Protein: UMPS
Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)]

Gene: UMPS
Organism: Homo sapiens
Interactions: 92
UniProt ID: P11172

Gene Ontology (top 5):
GO:0004588 - orotate phosphoribosyltransferase activity
GO:0004590 - orotidine-5'-phosphate decarboxylase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539027

UMPS
Uridine 5'-monophosphate synthase

1

14

Small-scale

0.692

High

539047

EPHA4
Ephrin type-A receptor 4

2

1

High-throughput

0.621

High

240586

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

539033

S10A4
Protein S100-A4

2

0

High-throughput

0.576

High

351300

EPPI
Eppin

2

1

High-throughput

0.574

High

539057

CASP8
Caspase-8

1

1

High-throughput

0.541

High

539083

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.541

High

539036

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.536

High

539055

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.536

High

539077

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

539079

SESQ1
Sesquipedalian-1

1

2

High-throughput

0.536

High

539096

CHODL
Chondrolectin

1

2

High-throughput

0.536

High

539098

KLC4
Kinesin light chain 4

1

1

High-throughput

0.536

High

539044

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.518

High

539052

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.518

High

539075

ZN227
Zinc finger protein 227

1

0

High-throughput

0.518

High

539092

PG12A
Group XIIA secretory phospholipase A2

1

0

High-throughput

0.518

High

539101

BORG2
Cdc42 effector protein 3

1

0

High-throughput

0.518

High

374364

RASH
GTPase HRas

1

0

High-throughput

0.513

High

539028

MYH6
Myosin-6

1

0

High-throughput

0.513

High

539042

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.513

High

539054

CUL3
Cullin-3

1

0

High-throughput

0.513

High

539073

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

High-throughput

0.513

High

539091

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

185384

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

539048

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

539085

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

539035

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.486

High

539046

PSN1
Presenilin-1

1

0

High-throughput

0.486

High

539072

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.486

High

362667

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

400192

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

539030

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

539034

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

539037

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

539043

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

539045

CASP4
Caspase-4

1

1

High-throughput

0.479

High

539059

EEA1
Early endosome antigen 1

1

2

High-throughput

0.479

High

539061

DUS7
Dual specificity protein phosphatase 7

1

5

High-throughput

0.479

High

539068

TENS3
Tensin-3

1

2

High-throughput

0.479

High

539070

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

2

High-throughput

0.479

High

539071

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

539084

SSH1
Protein phosphatase Slingshot homolog 1

1

5

High-throughput

0.479

High

539094

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

539095

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

539100

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

539050

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.460

High

293114

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

539039

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

539049

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

539051

VIGLN
Vigilin

1

0

High-throughput

0.458

High

539053

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

539060

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

539063

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

539066

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

539074

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

539080

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

539086

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

0

Small-scale

0.458

High

539089

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

539090

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

539099

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

429195

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

539064

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

539067

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

539041

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.438

High

539040

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

539058

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

1

High-throughput

0.437

High

539103

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

5

High-throughput

0.437

High

397884

ANGI
Angiogenin

1

0

High-throughput

0.426

High

539029

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

539078

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

539097

S17A5
Sialin

1

0

High-throughput

0.426

High

539031

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

539081

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

229634

CALU
Calumenin

1

0

High-throughput

0.282

High

539076

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

539082

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

539087

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

539088

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

369604

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.265

Low

105199

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

417917

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

539056

GIT2
ARF GTPase-activating protein GIT2

1

0

High-throughput

0.249

Low

539065

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

539069

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

262203

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.232

Low

539032

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

539038

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

539062

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.232

Low

539093

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.232

Low

539102

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025