Protein: IPYR
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)

Gene: IPYR, PPA1
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q15181

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004427 - inorganic diphosphate phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006796 - phosphate-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1143976

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

6

High-throughput

0.618

High

372080

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.585

High

830776

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

410856

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.576

High

563794

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

1143946

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

1143968

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

783584

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

1143995

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

1143958

LCA5
Lebercilin

2

1

High-throughput

0.521

High

413873

P53
Cellular tumor antigen p53

1

0

High-throughput

0.518

High

415588

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

1105127

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

1139708

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.518

High

213936

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

361253

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

385762

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

1051236

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

508007

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

774367

BASI
Basigin

1

0

High-throughput

0.493

High

898665

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.493

High

484543

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

711895

LTK
Leukocyte tyrosine kinase receptor

1

2

High-throughput

0.489

High

1143970

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.489

High

126608

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.479

High

168537

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

1

High-throughput

0.479

High

241737

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

466264

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

476151

ANXA5
Annexin A5

1

2

High-throughput

0.479

High

552593

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

568243

PLST
Plastin-3

1

2

High-throughput

0.479

High

581062

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

601298

RHOQ
Rho-related GTP-binding protein RhoQ

1

8

High-throughput

0.479

High

606794

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

799135

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

824158

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.479

High

891565

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.479

High

910062

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

953460

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

955190

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

962069

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

970535

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

978019

RHOB
Rho-related GTP-binding protein RhoB

1

9

High-throughput

0.479

High

988381

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

1106893

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1138224

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1143943

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

1143953

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

1143954

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1143955

RHOU
Rho-related GTP-binding protein RhoU

1

9

High-throughput

0.479

High

1143956

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1143964

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1143965

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1143966

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1143978

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1143981

MYO10
Unconventional myosin-X

1

1

Small-scale

0.479

High

1143989

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1143990

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

1143992

PA2G4
Proliferation-associated protein 2G4

1

1

High-throughput

0.479

High

353341

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

1143991

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.470

High

510018

HMN1
Humanin-like 1

1

0

Small-scale

0.460

High

1143960

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

123392

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

157402

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

164344

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

188891

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

293716

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

324879

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

345852

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

361889

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

389375

FINC
Fibronectin

1

0

High-throughput

0.458

High

400865

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

446427

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

447044

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

488794

FURIN
Furin

1

0

High-throughput

0.458

High

537196

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

693317

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.458

High

762328

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

849349

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

957388

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

957742

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

995608

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1113155

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1117272

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1135682

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1143944

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1143947

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1143948

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1143949

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.458

High

1143951

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1143957

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1143959

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

1143961

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1143967

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1143971

NECD
Necdin

1

0

High-throughput

0.458

High

1143972

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

1143973

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1143980

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1143982

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.458

High

1143983

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1143985

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1143986

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1143987

COPZ2
Coatomer subunit zeta-2

1

0

High-throughput

0.458

High

1143945

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

1

High-throughput

0.457

High

328019

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

404796

PRIO
Major prion protein

1

1

High-throughput

0.445

High

1143950

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

1143977

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

105969

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

259979

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

318782

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

406201

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.437

High

411969

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

560399

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

768249

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

879111

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1031378

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1063263

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.437

High

1143963

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1143969

RHOV
Rho-related GTP-binding protein RhoV

1

8

High-throughput

0.437

High

1143974

RHBT2
Rho-related BTB domain-containing protein 2

1

8

High-throughput

0.437

High

184637

MK13
Mitogen-activated protein kinase 13

1

0

Small-scale

0.426

High

529831

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

619807

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

1143952

OLFM4
Olfactomedin-4

1

0

High-throughput

0.426

High

1143984

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

429925

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

886876

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

474000

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.249

Low

695517

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

832722

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

1081270

LR74A
Leucine-rich repeat-containing protein 74A

1

0

High-throughput

0.249

Low

1143962

ENOX1
Ecto-NOX disulfide-thiol exchanger 1

1

0

High-throughput

0.249

Low

1143975

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1143979

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.249

Low

1143988

EPHA6
Ephrin type-A receptor 6

1

0

High-throughput

0.249

Low

1143993

ZKSC5
Zinc finger protein with KRAB and SCAN domains 5

1

0

High-throughput

0.249

Low

1143994

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025