Protein: SSK2
MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of sensor kinase 2)

Gene: SSK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 65
UniProt ID: P53599

Gene Ontology (top 5):
GO:0000131 - incipient cellular bud site
GO:0003779 - actin binding
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464623

PBS2
MAP kinase kinase PBS2

7

20

Small-scale

0.971

High

579815

HSC82
ATP-dependent molecular chaperone HSC82

3

20

High-throughput

0.830

High

921480

SLT2
Mitogen-activated protein kinase SLT2/MPK1

2

20

High-throughput

0.793

High

737917

HOG1
Mitogen-activated protein kinase HOG1

2

18

Small-scale

0.768

High

921484

SSK1
Osmolarity two-component system protein SSK1

11

4

Small-scale

0.760

High

676218

MAS5
Mitochondrial protein import protein MAS5

2

9

High-throughput

0.754

High

393107

HSP82
ATP-dependent molecular chaperone HSP82

2

20

High-throughput

0.737

High

921479

ACT
Actin

1

7

Small-scale

0.713

High

673745

SSK22
Serine/threonine-protein kinase SSK22

1

16

High-throughput

0.691

High

744006

RAD23
UV excision repair protein RAD23

1

14

High-throughput

0.665

High

921478

SSK2
MAP kinase kinase kinase SSK2

1

16

Small-scale

0.647

High

545744

SSB1
Ribosome-associated molecular chaperone SSB1

2

16

High-throughput

0.584

High

850454

LSB3
LAS seventeen-binding protein 3

1

11

High-throughput

0.541

High

757970

PRX1
Peroxiredoxin PRX1, mitochondrial

1

2

High-throughput

0.536

High

921481

UBC7
Ubiquitin-conjugating enzyme E2 7

1

5

High-throughput

0.536

High

845904

NSE4
Non-structural maintenance of chromosome element 4

2

1

High-throughput

0.516

High

636937

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.513

High

601094

RL8A
Large ribosomal subunit protein eL8A

1

2

High-throughput

0.501

High

359041

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

6

High-throughput

0.500

High

359507

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.500

High

367787

ENO1
Enolase 1

1

2

High-throughput

0.500

High

405119

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.500

High

439387

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.500

High

592402

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.500

High

597226

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.500

High

644818

CLH
Clathrin heavy chain

1

2

High-throughput

0.500

High

701726

URA7
CTP synthase 1

1

1

High-throughput

0.500

High

806253

RGD3
Rho-GTPase-activating protein RGD3

1

0

High-throughput

0.480

High

864791

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.480

High

408334

GAL1
Galactokinase

1

0

High-throughput

0.479

High

454121

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.479

High

654735

SPA2
Protein SPA2

1

8

Small-scale

0.479

High

747968

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

921486

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

815005

SLN1
Osmosensing histidine protein kinase SLN1

1

0

High-throughput

0.460

High

581931

CATA
Peroxisomal catalase A

1

2

High-throughput

0.457

High

609234

CLC1
Clathrin light chain

1

1

High-throughput

0.457

High

849829

BUD27
Bud site selection protein 27

1

1

High-throughput

0.457

High

916834

MALX3
Oligo-1,6-glucosidase IMA1

1

1

High-throughput

0.457

High

456435

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.457

High

590687

HSP26
Heat shock protein 26

1

1

High-throughput

0.457

High

661670

MPCP
Mitochondrial phosphate carrier protein

1

5

High-throughput

0.457

High

709897

BMH1
Protein BMH1

1

13

High-throughput

0.457

High

760311

BMH2
Protein BMH2

1

13

High-throughput

0.457

High

921487

HSP42
Heat shock protein 42

1

1

High-throughput

0.457

High

510693

HSP77
Import motor subunit, mitochondrial

1

16

High-throughput

0.445

High

524704

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

527303

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

742083

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

707776

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

877870

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

863676

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

448202

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.279

Low

605915

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.279

Low

745488

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.279

Low

921485

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.279

Low

642063

DPOE
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.261

Low

776702

ASK1
DASH complex subunit ASK1

1

0

High-throughput

0.261

Low

820884

SIP5
Protein SIP5

1

0

High-throughput

0.261

Low

921482

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.261

Low

921483

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.261

Low

834714

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.261

Low

856552

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

745166

CACP
Carnitine O-acetyltransferase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025