Protein: UBP30
Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30)

Gene: UBP30, USP30
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q70CQ3

Gene Ontology (top 5):
GO:0000422 - autophagy of mitochondrion
GO:0000425 - pexophagy
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508177

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

20

Small-scale

0.919

High

1258009

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.770

High

507245

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.734

High

580792

PVR
Poliovirus receptor

2

3

High-throughput

0.726

High

1149103

SF3A1
Splicing factor 3A subunit 1

1

4

High-throughput

0.691

High

1147623

TOM20
Mitochondrial import receptor subunit TOM20 homolog

4

1

Small-scale

0.676

High

1137632

EXOS7
Exosome complex component RRP42

3

6

High-throughput

0.667

High

242081

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

1258012

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

2

1

High-throughput

0.628

High

388721

C1QB
Complement C1q subcomponent subunit B

3

3

High-throughput

0.609

High

348581

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

3

High-throughput

0.584

High

192104

PA2GX
Group 10 secretory phospholipase A2

2

6

High-throughput

0.574

High

1245243

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

2

5

High-throughput

0.574

High

1258000

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.574

High

1258017

PCDGD
Protocadherin gamma-B1

2

3

High-throughput

0.574

High

396382

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

1258010

MTCH1
Mitochondrial carrier homolog 1

2

6

High-throughput

0.571

High

1258018

MTCH2
Mitochondrial carrier homolog 2

2

6

High-throughput

0.571

High

1258004

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

Small-scale

0.559

High

1258008

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

Small-scale

0.559

High

1238163

RHBD2
Rhomboid domain-containing protein 2

2

1

High-throughput

0.553

High

274014

CREST
Calcium-responsive transactivator

1

1

High-throughput

0.536

High

848510

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.536

High

1257969

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1257993

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.536

High

927372

ATX1
Ataxin-1

1

3

High-throughput

0.515

High

238718

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.513

High

303685

JTB
Protein JTB

1

0

High-throughput

0.513

High

1257986

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.513

High

646870

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.501

High

190408

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

388645

C1QA
Complement C1q subcomponent subunit A

1

3

High-throughput

0.489

High

388784

C1QC
Complement C1q subcomponent subunit C

1

3

High-throughput

0.489

High

956918

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.489

High

1153471

EFNB3
Ephrin-B3

1

2

High-throughput

0.489

High

1213626

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

6

High-throughput

0.489

High

1257971

IFT20
Intraflagellar transport protein 20 homolog

1

1

High-throughput

0.489

High

1257975

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

8

High-throughput

0.489

High

1257976

CLC2B
C-type lectin domain family 2 member B

1

1

High-throughput

0.489

High

1258016

PCDBB
Protocadherin beta-11

1

3

High-throughput

0.489

High

926096

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.480

High

216729

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

245487

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.479

High

281608

MTX2
Metaxin-2

1

2

High-throughput

0.479

High

318023

TOM70
Mitochondrial import receptor subunit TOM70

1

5

Small-scale

0.479

High

354354

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

6

Small-scale

0.479

High

372380

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

611188

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

4

High-throughput

0.479

High

668640

APC
Adenomatous polyposis coli protein

1

14

Small-scale

0.479

High

764851

CTNB1
Catenin beta-1

1

15

Small-scale

0.479

High

1060097

BAX
Apoptosis regulator BAX

1

3

Small-scale

0.479

High

1113493

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1125501

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.479

High

1178216

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1207053

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1257968

MAVS
Mitochondrial antiviral-signaling protein

1

11

High-throughput

0.479

High

1257970

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.479

High

1257972

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.479

High

1257973

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.479

High

1257974

MPND
MPN domain-containing protein

1

2

High-throughput

0.479

High

1257977

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1257978

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1257984

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1257985

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

2

Small-scale

0.479

High

1257987

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1257989

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

1257990

PHB2
Prohibitin-2

1

3

High-throughput

0.479

High

1257994

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

1257997

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

1258001

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1258005

DDX28
Probable ATP-dependent RNA helicase DDX28

1

20

High-throughput

0.479

High

1258006

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

5

High-throughput

0.479

High

124385

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

166940

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

941918

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1013410

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1149584

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1214511

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1257981

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1257982

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

1257983

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1257988

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

1257991

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1258002

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1258003

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1258007

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1258014

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1258015

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

293905

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

650250

FGFR3
Fibroblast growth factor receptor 3

1

17

High-throughput

0.437

High

900881

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.437

High

1257995

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1257998

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.437

High

166331

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

4

High-throughput

0.407

High

1240880

S27A4
Long-chain fatty acid transport protein 4

1

4

High-throughput

0.407

High

1243615

S27A1
Long-chain fatty acid transport protein 1

1

4

High-throughput

0.407

High

1251143

ZNT10
Calcium/manganese antiporter SLC30A10

1

4

High-throughput

0.407

High

1258013

S27A5
Long-chain fatty acid transport protein 5

1

4

High-throughput

0.407

High

1258019

W4VSR2
MPN domain-containing protein

1

2

High-throughput

0.407

High

1257999

SG196
Protein O-mannose kinase

3

0

High-throughput

0.347

High

720618

GRPR
Gastrin-releasing peptide receptor

2

0

High-throughput

0.328

High

1198009

RFTN2
Raftlin-2

2

0

High-throughput

0.328

High

1257979

EXT2
Exostosin-2

2

0

High-throughput

0.328

High

1257980

P2RX5
P2X purinoceptor 5

2

0

High-throughput

0.328

High

230706

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

317728

NOL4
Nucleolar protein 4

1

0

High-throughput

0.279

Low

549809

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

1198715

MPPE1
Metallophosphoesterase 1

1

0

High-throughput

0.279

Low

1248505

C16L2
CD164 sialomucin-like 2 protein

1

0

High-throughput

0.279

Low

1257996

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1258011

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

377622

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1257992

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025