Protein: MED17
Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (Suppressor of RNA polymerase B 4)

Gene: MED17, SRB4
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P32569

Gene Ontology (top 5):
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001139 - RNA polymerase II complex recruiting activity
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740398

MED8
Mediator of RNA polymerase II transcription subunit 8

17

2

Small-scale

0.987

High

740437

MED7
Mediator of RNA polymerase II transcription subunit 7

13

2

Small-scale

0.978

High

740386

MED18
Mediator of RNA polymerase II transcription subunit 18

23

0

Small-scale

0.939

High

740403

MED6
Mediator of RNA polymerase II transcription subunit 6

20

0

Small-scale

0.938

High

740385

MED22
Mediator of RNA polymerase II transcription subunit 22

21

0

Small-scale

0.938

High

740394

MED20
Mediator of RNA polymerase II transcription subunit 20

18

0

Small-scale

0.935

High

740446

MED11
Mediator of RNA polymerase II transcription subunit 11

15

0

Small-scale

0.934

High

619406

MED14
Mediator of RNA polymerase II transcription subunit 14

12

0

Small-scale

0.925

High

740444

MED4
Mediator of RNA polymerase II transcription subunit 4

10

0

Small-scale

0.921

High

740401

MED31
Mediator of RNA polymerase II transcription subunit 31

6

0

Small-scale

0.889

High

401932

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

0

Small-scale

0.878

High

740384

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.736

High

624879

MED15
Mediator of RNA polymerase II transcription subunit 15

10

0

Small-scale

0.717

High

740391

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.717

High

632069

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

Small-scale

0.716

High

740439

MED2
Mediator of RNA polymerase II transcription subunit 2

9

0

Small-scale

0.715

High

733524

MED16
Mediator of RNA polymerase II transcription subunit 16

8

0

Small-scale

0.714

High

740422

MED21
Mediator of RNA polymerase II transcription subunit 21

7

0

Small-scale

0.713

High

668472

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.712

High

740413

MED3
Mediator of RNA polymerase II transcription subunit 3

8

0

Small-scale

0.712

High

740423

MED5
Mediator of RNA polymerase II transcription subunit 5

7

0

Small-scale

0.710

High

740442

MED1
Mediator of RNA polymerase II transcription subunit 1

7

0

Small-scale

0.710

High

740406

SSN2
Mediator of RNA polymerase II transcription subunit 13

6

0

Small-scale

0.699

High

740407

SSN3
Meiotic mRNA stability protein kinase SSN3

6

0

Small-scale

0.698

High

408397

GAL4
Regulatory protein GAL4

5

0

Small-scale

0.691

High

740434

MED10
Mediator of RNA polymerase II transcription subunit 10

4

0

Small-scale

0.657

High

594262

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

Small-scale

0.643

High

740395

TAF14
Transcription initiation factor TFIID subunit 14

4

0

Small-scale

0.638

High

740417

T2FB
Transcription initiation factor IIF subunit beta

3

0

Small-scale

0.606

High

740416

T2FA
Transcription initiation factor IIF subunit alpha

3

0

Small-scale

0.597

High

454653

RAD2
DNA repair protein RAD2

2

0

Small-scale

0.593

High

561441

TBP
TATA-box-binding protein

2

0

Small-scale

0.577

High

740393

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

Small-scale

0.577

High

740419

RSC8
Chromatin structure-remodeling complex protein RSC8

2

1

Small-scale

0.576

High

481539

HSP73
Heat shock protein SSA3

2

2

Small-scale

0.571

High

395230

GCN4
General control transcription factor GCN4

2

0

Small-scale

0.559

High

678799

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

Small-scale

0.559

High

526206

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

740405

RPB11
DNA-directed RNA polymerase II subunit RPB11

2

0

Small-scale

0.547

High

740441

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

544205

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.536

High

626481

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.518

High

678827

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.518

High

740428

CAF40
Protein CAF40

1

0

High-throughput

0.518

High

704580

SBA1
Co-chaperone protein SBA1

1

0

High-throughput

0.486

High

466783

SWI5
Transcriptional factor SWI5

1

0

Small-scale

0.480

High

734397

BTAF1
TATA-binding protein-associated factor MOT1

1

2

Small-scale

0.479

High

740388

SWI3
SWI/SNF complex subunit SWI3

1

1

Small-scale

0.479

High

740412

RAD26
DNA repair and recombination protein RAD26

1

2

Small-scale

0.479

High

740421

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

1

High-throughput

0.479

High

448370

RAD1
DNA repair protein RAD1

1

0

Small-scale

0.458

High

449284

RAD10
DNA repair protein RAD10

1

0

Small-scale

0.458

High

483758

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

Small-scale

0.458

High

614808

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

Small-scale

0.458

High

617780

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

643616

SNF2
Transcription regulatory protein SNF2

1

0

Small-scale

0.458

High

706538

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

740389

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

740396

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

740400

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

740418

SWP82
SWI/SNF global transcription activator complex subunit SWP82

1

0

Small-scale

0.458

High

740424

RT102
Regulator of Ty1 transposition protein 102

1

0

Small-scale

0.458

High

740425

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

Small-scale

0.458

High

740426

SNF12
Transcription regulatory protein SNF12

1

0

Small-scale

0.458

High

740430

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

740431

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

740432

ARP9
Actin-like protein ARP9

1

0

Small-scale

0.458

High

740436

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

Small-scale

0.458

High

740440

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

740445

ARP7
Actin-related protein 7

1

0

Small-scale

0.458

High

523391

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

740387

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

740404

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

740411

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

381021

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

470490

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.426

High

632145

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

Small-scale

0.426

High

632242

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.426

High

632324

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.426

High

645038

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

Small-scale

0.426

High

699939

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.426

High

740392

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

740414

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.426

High

740429

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

Small-scale

0.426

High

740438

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.426

High

740397

LHS1
Heat shock protein 70 homolog LHS1

1

3

High-throughput

0.407

High

740399

ARPC1
Actin-related protein 2/3 complex subunit 1

2

0

Small-scale

0.300

High

713216

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.269

Low

740402

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.269

Low

470637

ERG20
Farnesyl pyrophosphate synthase

1

0

Small-scale

0.251

Low

671444

RNA15
mRNA 3'-end-processing protein RNA15

1

0

Small-scale

0.249

Low

736071

ARP2
Actin-related protein 2

1

0

Small-scale

0.249

Low

740390

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.249

Low

740415

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.249

Low

740420

ARP3
Actin-related protein 3

1

0

Small-scale

0.249

Low

740427

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

740433

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.249

Low

740435

CORO
Coronin-like protein

1

0

Small-scale

0.249

Low

739320

ZUO1
Zuotin

1

0

High-throughput

0.232

Low

740408

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.232

Low

740409

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

740410

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low

740443

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025