Protein: MED22
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Suppressor of RNA polymerase B 6)

Gene: MED22, SRB6
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P32570

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740385

MED17
Mediator of RNA polymerase II transcription subunit 17

21

0

Small-scale

0.938

High

740483

MED11
Mediator of RNA polymerase II transcription subunit 11

9

0

Small-scale

0.927

High

740447

MED18
Mediator of RNA polymerase II transcription subunit 18

9

0

Small-scale

0.919

High

740454

MED8
Mediator of RNA polymerase II transcription subunit 8

8

0

Small-scale

0.914

High

740456

MED6
Mediator of RNA polymerase II transcription subunit 6

5

0

Small-scale

0.872

High

740476

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.708

High

624880

MED15
Mediator of RNA polymerase II transcription subunit 15

6

0

Small-scale

0.697

High

619407

MED14
Mediator of RNA polymerase II transcription subunit 14

6

0

Small-scale

0.696

High

740449

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.696

High

740451

MED20
Mediator of RNA polymerase II transcription subunit 20

5

0

Small-scale

0.682

High

740462

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.682

High

740466

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

Small-scale

0.682

High

740474

MED10
Mediator of RNA polymerase II transcription subunit 10

5

0

Small-scale

0.682

High

740480

MED1
Mediator of RNA polymerase II transcription subunit 1

5

0

Small-scale

0.682

High

740481

MED4
Mediator of RNA polymerase II transcription subunit 4

5

0

Small-scale

0.682

High

740469

MED5
Mediator of RNA polymerase II transcription subunit 5

5

0

Small-scale

0.679

High

401933

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

0

Small-scale

0.676

High

733525

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

Small-scale

0.658

High

740455

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

Small-scale

0.644

High

740479

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

Small-scale

0.644

High

740457

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

High-throughput

0.634

High

740458

SSN3
Meiotic mRNA stability protein kinase SSN3

3

0

High-throughput

0.634

High

740452

SPT7
SAGA complex subunit SPT7

2

1

High-throughput

0.621

High

668473

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

Small-scale

0.616

High

626482

AP1
AP-1-like transcription factor YAP1

2

0

High-throughput

0.595

High

678800

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

High-throughput

0.595

High

740470

ADA2
SAGA complex subunit ADA2

2

0

High-throughput

0.595

High

740472

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.595

High

740463

T2FB
Transcription initiation factor IIF subunit beta

2

0

Small-scale

0.569

High

740465

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

0

High-throughput

0.563

High

740468

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

0

High-throughput

0.563

High

706539

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.559

High

544206

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

448678

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.518

High

408398

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.458

High

740453

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

740478

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

740482

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

523392

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526207

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

740448

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

740461

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

403416

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

444462

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.426

High

531657

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

740471

MLP1
Protein MLP1

2

0

High-throughput

0.324

High

569737

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

570227

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.279

Low

601003

RL8A
Large ribosomal subunit protein eL8A

1

0

High-throughput

0.279

Low

740459

RS14B
Small ribosomal subunit protein uS11B

1

0

High-throughput

0.279

Low

740464

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.279

Low

740460

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

740475

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

394367

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

410009

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

453487

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

502925

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.232

Low

510314

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

592110

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

740450

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

740467

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

740473

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.232

Low

740477

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025