Protein: PREP
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)

Gene: PREP, PITRM1
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q5JRX3

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006508 - proteolysis
GO:0006626 - protein targeting to mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

394875

A4
Amyloid-beta precursor protein

2

2

Small-scale

0.587

High

1127383

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

0

High-throughput

0.585

High

1086594

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

134740

CCL22
C-C motif chemokine 22

2

4

High-throughput

0.574

High

1127409

TEKT3
Tektin-3

2

2

High-throughput

0.574

High

258716

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

2

High-throughput

0.536

High

1127388

FXL19
F-box/LRR-repeat protein 19

1

2

High-throughput

0.536

High

1127419

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.536

High

1127421

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

12

High-throughput

0.536

High

716569

CAH5A
Carbonic anhydrase 5A, mitochondrial

1

1

High-throughput

0.515

High

313975

PPN
Papilin

1

0

High-throughput

0.513

High

1127394

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1127387

CGB2
Choriogonadotropin subunit beta variant 2

2

2

High-throughput

0.504

High

62667

PCARE
Photoreceptor cilium actin regulator

1

1

High-throughput

0.489

High

213957

KRT86
Keratin, type II cuticular Hb6

1

4

High-throughput

0.489

High

300312

DKK1
Dickkopf-related protein 1

1

1

High-throughput

0.489

High

331026

PAK4
Serine/threonine-protein kinase PAK 4

1

8

High-throughput

0.489

High

538756

HXB1
Homeobox protein Hox-B1

1

2

High-throughput

0.489

High

589710

ISK2
Serine protease inhibitor Kazal-type 2

1

3

High-throughput

0.489

High

678838

HXA7
Homeobox protein Hox-A7

1

2

High-throughput

0.489

High

963533

TIAR
Nucleolysin TIAR

1

1

High-throughput

0.489

High

964786

AMPD2
AMP deaminase 2

1

1

High-throughput

0.489

High

1055207

KRT81
Keratin, type II cuticular Hb1

1

4

High-throughput

0.489

High

1089426

ODAPH
Odontogenesis associated phosphoprotein

1

2

High-throughput

0.489

High

1119839

KR132
Keratin-associated protein 13-2

1

3

High-throughput

0.489

High

1127385

ISK14
Serine protease inhibitor Kazal-type 14

1

2

High-throughput

0.489

High

1127386

PRR27
Proline-rich protein 27

1

3

High-throughput

0.489

High

1127393

NAV3
Neuron navigator 3

1

1

High-throughput

0.489

High

1127422

CILK1
Serine/threonine-protein kinase ICK

1

2

High-throughput

0.489

High

135628

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

3

High-throughput

0.479

High

201641

LYRM1
LYR motif-containing protein 1

1

2

High-throughput

0.479

High

227670

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

262837

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

266727

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

2

High-throughput

0.479

High

327457

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

440552

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

12

High-throughput

0.479

High

473396

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

4

High-throughput

0.479

High

1121851

BOLA3
BolA-like protein 3

1

3

High-throughput

0.479

High

1127384

SDHF4
Succinate dehydrogenase assembly factor 4, mitochondrial

1

1

High-throughput

0.479

High

1127390

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1127392

NIT1
Deaminated glutathione amidase

1

3

High-throughput

0.479

High

1127397

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

3

High-throughput

0.479

High

1127401

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

5

High-throughput

0.479

High

1127403

COQ8B
Atypical kinase COQ8B, mitochondrial

1

9

High-throughput

0.479

High

1127406

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

1127407

DHRS4
Dehydrogenase/reductase SDR family member 4

1

4

High-throughput

0.479

High

1127413

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1127414

CQ10B
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

1

2

High-throughput

0.479

High

1127417

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

2

High-throughput

0.479

High

1127418

PAK5
Serine/threonine-protein kinase PAK 5

1

8

High-throughput

0.479

High

1127424

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

5

High-throughput

0.479

High

201120

PAX4
Paired box protein Pax-4

1

1

High-throughput

0.470

High

949116

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1127402

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

316906

KLF8
Krueppel-like factor 8

1

3

High-throughput

0.457

High

435117

SP1
Transcription factor Sp1

1

3

High-throughput

0.457

High

884176

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.457

High

1127399

SP7
Transcription factor Sp7

1

3

High-throughput

0.457

High

1127382

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1127423

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

8

High-throughput

0.445

High

119405

LEG9
Galectin-9

1

3

High-throughput

0.437

High

169091

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.437

High

552890

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

719348

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

3

High-throughput

0.437

High

779541

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

840491

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.437

High

909636

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.437

High

1035806

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.437

High

1127405

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

1127408

DUS23
Dual specificity protein phosphatase 23

1

10

High-throughput

0.437

High

1127411

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

3

High-throughput

0.437

High

1127420

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

536376

GLU2B
Glucosidase 2 subunit beta

3

0

High-throughput

0.347

High

1127400

D104A
Beta-defensin 104

2

0

High-throughput

0.328

High

49611

LNP1
Leukemia NUP98 fusion partner 1

1

0

High-throughput

0.279

Low

156837

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

1048407

NID2
Nidogen-2

1

0

High-throughput

0.279

Low

1065063

SNX17
Sorting nexin-17

1

0

High-throughput

0.279

Low

1108957

PKHG6
Pleckstrin homology domain-containing family G member 6

1

0

High-throughput

0.279

Low

1109382

KR196
Keratin-associated protein 19-6

1

0

High-throughput

0.279

Low

1127381

CI152
Uncharacterized protein C9orf152

1

0

High-throughput

0.279

Low

1127389

CEMP1
Cementoblastoma-derived protein 1

1

0

High-throughput

0.279

Low

1127391

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.279

Low

1127395

CF107
Cilia- and flagella-associated protein 107

1

0

High-throughput

0.279

Low

1127410

REG4
Regenerating islet-derived protein 4

1

0

High-throughput

0.279

Low

1127412

CFA68
Cilia- and flagella-associated protein 68

1

0

High-throughput

0.279

Low

1127415

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.279

Low

1127416

AGO4
Protein argonaute-4

1

0

High-throughput

0.279

Low

642391

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.249

Low

902840

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.249

Low

1074909

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1127396

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1127404

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1127398

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024