Protein: MED20
Mediator of RNA polymerase II transcription subunit 20 (Hyper-recombination suppressor protein 2) (Mediator complex subunit 20) (Suppressor of RNA polymerase B 2)

Gene: MED20, SRB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P34162

Gene Ontology (top 5):
GO:0001094 - TFIID-class transcription factor complex binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0010688 - negative regulation of ribosomal protein gene transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740394

MED17
Mediator of RNA polymerase II transcription subunit 17

18

0

Small-scale

0.935

High

740787

MED18
Mediator of RNA polymerase II transcription subunit 18

14

0

Small-scale

0.933

High

757579

MED8
Mediator of RNA polymerase II transcription subunit 8

9

0

Small-scale

0.715

High

619415

MED14
Mediator of RNA polymerase II transcription subunit 14

7

0

Small-scale

0.709

High

594296

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.699

High

624891

MED15
Mediator of RNA polymerase II transcription subunit 15

6

0

Small-scale

0.696

High

757596

MED7
Mediator of RNA polymerase II transcription subunit 7

6

0

Small-scale

0.696

High

740451

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

757599

MED2
Mediator of RNA polymerase II transcription subunit 2

5

0

Small-scale

0.676

High

757590

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.657

High

757581

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.638

High

751199

MED9
Mediator of RNA polymerase II transcription subunit 9

3

0

Small-scale

0.622

High

668478

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.616

High

757580

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

High-throughput

0.616

High

395233

GCN4
General control transcription factor GCN4

3

0

Small-scale

0.613

High

757586

MED3
Mediator of RNA polymerase II transcription subunit 3

3

0

Small-scale

0.597

High

733531

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

757601

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.585

High

561457

TBP
TATA-box-binding protein

2

0

Small-scale

0.576

High

757576

DEF1
RNA polymerase II degradation factor 1

2

0

High-throughput

0.576

High

757595

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.576

High

757603

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.576

High

757604

MED11
Mediator of RNA polymerase II transcription subunit 11

2

0

High-throughput

0.576

High

757588

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

0

Small-scale

0.569

High

757578

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

2

0

Small-scale

0.563

High

757602

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.563

High

381053

H2B1
Histone H2B.1

2

0

Small-scale

0.560

High

757587

T2FB
Transcription initiation factor IIF subunit beta

2

0

Small-scale

0.559

High

706688

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.547

High

626489

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

757594

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.513

High

672865

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.493

High

738143

NGG1
SAGA complex subunit NGG1

1

0

Small-scale

0.493

High

757585

HAT2
Histone acetyltransferase type B subunit 2

1

0

High-throughput

0.493

High

757597

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

0

High-throughput

0.493

High

382006

H4
Histone H4

1

0

Small-scale

0.480

High

401954

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.480

High

408405

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.458

High

757575

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

757582

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.458

High

757583

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.458

High

757589

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

757592

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

757600

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

481575

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

523521

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526321

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544356

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

757591

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

440835

KIN28
Serine/threonine-protein kinase KIN28

1

0

Small-scale

0.426

High

757577

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.426

High

757584

LAA1
AP-1 accessory protein LAA1

2

0

High-throughput

0.305

High

757593

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low

631887

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low

757598

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025