.458

High

769239

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831464

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

911118

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.458

High

971112

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1027773

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

1105099

TCOF
Treacle protein

1

0

High-throughput

0.458

High

1151296

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

1157942

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

1247003

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1338384

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1350457

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1439341

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

High-throughput

0.458

High

1439349

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.458

High

516806

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

75729

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

1435877

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.437

High

1439337

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.437

High

1253170

NBEL2
Neurobeachin-like protein 2

1

0

High-throughput

0.426

High

1428851

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.426

High

69556

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

262315

SCN2B
Sodium channel regulatory subunit beta-2

1

2

High-throughput

0.407

High

505981

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

516872

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

7

High-throughput

0.407

High

1313088

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

1349510

LRC20
Leucine-rich repeat-containing protein 20

1

0

High-throughput

0.279

Low

1255634

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1433948

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

379400

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.232

Low

423850

APOD
Apolipoprotein D

1

0

High-throughput

0.232

Low

1273087

ZN627
Zinc finger protein 627

1

0

High-throughput

0.232

Low

1439348

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025