Protein: TIM
Protein timeless homolog (hTIM)

Gene: TIM, TIMELESS
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9UNS1

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000785 - chromatin
GO:0002009 - morphogenesis of an epithelium
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

487885

PARP1
Poly [ADP-ribose] polymerase 1

2

1

Small-scale

0.776

High

1415776

TIPIN
TIMELESS-interacting protein

9

4

Small-scale

0.753

High

756407

MCM7
DNA replication licensing factor MCM7

4

8

Small-scale

0.694

High

1065495

SSRP1
FACT complex subunit SSRP1

3

1

High-throughput

0.675

High

670038

MCM3
DNA replication licensing factor MCM3

3

10

Small-scale

0.667

High

1193578

CRY2
Cryptochrome-2

1

2

Small-scale

0.665

High

1437843

CLSPN
Claspin

3

1

Small-scale

0.664

High

1411975

PSF3
DNA replication complex GINS protein PSF3

3

0

High-throughput

0.638

High

591888

H2AX
Histone H2AX

2

1

High-throughput

0.628

High

696863

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

Small-scale

0.611

High

888391

MCM2
DNA replication licensing factor MCM2

2

8

Small-scale

0.611

High

1017301

H33
Histone H3.3

2

1

High-throughput

0.611

High

1276970

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.586

High

590032

RFA2
Replication protein A 32 kDa subunit

2

0

Small-scale

0.585

High

769513

RFA3
Replication protein A 14 kDa subunit

2

0

Small-scale

0.585

High

1360357

ATRIP
ATR-interacting protein

2

0

Small-scale

0.585

High

998945

H31
Histone H3.1

2

1

High-throughput

0.584

High

1317023

FAM9B
Protein FAM9B

2

0

High-throughput

0.576

High

920365

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.561

High

281264

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.536

High

1022990

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

961655

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.518

High

1333255

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

74644

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

388330

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

486638

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

909246

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

1323999

H2B3B
Histone H2B type 3-B

1

0

High-throughput

0.513

High

1397704

PRIPO
DNA-directed primase/polymerase protein

1

0

Small-scale

0.513

High

163193

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.493

High

182833

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

1407317

CML1
Chemerin-like receptor 1

1

1

High-throughput

0.489

High

170432

AURKA
Aurora kinase A

1

1

Small-scale

0.479

High

419272

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

756088

MCM5
DNA replication licensing factor MCM5

1

9

Small-scale

0.479

High

1116134

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

1313531

SMC5
Structural maintenance of chromosomes protein 5

1

2

Small-scale

0.479

High

1390491

DDX11
ATP-dependent DNA helicase DDX11

1

1

Small-scale

0.479

High

1391854

AURKB
Aurora kinase B

1

1

Small-scale

0.479

High

1402684

SMC6
Structural maintenance of chromosomes protein 6

1

3

Small-scale

0.479

High

218963

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

291974

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

0

Small-scale

0.458

High

316165

RECQ4
ATP-dependent DNA helicase Q4

1

0

Small-scale

0.458

High

412810

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

443558

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.458

High

465056

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

551336

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

1005247

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1029173

E2F1
Transcription factor E2F1

1

0

Small-scale

0.458

High

1100543

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1383417

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1452704

DONS
Protein downstream neighbor of Son

1

0

Small-scale

0.458

High

1453049

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1460299

XPO7
Exportin-7

1

0

High-throughput

0.458

High

914373

EFNA4
Ephrin-A4

1

1

High-throughput

0.437

High

1109532

ATR
Serine/threonine-protein kinase ATR

1

0

Small-scale

0.426

High

1309443

APLF
Aprataxin and PNK-like factor

1

0

High-throughput

0.426

High

749300

CD70
CD70 antigen

2

0

High-throughput

0.328

High

939546

FCGRN
IgG receptor FcRn large subunit p51

2

0

High-throughput

0.328

High

1293934

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

0

High-throughput

0.328

High

1351832

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

2

0

High-throughput

0.318

High

1216421

FAXC
Failed axon connections homolog

2

0

High-throughput

0.313

High

209139

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

1022504

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1101708

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1349069

TBC16
TBC1 domain family member 16

1

0

High-throughput

0.279

Low

1391531

BSCL2
Seipin

1

0

High-throughput

0.279

Low

1460831

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

390969

TRFE
Serotransferrin

1

0

High-throughput

0.251

Low

631022

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.249

Low

901681

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

1249329

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256099

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1384079

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.249

Low

1434234

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

437828

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

1366306

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025