Protein: FCF2
rRNA-processing protein FCF2 (FAF1 copurifying factor 2)

Gene: FCF2
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: Q12035

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798348

ENP1
Essential nuclear protein 1

3

0

High-throughput

0.613

High

1046082

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.613

High

826227

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

678481

PWP2
Periodic tryptophan protein 2

2

2

Small-scale

0.584

High

844656

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

1053533

UTP21
U3 small nucleolar RNA-associated protein 21

2

2

Small-scale

0.584

High

1084167

NOP58
Nucleolar protein 58

2

2

High-throughput

0.584

High

677609

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

923998

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

1046821

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

1055515

NOC4
Nucleolar complex protein 4

2

0

High-throughput

0.559

High

503293

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.533

High

745539

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.493

High

149999

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

435425

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

512707

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

747061

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

2

High-throughput

0.479

High

747626

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

754352

DCA13
Protein SOF1

1

1

High-throughput

0.479

High

792299

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

804764

RRP4
Exosome complex component RRP4

1

1

High-throughput

0.479

High

817652

UTP7
U3 small nucleolar RNA-associated protein 7

1

1

High-throughput

0.479

High

863150

RRP41
Exosome complex component SKI6

1

3

High-throughput

0.479

High

918909

RRP46
Exosome complex component RRP46

1

3

High-throughput

0.479

High

923267

ESF2
Pre-rRNA-processing protein ESF2

1

1

High-throughput

0.479

High

924867

NOP15
Ribosome biogenesis protein 15

1

1

High-throughput

0.479

High

1039873

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

1042262

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

1045123

UTP5
U3 small nucleolar RNA-associated protein 5

1

2

High-throughput

0.479

High

1046273

UTP15
U3 small nucleolar RNA-associated protein 15

1

1

High-throughput

0.479

High

1051173

FCF1
rRNA-processing protein FCF1

1

1

High-throughput

0.479

High

1051723

RRP45
Exosome complex component RRP45

1

3

High-throughput

0.479

High

1053130

UTP13
U3 small nucleolar RNA-associated protein 13

1

3

High-throughput

0.479

High

1055444

RRP9
Ribosomal RNA-processing protein 9

1

1

High-throughput

0.479

High

1056495

UTP4
U3 small nucleolar RNA-associated protein 4

1

2

High-throughput

0.479

High

1061955

RRP44
Exosome complex exonuclease DIS3

1

1

High-throughput

0.479

High

1084161

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

1084163

UTP12
U3 small nucleolar RNA-associated protein 12

1

2

High-throughput

0.479

High

1084164

RRP42
Exosome complex component RRP42

1

3

High-throughput

0.479

High

1084165

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

436220

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442160

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

514879

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

632759

DBP4
ATP-dependent RNA helicase HCA4

1

0

High-throughput

0.458

High

672976

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673248

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

674886

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689713

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

708464

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

758424

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

763648

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

782118

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

804972

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

806595

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

808326

RRP8
25S rRNA

1

0

High-throughput

0.458

High

808930

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

818358

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

823407

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

825096

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825574

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

826916

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

836212

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

852623

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

864548

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.458

High

864980

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

865190

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

High-throughput

0.458

High

871074

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

871139

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

918850

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.458

High

919192

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

924658

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

925216

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.458

High

1036428

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

1050202

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.458

High

1054553

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

1054906

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

1056324

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

1061643

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1062917

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1064280

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1064327

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1065594

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

1084160

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

1084162

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1084166

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

1084168

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

1084170

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

1084171

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

782482

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.445

High

1064818

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

1084169

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.437

High

836035

COPB
Coatomer subunit beta

1

0

High-throughput

0.269

Low

383938

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

455308

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

513275

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

753642

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778581

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

785994

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.249

Low

802437

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

874581

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

1033621

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1059402

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

528880

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.238

Low

1035184

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025