Protein: SMG8
Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)

Gene: SMG8
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q8ND04

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0005829 - cytosol
GO:0045859 - regulation of protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1336159

SMG1
Serine/threonine-protein kinase SMG1

2

0

Small-scale

0.801

High

1336172

SMG9
Nonsense-mediated mRNA decay factor SMG9

3

1

Small-scale

0.675

High

712242

TKT
Transketolase

2

0

High-throughput

0.602

High

1093007

CDC16
Cell division cycle protein 16 homolog

2

0

High-throughput

0.602

High

1311494

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.602

High

1336155

AZIN2
Antizyme inhibitor 2

2

0

High-throughput

0.602

High

1336161

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.602

High

1336174

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

1336187

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

1336191

RBM8A
RNA-binding protein 8A

2

0

Small-scale

0.585

High

366254

FA9
Coagulation factor IX

2

1

High-throughput

0.574

High

1308089

LRC49
Leucine-rich repeat-containing protein 49

2

1

High-throughput

0.574

High

1310604

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

1

High-throughput

0.533

High

158472

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

191369

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

296805

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

334215

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

347181

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

457563

TBB5
Tubulin beta chain

1

0

High-throughput

0.513

High

549642

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

606017

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

1064585

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.513

High

1144081

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1218053

CBPC6
Cytosolic carboxypeptidase 6

1

0

High-throughput

0.513

High

1334205

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.513

High

1336151

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

1336154

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.513

High

1336156

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1336165

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1336166

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1336168

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

1336179

SPHK1
Sphingosine kinase 1

1

0

High-throughput

0.513

High

1336181

KLH14
Kelch-like protein 14

1

0

High-throughput

0.513

High

1336171

DRC3
Dynein regulatory complex subunit 3

1

1

High-throughput

0.489

High

1280693

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.479

High

1336189

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

213477

CTIF
CBP80/20-dependent translation initiation factor

1

0

High-throughput

0.458

High

1056857

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.458

High

1106003

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

1106619

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1107935

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1252336

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1336150

LS14A
Protein LSM14 homolog A

1

0

High-throughput

0.458

High

1336175

ANLN
Anillin

1

0

High-throughput

0.458

High

1336183

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1336185

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

1336186

RUVB1
RuvB-like 1

1

0

Small-scale

0.458

High

1239249

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

262268

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.407

High

888471

TSP3
Thrombospondin-3

3

0

High-throughput

0.347

High

640227

EPHA1
Ephrin type-A receptor 1

3

0

High-throughput

0.345

High

1336164

NICN1
Nicolin-1

3

0

High-throughput

0.345

High

1233765

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.328

High

1248564

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1256397

TPGS1
Tubulin polyglutamylase complex subunit 1

2

0

High-throughput

0.328

High

1333034

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.328

High

1336176

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

0

High-throughput

0.328

High

1010075

DLK1
Protein delta homolog 1

2

0

High-throughput

0.318

High

1336163

CAB45
45 kDa calcium-binding protein

2

0

High-throughput

0.318

High

1336153

CA054
Uncharacterized protein C1orf54

2

0

High-throughput

0.313

High

1336192

NPTN
Neuroplastin

2

0

High-throughput

0.313

High

1202100

HS904
Putative heat shock protein HSP 90-alpha A4

2

0

High-throughput

0.288

High

181644

CETN3
Centrin-3

1

0

High-throughput

0.279

Low

190438

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

261525

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

317348

ACL6B
Actin-like protein 6B

1

0

High-throughput

0.279

Low

472193

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

690045

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

848682

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

1006273

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.279

Low

1041776

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.279

Low

1081272

LR74A
Leucine-rich repeat-containing protein 74A

1

0

High-throughput

0.279

Low

1101388

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1147964

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1177032

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1286609

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.279

Low

1325806

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1336152

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1336157

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1336158

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1336160

CIB3
Calcium and integrin-binding family member 3

1

0

High-throughput

0.279

Low

1336162

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1336169

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

1336182

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1336190

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

294041

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

372603

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

412272

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

635274

EFNA1
Ephrin-A1

1

0

High-throughput

0.249

Low

695969

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

766703

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

1034778

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.249

Low

1200048

EIPR1
EARP and GARP complex-interacting protein 1

1

0

High-throughput

0.249

Low

1254693

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1290237

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

0

High-throughput

0.249

Low

1329749

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.249

Low

1336149

RN214
RING finger protein 214

1

0

High-throughput

0.249

Low

1336167

UNK
RING finger protein unkempt homolog

1

0

High-throughput

0.249

Low

1336170

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

0

High-throughput

0.249

Low

1336173

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1336177

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

1336184

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1336188

T22D4
TSC22 domain family protein 4

1

0

High-throughput

0.249

Low

50624

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

239138

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low

437738

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

683287

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

754069

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

1219517

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1253632

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

1293868

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

1330714

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.232

Low

1336178

TRM1
tRNA

1

0

High-throughput

0.232

Low

1336180

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025