Protein: ESC1
Silent chromatin protein ESC1 (Establishes silent chromatin protein 1)

Gene: ESC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 122
UniProt ID: Q03661

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0031509 - subtelomeric heterochromatin formation
GO:0034398 - telomere tethering at nuclear periphery
GO:0034399 - nuclear periphery

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550688

SIR4
Regulatory protein SIR4

6

0

Small-scale

0.703

High

850182

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

2

High-throughput

0.585

High

824780

MLP2
Protein MLP2

2

5

High-throughput

0.584

High

1043575

SMT3
Ubiquitin-like protein SMT3

2

2

High-throughput

0.548

High

740216

RPN2
26S proteasome regulatory subunit RPN2

2

3

High-throughput

0.533

High

750770

PRS6A
26S proteasome regulatory subunit 6A

2

3

High-throughput

0.533

High

750889

PRS6B
26S proteasome regulatory subunit 6B homolog

2

5

High-throughput

0.533

High

751000

PRS7
26S proteasome regulatory subunit 7 homolog

2

6

High-throughput

0.533

High

803671

RPN1
26S proteasome regulatory subunit RPN1

2

3

High-throughput

0.533

High

806809

RPN10
26S proteasome regulatory subunit RPN10

2

1

High-throughput

0.533

High

921098

PRS10
26S proteasome subunit RPT4

2

7

High-throughput

0.533

High

1033878

PRS8
26S proteasome regulatory subunit 8 homolog

2

5

High-throughput

0.533

High

1043568

RPN7
26S proteasome regulatory subunit RPN7

2

1

High-throughput

0.533

High

1043574

RPN5
26S proteasome regulatory subunit RPN5

2

1

High-throughput

0.533

High

393252

HSP82
ATP-dependent molecular chaperone HSP82

2

5

High-throughput

0.521

High

524997

HSP71
Heat shock protein SSA1

2

11

High-throughput

0.521

High

527557

HSP72
Heat shock protein SSA2

2

11

High-throughput

0.521

High

546094

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.521

High

671066

SIS1
Protein SIS1

2

6

High-throughput

0.521

High

577341

NSP1
Nucleoporin NSP1

1

1

High-throughput

0.479

High

1036916

MLP1
Protein MLP1

1

5

High-throughput

0.479

High

665852

KPC1
Protein kinase C-like 1

1

3

High-throughput

0.470

High

444870

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.458

High

603101

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

795187

NU170
Nucleoporin NUP170

1

0

Small-scale

0.458

High

813653

NUP60
Nucleoporin NUP60

1

0

Small-scale

0.458

High

727286

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

557761

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.439

High

359338

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.437

High

368045

ENO2
Enolase 2

1

2

High-throughput

0.437

High

394860

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.437

High

427425

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.437

High

435328

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

436146

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

439415

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.437

High

444613

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.437

High

453344

CARA
Carbamoyl phosphate synthase arginine-specific small chain

1

1

High-throughput

0.437

High

504638

YP12B
Transposon Ty1-PR1 Gag-Pol polyprotein

1

1

High-throughput

0.437

High

512146

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.437

High

531869

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.437

High

554959

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

570298

RS17B
Small ribosomal subunit protein eS17B

1

1

High-throughput

0.437

High

579979

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.437

High

655511

RS3A2
Small ribosomal subunit protein eS1B

1

1

High-throughput

0.437

High

680017

CDC48
Cell division control protein 48

1

3

High-throughput

0.437

High

708042

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

736042

SP110
Spindle pole body component 110

1

8

High-throughput

0.437

High

737489

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.437

High

744015

RAD23
UV excision repair protein RAD23

1

1

High-throughput

0.437

High

747555

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

792222

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

802366

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

803165

ECM29
Proteasome component ECM29

1

1

High-throughput

0.437

High

822431

PRS4
26S proteasome regulatory subunit 4 homolog

1

6

High-throughput

0.437

High

826169

SCC3
Cohesin subunit SCC3

1

4

High-throughput

0.437

High

850344

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

2

High-throughput

0.437

High

858057

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.437

High

893073

PSD10
Probable 26S proteasome regulatory subunit p28

1

4

High-throughput

0.437

High

916797

ROM1
RHO1 GDP-GTP exchange protein 1

1

2

High-throughput

0.437

High

918104

RPN14
26S proteasome regulatory subunit RPN14

1

5

High-throughput

0.437

High

948640

ACT
Actin

1

3

High-throughput

0.437

High

1025169

SEN1
Helicase SEN1

1

2

High-throughput

0.437

High

1043566

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.437

High

1043569

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

1043571

PMG2
Phosphoglycerate mutase 2

1

1

High-throughput

0.437

High

1043572

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.437

High

1043573

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

Small-scale

0.437

High

818192

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.426

High

481746

HSP73
Heat shock protein SSA3

1

11

High-throughput

0.407

High

816376

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.407

High

826480

DJP1
DnaJ-like protein 1

1

3

High-throughput

0.407

High

1043576

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

738335

RPN12
26S proteasome regulatory subunit RPN12

2

0

High-throughput

0.305

High

817084

RPN3
26S proteasome regulatory subunit RPN3

2

0

High-throughput

0.305

High

1043564

RPN9
26S proteasome regulatory subunit RPN9

2

0

High-throughput

0.305

High

1043570

RPN8
26S proteasome regulatory subunit RPN8

2

0

High-throughput

0.305

High

1043577

RPN6
26S proteasome regulatory subunit RPN6

2

0

High-throughput

0.305

High

655634

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.269

Low

734278

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.261

Low

849843

BUD27
Bud site selection protein 27

1

0

Small-scale

0.251

Low

1043563

GIS1
Transcriptional activator/repressor GIS1

1

0

Small-scale

0.251

Low

150306

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.249

Low

314906

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.249

Low

358322

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.249

Low

365172

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.249

Low

420981

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.249

Low

432360

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.249

Low

442090

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

482086

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.249

Low

503951

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.249

Low

511277

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511848

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

514810

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

572643

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.249

Low

582253

AMPD
AMP deaminase

1

0

High-throughput

0.249

Low

594995

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

597547

EF3A
Elongation factor 3A

1

0

High-throughput

0.249

Low

613627

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.249

Low

642160

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

646521

RAD53
Serine/threonine-protein kinase RAD53

1

0

Small-scale

0.249

Low

661557

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

661684

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

684828

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.249

Low

689639

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

693520

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.249

Low

734723

IMB3
Importin subunit beta-3

1

0

High-throughput

0.249

Low

735665

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.249

Low

738914

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

746306

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.249

Low

760622

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.249

Low

790225

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.249

Low

792371

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.249

Low

803433

RL14B
Large ribosomal subunit protein eL14B

1

0

High-throughput

0.249

Low

825018

TAO3
Cell morphogenesis protein PAG1

1

0

High-throughput

0.249

Low

864646

NU192
Nucleoporin NUP192

1

0

High-throughput

0.249

Low

865735

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

916980

EDC1
Enhancer of mRNA-decapping protein 1

1

0

High-throughput

0.249

Low

924268

PBR1
Uncharacterized oxidoreductase YNL181W

1

0

High-throughput

0.249

Low

1036285

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.249

Low

1043562

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.249

Low

1043565

UBX2
UBX domain-containing protein 2

1

0

High-throughput

0.249

Low

1043567

VID22
Vacuolar import and degradation protein 22

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025