Protein: SPT2
Protein SPT2 (Negative regulator of Ty transcription)

Gene: SPT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 67
UniProt ID: P06843

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000217 - DNA secondary structure binding
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449387

CSK21
Casein kinase II subunit alpha

2

1

Small-scale

0.639

High

449394

CSK22
Casein kinase II subunit alpha'

2

1

Small-scale

0.639

High

449426

IMA1
Importin subunit alpha

2

0

High-throughput

0.595

High

449433

HIF1
HAT1-interacting factor 1

2

0

Small-scale

0.576

High

449420

MCM6
DNA replication licensing factor MCM6

2

0

Small-scale

0.570

High

449419

CSK2B
Casein kinase II subunit beta

2

1

Small-scale

0.558

High

449415

SAP1
Protein SAP1

1

1

Small-scale

0.523

High

449385

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.513

High

449397

NPR1
Nitrogen permease reactivator protein

1

0

High-throughput

0.513

High

449402

XPO1
Exportin-1

1

0

High-throughput

0.513

High

449406

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.513

High

449410

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.513

High

449414

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.513

High

449422

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.513

High

449427

RLI1
Translation initiation factor RLI1

1

0

High-throughput

0.513

High

449429

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.513

High

449430

STE23
A-factor-processing enzyme

1

0

High-throughput

0.513

High

366881

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.500

High

449375

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.500

High

449382

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

449391

ADT3
ADP,ATP carrier protein 3

1

1

High-throughput

0.489

High

449418

SGN1
RNA-binding protein SGN1

1

1

High-throughput

0.489

High

149185

FOB1
DNA replication fork-blocking protein FOB1

1

0

High-throughput

0.486

High

449428

GCN5
Histone acetyltransferase GCN5

1

0

Small-scale

0.480

High

394108

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.479

High

403303

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

449390

HXKG
Glucokinase-1

1

0

High-throughput

0.479

High

449396

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

449401

BMH1
Protein BMH1

1

0

High-throughput

0.479

High

449424

ACT
Actin

1

0

High-throughput

0.479

High

449405

BRR2
Pre-mRNA-splicing helicase BRR2

1

0

Small-scale

0.460

High

149485

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

449374

SPT2
Protein SPT2

1

0

Small-scale

0.458

High

449376

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

Small-scale

0.458

High

449379

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

449380

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

449381

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

449393

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

449398

SPT6
Transcription elongation factor SPT6

1

0

Small-scale

0.458

High

449399

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

449400

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

449403

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

449407

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

449423

SNF12
Transcription regulatory protein SNF12

1

0

Small-scale

0.458

High

449425

REG1
Resistance to glucose repression protein 1

1

0

Small-scale

0.458

High

449432

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

449392

ADT2
ADP,ATP carrier protein 2

1

1

High-throughput

0.457

High

449412

CSK2C
Casein kinase II subunit beta'

1

1

Small-scale

0.437

High

449383

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

449384

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

449388

CDC23
Anaphase-promoting complex subunit CDC23

2

0

Small-scale

0.330

High

449386

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.279

Low

449404

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.279

Low

449408

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

449409

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.279

Low

449411

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.279

Low

449413

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.279

Low

449417

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.279

Low

449421

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.279

Low

449431

NOP12
Nucleolar protein 12

1

0

High-throughput

0.279

Low

449416

FIR1
Factor interacting with REF2

1

0

Small-scale

0.261

Low

449377

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

449389

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

438177

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.251

Low

449395

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

449378

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025