Protein: MED18
Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (Suppressor of RNA polymerase B 5)

Gene: MED18, SRB5
Organism: Saccharomyces cerevisiae S288C
Interactions: 87
UniProt ID: P32585

Gene Ontology (top 5):
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001113 - transcription open complex formation at RNA polymerase II promoter
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740791

MED8
Mediator of RNA polymerase II transcription subunit 8

20

1

Small-scale

0.987

High

740386

MED17
Mediator of RNA polymerase II transcription subunit 17

23

0

Small-scale

0.939

High

740787

MED20
Mediator of RNA polymerase II transcription subunit 20

14

0

Small-scale

0.933

High

740447

MED22
Mediator of RNA polymerase II transcription subunit 22

9

0

Small-scale

0.919

High

740824

MED11
Mediator of RNA polymerase II transcription subunit 11

8

0

Small-scale

0.915

High

401934

RPB1
DNA-directed RNA polymerase II subunit RPB1

8

0

Small-scale

0.907

High

740816

MED7
Mediator of RNA polymerase II transcription subunit 7

16

1

Small-scale

0.761

High

624881

MED15
Mediator of RNA polymerase II transcription subunit 15

15

0

Small-scale

0.727

High

619408

MED14
Mediator of RNA polymerase II transcription subunit 14

14

0

Small-scale

0.727

High

740818

MED2
Mediator of RNA polymerase II transcription subunit 2

13

0

Small-scale

0.724

High

740819

MED1
Mediator of RNA polymerase II transcription subunit 1

12

0

Small-scale

0.724

High

740809

MED5
Mediator of RNA polymerase II transcription subunit 5

10

0

Small-scale

0.722

High

733526

MED16
Mediator of RNA polymerase II transcription subunit 16

9

0

Small-scale

0.720

High

740801

MED3
Mediator of RNA polymerase II transcription subunit 3

10

0

Small-scale

0.720

High

740794

MED6
Mediator of RNA polymerase II transcription subunit 6

10

0

Small-scale

0.720

High

740820

MED4
Mediator of RNA polymerase II transcription subunit 4

9

0

Small-scale

0.717

High

668474

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.714

High

740784

MED9
Mediator of RNA polymerase II transcription subunit 9

8

0

Small-scale

0.714

High

740814

MED10
Mediator of RNA polymerase II transcription subunit 10

6

0

Small-scale

0.697

High

740793

MED31
Mediator of RNA polymerase II transcription subunit 31

6

0

Small-scale

0.696

High

740797

SSN3
Meiotic mRNA stability protein kinase SSN3

5

0

Small-scale

0.690

High

740796

SSN2
Mediator of RNA polymerase II transcription subunit 13

5

0

Small-scale

0.678

High

740808

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

Small-scale

0.678

High

740804

T2FB
Transcription initiation factor IIF subunit beta

4

0

Small-scale

0.651

High

740781

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.631

High

594264

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

Small-scale

0.628

High

678801

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

Small-scale

0.613

High

740807

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

0

Small-scale

0.595

High

726861

HS104
Heat shock protein 104

2

1

High-throughput

0.588

High

740800

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.588

High

561442

TBP
TATA-box-binding protein

2

0

Small-scale

0.585

High

706546

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.585

High

381965

H4
Histone H4

2

0

Small-scale

0.577

High

579062

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

740792

PAF1
RNA polymerase II-associated protein 1

2

0

Small-scale

0.559

High

740815

CDC73
Cell division control protein 73

2

0

Small-scale

0.559

High

523397

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.552

High

470492

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

Small-scale

0.547

High

679499

CDC48
Cell division control protein 48

1

0

High-throughput

0.493

High

740798

HAT2
Histone acetyltransferase type B subunit 2

1

0

High-throughput

0.493

High

740806

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.493

High

740821

ARP8
Actin-like protein ARP8

1

0

High-throughput

0.493

High

547775

NHP6A
Non-histone chromosomal protein 6A

1

1

Small-scale

0.481

High

547858

NHP6B
Non-histone chromosomal protein 6B

1

1

Small-scale

0.481

High

381022

H2B1
Histone H2B.1

1

0

Small-scale

0.480

High

740810

H3
Histone H3

1

0

Small-scale

0.480

High

481542

HSP73
Heat shock protein SSA3

1

2

Small-scale

0.479

High

408399

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.458

High

598384

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.458

High

632070

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

632146

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

Small-scale

0.458

High

632243

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.458

High

632325

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.458

High

671406

RNA14
mRNA 3'-end-processing protein RNA14

1

0

Small-scale

0.458

High

699940

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.458

High

734398

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.458

High

740788

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

740789

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

740795

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

Small-scale

0.458

High

740803

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.458

High

740811

IMA1
Importin subunit alpha

1

0

High-throughput

0.458

High

740813

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

392435

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

526212

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544213

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

740782

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

740783

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

740786

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

597081

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

670488

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

510318

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

740799

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

740812

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

5

High-throughput

0.407

High

394371

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.313

High

427188

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.279

Low

740790

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

Small-scale

0.279

Low

740785

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.269

Low

740805

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.269

Low

740822

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.251

Low

533490

TIR1
Cold shock-induced protein TIR1

1

0

High-throughput

0.249

Low

639549

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.249

Low

671445

RNA15
mRNA 3'-end-processing protein RNA15

1

0

Small-scale

0.249

Low

740823

IRC11
Putative increased recombination centers protein 11

1

0

High-throughput

0.249

Low

475113

CYAA
Adenylate cyclase

1

0

Small-scale

0.232

Low

740802

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

740817

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025