Protein: EDA
Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]

Gene: EDA
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q92838

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005123 - death receptor binding
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding
GO:0005581 - collagen trimer

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688405

PPLA
Phospholamban

6

0

High-throughput

0.710

High

932745

EMP3
Epithelial membrane protein 3

4

2

High-throughput

0.698

High

126160

AP3B1
AP-3 complex subunit beta-1

4

2

High-throughput

0.691

High

1308824

P3H2
Prolyl 3-hydroxylase 2

4

9

High-throughput

0.691

High

1242188

NPAL3
NIPA-like protein 3

5

0

High-throughput

0.685

High

329649

LERL1
Leptin receptor overlapping transcript-like 1

4

1

High-throughput

0.683

High

636245

MAL
Myelin and lymphocyte protein

4

0

High-throughput

0.668

High

1369295

SC22A
Vesicle-trafficking protein SEC22a

4

0

High-throughput

0.668

High

292021

CRTAP
Cartilage-associated protein

3

9

High-throughput

0.667

High

839911

AF9
Protein AF-9

3

1

High-throughput

0.667

High

1029435

IL9R
Interleukin-9 receptor

3

2

High-throughput

0.667

High

1181412

P3H1
Prolyl 3-hydroxylase 1

3

9

High-throughput

0.667

High

1192270

ZACN
Ligand-gated cation channel ZACN

3

5

High-throughput

0.667

High

1242887

S39A4
Zinc transporter ZIP4

3

2

High-throughput

0.667

High

1369321

CIZ1
Cip1-interacting zinc finger protein

3

2

High-throughput

0.667

High

1369302

LNP
Endoplasmic reticulum junction formation protein lunapark

4

0

High-throughput

0.661

High

1369305

PININ
Pinin

4

0

High-throughput

0.661

High

1369331

ALG5
Dolichyl-phosphate beta-glucosyltransferase

4

0

High-throughput

0.661

High

1369332

TX264
Testis-expressed protein 264

4

0

High-throughput

0.661

High

1369288

EDA
Ectodysplasin-A

1

17

Small-scale

0.647

High

883433

CY561
Transmembrane ascorbate-dependent reductase CYB561

3

0

High-throughput

0.646

High

1369323

DOLK
Dolichol kinase

3

0

High-throughput

0.646

High

230083

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

0

High-throughput

0.638

High

906911

GPM6A
Neuronal membrane glycoprotein M6-a

3

0

High-throughput

0.638

High

1191787

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

3

0

High-throughput

0.638

High

1369301

OSBL8
Oxysterol-binding protein-related protein 8

3

0

High-throughput

0.638

High

190158

TNC18
Trinucleotide repeat-containing gene 18 protein

4

2

High-throughput

0.630

High

604710

UBF1
Nucleolar transcription factor 1

4

3

High-throughput

0.630

High

1369307

CWC22
Pre-mRNA-splicing factor CWC22 homolog

4

1

High-throughput

0.630

High

469691

MMP2
72 kDa type IV collagenase

2

20

High-throughput

0.628

High

733712

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

4

High-throughput

0.628

High

771193

APJ
Apelin receptor

2

2

High-throughput

0.628

High

845527

PI2R
Prostacyclin receptor

2

1

High-throughput

0.628

High

1159092

C3AR
C3a anaphylatoxin chemotactic receptor

2

4

High-throughput

0.628

High

1369298

GPR21
Probable G-protein coupled receptor 21

2

2

High-throughput

0.628

High

1369316

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

4

High-throughput

0.628

High

1369330

PCDC2
Protocadherin alpha-C2

2

1

High-throughput

0.628

High

1360190

5HT3C
5-hydroxytryptamine receptor 3C

2

4

High-throughput

0.611

High

175917

SET1A
Histone-lysine N-methyltransferase SETD1A

3

1

High-throughput

0.609

High

922550

AP3M2
AP-3 complex subunit mu-2

3

1

High-throughput

0.609

High

1103495

AP3B2
AP-3 complex subunit beta-2

3

2

High-throughput

0.609

High

1249392

CWC27
Spliceosome-associated protein CWC27 homolog

3

1

High-throughput

0.609

High

1358812

KBTB7
Kelch repeat and BTB domain-containing protein 7

3

5

High-throughput

0.609

High

1369315

CXXC1
CXXC-type zinc finger protein 1

3

2

High-throughput

0.609

High

1369326

AP3M1
AP-3 complex subunit mu-1

3

1

High-throughput

0.609

High

932701

EMP1
Epithelial membrane protein 1

2

2

High-throughput

0.606

High

1030374

PMP22
Peripheral myelin protein 22

2

2

High-throughput

0.606

High

1369312

S38A7
Sodium-coupled neutral amino acid transporter 7

2

1

High-throughput

0.606

High

1369318

LPAR3
Lysophosphatidic acid receptor 3

2

1

High-throughput

0.606

High

1355914

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

2

0

High-throughput

0.602

High

692242

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

0

High-throughput

0.601

High

1212816

UBR4
E3 ubiquitin-protein ligase UBR4

2

0

High-throughput

0.585

High

941756

TM50B
Transmembrane protein 50B

2

0

High-throughput

0.580

High

1195540

CTXN3
Cortexin-3

2

0

High-throughput

0.580

High

1205525

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

0

High-throughput

0.580

High

1229441

TMM42
Transmembrane protein 42

2

0

High-throughput

0.580

High

1369304

TMM60
Transmembrane protein 60

2

0

High-throughput

0.580

High

1369308

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

0

High-throughput

0.576

High

1369311

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

1

High-throughput

0.573

High

1369322

EDAR
Tumor necrosis factor receptor superfamily member EDAR

2

0

Small-scale

0.559

High

1369319

AFF4
AF4/FMR2 family member 4

2

4

High-throughput

0.558

High

1369325

SRRM2
Serine/arginine repetitive matrix protein 2

2

1

High-throughput

0.558

High

1340401

RASF8
Ras association domain-containing protein 8

2

1

High-throughput

0.549

High

380465

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.536

High

539730

ACHB
Acetylcholine receptor subunit beta

1

5

High-throughput

0.536

High

567046

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

13

High-throughput

0.536

High

663527

FSHR
Follicle-stimulating hormone receptor

1

5

High-throughput

0.536

High

723250

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

4

High-throughput

0.536

High

761093

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

1

2

High-throughput

0.536

High

851195

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

3

High-throughput

0.536

High

946579

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.536

High

1057569

ACHD
Acetylcholine receptor subunit delta

1

5

High-throughput

0.536

High

1101612

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.536

High

1369299

CIB1
Calcium and integrin-binding protein 1

1

1

High-throughput

0.536

High

1369303

S39A8
Metal cation symporter ZIP8

1

2

High-throughput

0.536

High

1369329

PCDB1
Protocadherin beta-1

1

1

High-throughput

0.536

High

1232388

Q6FHL7
Leptin receptor overlapping transcript-like 1

1

1

High-throughput

0.515

High

1008046

KCJ10
ATP-sensitive inward rectifier potassium channel 10

1

0

High-throughput

0.513

High

1010509

EREP3
Protein ENTREP3

1

0

High-throughput

0.513

High

1333587

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1352082

TS1R2
Taste receptor type 1 member 2

1

0

High-throughput

0.513

High

1369292

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

1369293

TM169
Transmembrane protein 169

1

0

High-throughput

0.513

High

1369313

SC5A4
Probable glucose sensor protein SLC5A4

1

0

High-throughput

0.513

High

1205011

RABL3
Rab-like protein 3

1

1

High-throughput

0.489

High

334862

IPO7
Importin-7

1

1

High-throughput

0.479

High

807516

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.479

High

1369314

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.479

High

1349197

Q8TBU1
Oligosaccharyltransferase complex subunit

1

1

High-throughput

0.470

High

1369309

JPH1
Junctophilin-1

1

0

High-throughput

0.458

High

324023

CSTN1
Calsyntenin-1

1

3

High-throughput

0.445

High

1348292

GOGA5
Golgin subfamily A member 5

1

2

High-throughput

0.445

High

1369289

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.445

High

1369306

EVA1A
Protein eva-1 homolog A

1

1

High-throughput

0.445

High

1369317

B4GT7
Beta-1,4-galactosyltransferase 7

1

2

High-throughput

0.445

High

1369320

FEM1B
Protein fem-1 homolog B

1

3

High-throughput

0.445

High

106393

APRIO
Alternative prion protein

1

11

High-throughput

0.437

High

316545

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.426

High

726685

SDC4
Syndecan-4

1

0

High-throughput

0.426

High

755363

ABCD1
ATP-binding cassette sub-family D member 1

1

0

High-throughput

0.426

High

1004378

NOP14
Nucleolar protein 14

1

0

High-throughput

0.426

High

1159787

OCLN
Occludin

1

0

High-throughput

0.426

High

1236255

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1238662

TM214
Transmembrane protein 214

1

0

High-throughput

0.426

High

1293275

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.426

High

1324745

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.426

High

1369290

TRI44
Tripartite motif-containing protein 44

1

0

High-throughput

0.426

High

1369310

CHSTC
Carbohydrate sulfotransferase 12

1

0

High-throughput

0.426

High

1369328

TBL2
Transducin beta-like protein 2

1

0

High-throughput

0.426

High

346671

TTC4
Tetratricopeptide repeat protein 4

1

3

High-throughput

0.407

High

1369297

NP1L3
Nucleosome assembly protein 1-like 3

1

2

High-throughput

0.407

High

1369324

SET1B
Histone-lysine N-methyltransferase SETD1B

1

1

High-throughput

0.407

High

1369294

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

4

0

High-throughput

0.360

High

1369291

GIMA5
GTPase IMAP family member 5

3

0

High-throughput

0.352

High

884183

SRP09
Signal recognition particle 9 kDa protein

2

0

High-throughput

0.328

High

1288433

SO6A1
Solute carrier organic anion transporter family member 6A1

2

0

High-throughput

0.328

High

1145307

RNPS1
RNA-binding protein with serine-rich domain 1

2

0

High-throughput

0.298

High

1369296

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.249

Low

1369300

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

High-throughput

0.249

Low

1369327

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.249

Low

1186499

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.232

Low

1214971

RN187
E3 ubiquitin-protein ligase RNF187

1

0

High-throughput

0.232

Low

1287764

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

1308710

FOXP4
Forkhead box protein P4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025