Protein: ERF1
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)

Gene: ERF1, ETF1
Organism: Homo sapiens
Interactions: 125
UniProt ID: P62495

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002184 - cytoplasmic translational termination
GO:0003723 - RNA binding
GO:0003747 - translation release factor activity
GO:0004045 - peptidyl-tRNA hydrolase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

581491

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

8

8

Small-scale

0.968

High

976752

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

5

8

Small-scale

0.930

High

976740

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

2

High-throughput

0.789

High

976737

KEAP1
Kelch-like ECH-associated protein 1

6

0

High-throughput

0.708

High

959117

ABCE1
ATP-binding cassette sub-family E member 1

1

5

High-throughput

0.618

High

708942

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

976764

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

0

High-throughput

0.602

High

241310

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

436643

KPCB
Protein kinase C beta type

2

2

High-throughput

0.571

High

976768

SMG1
Serine/threonine-protein kinase SMG1

2

1

Small-scale

0.571

High

976773

RNF26
E3 ubiquitin-protein ligase RNF26

2

1

High-throughput

0.558

High

976729

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.557

High

175638

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.536

High

274527

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

856630

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.536

High

976756

GEMI5
Gem-associated protein 5

1

2

High-throughput

0.536

High

976759

RENT1
Regulator of nonsense transcripts 1

1

2

Small-scale

0.536

High

341925

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

390009

ALBU
Albumin

1

0

High-throughput

0.513

High

611821

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

976730

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.513

High

976739

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

976793

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

185583

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

507788

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

976731

HXC5
Homeobox protein Hox-C5

1

2

High-throughput

0.489

High

976762

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

2

High-throughput

0.489

High

126536

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.479

High

172664

XPO1
Exportin-1

1

3

High-throughput

0.479

High

363089

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

536908

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

550212

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

580974

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

606566

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

609980

VGFR1
Vascular endothelial growth factor receptor 1

1

3

High-throughput

0.479

High

731173

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

910000

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.479

High

940900

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

946093

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

955027

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

961927

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

962697

RND3
Rho-related GTP-binding protein RhoE

1

6

High-throughput

0.479

High

976728

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

976732

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.479

High

976734

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

976741

RHOH
Rho-related GTP-binding protein RhoH

1

4

High-throughput

0.479

High

976742

MLF2
Myeloid leukemia factor 2

1

1

High-throughput

0.479

High

976743

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.479

High

976747

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

976748

RHOU
Rho-related GTP-binding protein RhoU

1

6

High-throughput

0.479

High

976760

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

976772

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

4

High-throughput

0.479

High

976777

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

976778

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.479

High

976781

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.479

High

976786

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.479

High

976788

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

976789

FKBPL
FK506-binding protein-like

1

2

High-throughput

0.479

High

976790

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

976791

ARI1
E3 ubiquitin-protein ligase ARIH1

1

3

High-throughput

0.479

High

123367

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

336392

SVIL
Supervillin

1

0

High-throughput

0.458

High

408785

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

612962

EGR1
Early growth response protein 1

1

0

Small-scale

0.458

High

718795

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

974513

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

976733

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.458

High

976735

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

976738

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

976749

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

976751

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

976754

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

976761

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

976766

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

976770

NECD
Necdin

1

0

High-throughput

0.458

High

976780

ANLN
Anillin

1

0

High-throughput

0.458

High

976782

ZDH18
Palmitoyltransferase ZDHHC18

1

0

Small-scale

0.458

High

429663

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

529533

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

942534

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

976744

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

976769

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.445

High

976792

RBM8A
RNA-binding protein 8A

1

1

Small-scale

0.445

High

259741

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

318704

RHBT1
Rho-related BTB domain-containing protein 1

1

5

High-throughput

0.437

High

371672

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

650116

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

695143

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720177

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.437

High

787000

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.437

High

878905

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

976746

LMTK1
Serine/threonine-protein kinase LMTK1

1

3

High-throughput

0.437

High

976750

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

976753

ZDH23
Palmitoyltransferase ZDHHC23

1

1

Small-scale

0.437

High

976765

RHOV
Rho-related GTP-binding protein RhoV

1

6

High-throughput

0.437

High

976767

LMTK3
Serine/threonine-protein kinase LMTK3

1

5

High-throughput

0.437

High

976774

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

976776

RHOJ
Rho-related GTP-binding protein RhoJ

1

4

High-throughput

0.437

High

976736

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

876808

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.409

High

886720

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

416004

CP1A1
Cytochrome P450 1A1

3

0

High-throughput

0.347

High

387815

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

976757

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

976783

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.328

High

976785

MBD5
Methyl-CpG-binding domain protein 5

2

0

High-throughput

0.318

High

154662

ARI1A
AT-rich interactive domain-containing protein 1A

1

0

High-throughput

0.279

Low

484480

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

976775

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.269

Low

892659

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

353207

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

355182

ACL6A
Actin-like protein 6A

1

0

High-throughput

0.249

Low

588406

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

642779

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

767897

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

832688

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

976745

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

976755

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

976758

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

976763

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

976771

RNF5
E3 ubiquitin-protein ligase RNF5

1

0

High-throughput

0.249

Low

976779

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

976784

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

976787

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.249

Low

619693

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025